التفاصيل البيبلوغرافية
| العنوان: |
Differences in exposure to toxic and/or carcinogenic volatile organic compounds between Black and White cigarette smokers |
| المؤلفون: |
St.Helen, Gideon, Benowitz, Neal L, Ko, Jennifer, Jacob, Peyton, Gregorich, Steven E, Pérez-Stable, Eliseo J, Murphy, Sharon E, Hecht, Stephen S, Hatsukami, Dorothy K, Donny, Eric C |
| المصدر: |
Journal of Exposure Science & Environmental Epidemiology, vol 31, iss 2 |
| بيانات النشر: |
eScholarship, University of California |
| سنة النشر: |
2021 |
| المجموعة: |
University of California: eScholarship |
| مصطلحات موضوعية: |
Public Health, Health Sciences, Prevention, Tobacco, Tobacco Smoke and Health, Cancer, Good Health and Well Being, Adult, Biomarkers, Carcinogens, Cotinine, Humans, Nitrosamines, Smokers, Tobacco Products, United States, Volatile Organic Compounds, Racial differences, tobacco-related disparities, acrolein, Chemical Sciences, Environmental Sciences, Medical and Health Sciences, Epidemiology |
| جغرافية الموضوع: |
211 - 223 |
| الوصف: |
ObjectiveIt is unclear why Black smokers in the United States have elevated risk of some tobacco-related diseases compared to White smokers. One possible causal mechanism is differential intake of tobacco toxicants, but results across studies are inconsistent. Thus, we examined racial differences in biomarkers of toxic volatile organic compounds (VOCs) present in tobacco smoke.MethodWe analyzed baseline data collected from 182 Black and 184 White adult smokers who participated in a randomized clinical trial in 2013-2014 at 10 sites across the United States. We examined differences in urinary levels of ten VOC metabolites, total nicotine equivalents (TNE), and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), controlling for covariates such as cigarettes per day (CPD), as well as differences in VOCs per TNE to assess the extent to which tobacco exposure, and not metabolic factors, accounted for racial differences.ResultsConcentration of metabolites of acrolein, acrylonitrile, ethylene oxide, and methylating agents were significantly higher in Blacks compared to Whites when controlled for covariates. Other than the metabolite of methylating agents, VOCs per TNE did not differ between Blacks and Whites. Concentrations of TNE/CPD and VOCs/CPD were significantly higher in Blacks. Menthol did not contribute to racial differences in VOC levels.ConclusionsFor a given level of CPD, Black smokers likely take in higher levels of acrolein, acrylonitrile, and ethylene oxide than White smokers. Our findings are consistent with Blacks taking in more nicotine and toxicants per cigarette smoked, which may explain their elevated disease risk relative to other racial groups. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
qt5mg5j52h; https://escholarship.org/uc/item/5mg5j52hTest |
| الإتاحة: |
https://escholarship.org/uc/item/5mg5j52hTest |
| حقوق: |
public |
| رقم الانضمام: |
edsbas.A1A893CC |
| قاعدة البيانات: |
BASE |
