التفاصيل البيبلوغرافية
| العنوان: |
Association of urinary KIM-1, L-FABP, NAG and NGAL with incident end-stage renal disease and mortality in American Indians with type 2 diabetes mellitus |
| المؤلفون: |
Fufaa, Gudeta D, Weil, E Jennifer, Nelson, Robert G, Hanson, Robert L, Bonventre, Joseph V, Sabbisetti, Venkata, Waikar, Sushrut S, Mifflin, Theodore E, Zhang, Xiaoming, Xie, Dawei, Hsu, Chi-yuan, Feldman, Harold I, Coresh, Josef, Vasan, Ramachandran S, Kimmel, Paul L, Liu, Kathleen D, for the Chronic Kidney Disease Biomarkers Consortium Investigators |
| المصدر: |
Diabetologia, vol 58, iss 1 |
| بيانات النشر: |
eScholarship, University of California |
| سنة النشر: |
2015 |
| المجموعة: |
University of California: eScholarship |
| مصطلحات موضوعية: |
Epidemiology, Biomedical and Clinical Sciences, Health Sciences, Kidney Disease, Renal and urogenital, Good Health and Well Being, Acute-Phase Proteins, Adolescent, Adult, Aged, Diabetes Mellitus, Type 2, Diabetic Nephropathies, Fatty Acid-Binding Proteins, Female, Hepatitis A Virus Cellular Receptor 1, Humans, Incidence, Indians, North American, Kidney Failure, Chronic, Lipocalin-2, Lipocalins, Male, Membrane Glycoproteins, Middle Aged, Neoplasm Proteins, Proto-Oncogene Proteins, Receptors |
| جغرافية الموضوع: |
188 - 198 |
| الوصف: |
Aims/hypothesisKidney injury molecule 1 (KIM-1), liver fatty acid-binding protein (L-FABP), N-acetyl-β-D-glucosaminidase (NAG) and neutrophil gelatinase-associated lipocalin (NGAL) are urinary biomarkers of renal tubular injury. We examined their association with incident end-stage renal disease (ESRD) and all-cause mortality in American Indians with type 2 diabetes.MethodsBiomarker concentrations were measured in baseline urine samples in 260 Pima Indians who were followed for a median of 14 years. HRs were reported per SD of creatinine (Cr)-normalised log-transformed KIM-1, NAG and NGAL, and for three categories of L-FABP.ResultsDuring follow-up, 74 participants developed ESRD and 101 died. Median concentrations of KIM-1/Cr, NAG/Cr and NGAL/Cr and the proportion of detectable L-FABP were highest in those with macroalbuminuria (p < 0.001 for KIM-1/Cr, NAG/Cr and L-FABP; p = 0.006 for NGAL/Cr). After multivariable adjustment, NGAL/Cr was positively associated with ESRD (HR 1.59, 95% CI 1.20, 2.11) and mortality (HR 1.39, 95% CI 1.06, 1.82); L-FABP/Cr was inversely associated with ESRD (HR [for highest vs lowest tertile] 0.40, 95% CI 0.19, 0.83). Addition of NGAL/Cr to models that included albuminuria and glomerular filtration rate increased the c-statistic for predicting ESRD from 0.828 to 0.833 (p = 0.001) and for death from 0.710 to 0.722 (p = 0.018). Addition of L-FABP/Cr increased the c-statistic for ESRD from 0.828 to 0.832 (p = 0.042).Conclusions/interpretationIn Pima Indians with type 2 diabetes, urinary concentrations of NGAL and L-FABP are associated with important health outcomes, but they are unlikely to add to risk prediction with standard markers in a clinically meaningful way given the small increase in the c-statistic. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
qt0b9258h3; https://escholarship.org/uc/item/0b9258h3Test |
| الإتاحة: |
https://escholarship.org/uc/item/0b9258h3Test |
| حقوق: |
public |
| رقم الانضمام: |
edsbas.BCFFE9D3 |
| قاعدة البيانات: |
BASE |
