دورية أكاديمية
An integrative systems genetic analysis of mammalian lipid metabolism.
| العنوان: | An integrative systems genetic analysis of mammalian lipid metabolism. |
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| المؤلفون: | Parker, Benjamin L, Calkin, Anna C, Seldin, Marcus M, Keating, Michael F, Tarling, Elizabeth J, Yang, Pengyi, Moody, Sarah C, Liu, Yingying, Zerenturk, Eser J, Needham, Elise J, Miller, Matthew L, Clifford, Bethan L, Morand, Pauline, Watt, Matthew J, Meex, Ruth CR, Peng, Kang-Yu, Lee, Richard, Jayawardana, Kaushala, Pan, Calvin, Mellett, Natalie A, Weir, Jacquelyn M, Lazarus, Ross, Lusis, Aldons J, Meikle, Peter J, James, David E, de Aguiar Vallim, Thomas Q, Drew, Brian G |
| المصدر: | Nature, vol 567, iss 7747 |
| بيانات النشر: | eScholarship, University of California |
| سنة النشر: | 2019 |
| المجموعة: | University of California: eScholarship |
| مصطلحات موضوعية: | Liver, Animals, Mice, Inbred C57BL, Inbred DBA, Humans, Obesity, Proteasome Endopeptidase Complex, Lipids, Proteomics, Male, Lipid Metabolism, HEK293 Cells, Genetics, Liver Disease, Digestive Diseases, Biotechnology, 2.1 Biological and endogenous factors, Aetiology, General Science & Technology |
| جغرافية الموضوع: | 187 - 193 |
| الوصف: | Dysregulation of lipid homeostasis is a precipitating event in the pathogenesis and progression of hepatosteatosis and metabolic syndrome. These conditions are highly prevalent in developed societies and currently have limited options for diagnostic and therapeutic intervention. Here, using a proteomic and lipidomic-wide systems genetic approach, we interrogated lipid regulatory networks in 107 genetically distinct mouse strains to reveal key insights into the control and network structure of mammalian lipid metabolism. These include the identification of plasma lipid signatures that predict pathological lipid abundance in the liver of mice and humans, defining subcellular localization and functionality of lipid-related proteins, and revealing functional protein and genetic variants that are predicted to modulate lipid abundance. Trans-omic analyses using these datasets facilitated the identification and validation of PSMD9as a previously unknown lipid regulatory protein. Collectively, our study serves as a rich resource for probing mammalian lipid metabolism and provides opportunities for the discovery of therapeutic agents and biomarkers in the setting of hepatic lipotoxicity. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| العلاقة: | qt5090j5bq; https://escholarship.org/uc/item/5090j5bqTest; https://escholarship.org/content/qt5090j5bq/qt5090j5bq.pdfTest |
| DOI: | 10.1038/s41586-019-0984-y |
| الإتاحة: | https://doi.org/10.1038/s41586-019-0984-yTest https://escholarship.org/uc/item/5090j5bqTest https://escholarship.org/content/qt5090j5bq/qt5090j5bq.pdfTest |
| حقوق: | public |
| رقم الانضمام: | edsbas.C31E08D8 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41586-019-0984-y |
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