التفاصيل البيبلوغرافية
| العنوان: |
Targeting tumor suppressor networks for cancer therapeutics. |
| المؤلفون: |
Guo, Xuning Emily, Ngo, Bryan, Modrek, Aram Sandaldjian, Lee, Wen-Hwa |
| المصدر: |
Current Drug Targets, vol 15, iss 1 |
| بيانات النشر: |
eScholarship, University of California |
| سنة النشر: |
2014 |
| المجموعة: |
University of California: eScholarship |
| مصطلحات موضوعية: |
Genetics, Cancer, Rare Diseases, Orphan Drug, Breast Cancer, Development of treatments and therapeutic interventions, Aetiology, 2.1 Biological and endogenous factors, 5.1 Pharmaceuticals, Genes, Tumor Suppressor, Genetic Therapy, Humans, Neoplasms, Pharmacology and Pharmaceutical Sciences, Pharmacology & Pharmacy |
| جغرافية الموضوع: |
2 - 16 |
| الوصف: |
Cancer is a consequence of mutations in genes that control cell proliferation, differentiation and cellular homeostasis. These genes are classified into two categories: oncogenes and tumor suppressor genes. Together, overexpression of oncogenes and loss of tumor suppressors are the dominant driving forces for tumorigenesis. Hence, targeting oncogenes and tumor suppressors hold tremendous therapeutic potential for cancer treatment. In the last decade, the predominant cancer drug discovery strategy has relied on a traditional reductionist approach of dissecting molecular signaling pathways and designing inhibitors for the selected oncogenic targets. Remarkable therapies have been developed using this approach; however, targeting oncogenes is only part of the picture. Our understanding of the importance of tumor suppressors in preventing tumorigenesis has also advanced significantly and provides a new therapeutic window of opportunity. Given that tumor suppressors are frequently mutated, deleted, or silenced with loss-of-function, restoring their normal functions to treat cancer holds tremendous therapeutic potential. With the rapid expansion in our knowledge of cancer over the last several decades, developing effective anticancer regimens against tumor suppressor pathways has never been more promising. In this article, we will review the concept of tumor suppression, and outline the major therapeutic strategies and challenges of targeting tumor suppressor networks for cancer therapeutics. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
qt7z93x992; https://escholarship.org/uc/item/7z93x992Test |
| الإتاحة: |
https://escholarship.org/uc/item/7z93x992Test |
| حقوق: |
public |
| رقم الانضمام: |
edsbas.6370AD87 |
| قاعدة البيانات: |
BASE |
