التفاصيل البيبلوغرافية
| العنوان: |
Genetic pleiotropy between multiple sclerosis and schizophrenia but not bipolar disorder: differential involvement of immune-related gene loci |
| المؤلفون: |
Andreassen, OA, Harbo, HF, Wang, Y, Thompson, WK, Schork, AJ, Mattingsdal, M, Zuber, V, Bettella, F, Ripke, S, Kelsoe, JR, Kendler, KS, O'Donovan, MC, Sklar, P, McEvoy, LK, Desikan, RS, Lie, BA, Djurovic, S, Dale, AM |
| المصدر: |
Molecular Psychiatry, vol 20, iss 2 |
| بيانات النشر: |
eScholarship, University of California |
| سنة النشر: |
2015 |
| المجموعة: |
University of California: eScholarship |
| مصطلحات موضوعية: |
Clinical Research, Neurosciences, Multiple Sclerosis, Prevention, Autoimmune Disease, Genetics, Schizophrenia, Bipolar Disorder, Brain Disorders, Human Genome, Mental Health, Serious Mental Illness, Neurodegenerative, Aetiology, 2.1 Biological and endogenous factors, Inflammatory and immune system, Female, Follow-Up Studies, Genetic Pleiotropy, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, HLA Antigens, Humans, Male, Polymorphism, Single Nucleotide, false discovery rate, HLA region, polygenic pleiotropy |
| جغرافية الموضوع: |
207 - 214 |
| الوصف: |
Converging evidence implicates immune abnormalities in schizophrenia (SCZ), and recent genome-wide association studies (GWAS) have identified immune-related single-nucleotide polymorphisms (SNPs) associated with SCZ. Using the conditional false discovery rate (FDR) approach, we evaluated pleiotropy in SNPs associated with SCZ (n=21,856) and multiple sclerosis (MS) (n=43,879), an inflammatory, demyelinating disease of the central nervous system. Because SCZ and bipolar disorder (BD) show substantial clinical and genetic overlap, we also investigated pleiotropy between BD (n=16,731) and MS. We found significant genetic overlap between SCZ and MS and identified 21 independent loci associated with SCZ, conditioned on association with MS. This enrichment was driven by the major histocompatibility complex (MHC). Importantly, we detected the involvement of the same human leukocyte antigen (HLA) alleles in both SCZ and MS, but with an opposite directionality of effect of associated HLA alleles (that is, MS risk alleles were associated with decreased SCZ risk). In contrast, we found no genetic overlap between BD and MS. Considered together, our findings demonstrate genetic pleiotropy between SCZ and MS and suggest that the MHC signals may differentiate SCZ from BD susceptibility. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
qt39p9n9q8; https://escholarship.org/uc/item/39p9n9q8Test |
| الإتاحة: |
https://escholarship.org/uc/item/39p9n9q8Test |
| حقوق: |
public |
| رقم الانضمام: |
edsbas.5D39ABCC |
| قاعدة البيانات: |
BASE |
