التفاصيل البيبلوغرافية
| العنوان: |
Acceleration of ALA‐induced PpIX fluorescence development in the oral mucosa |
| المؤلفون: |
Charoenbanpachon, Sirintra, Krasieva, Tatiana, Ebihara, Arata, Osann, Kathryn, Wilder‐Smith, Petra |
| المصدر: |
Lasers in Surgery and Medicine, vol 32, iss 3 |
| بيانات النشر: |
eScholarship, University of California |
| سنة النشر: |
2003 |
| المجموعة: |
University of California: eScholarship |
| مصطلحات موضوعية: |
Biomedical and Clinical Sciences, Dentistry, Administration, Topical, Aminolevulinic Acid, Analysis of Variance, Animals, Carcinoma, Squamous Cell, Cricetinae, Disease Models, Animal, Mouth Mucosa, Mouth Neoplasms, Photosensitizing Agents, Probability, Protoporphyrins, Sensitivity and Specificity, Spectrometry, Fluorescence, Clinical Sciences, Dermatology & Venereal Diseases |
| جغرافية الموضوع: |
185 - 188 |
| الوصف: |
Background and objectivesThe development of 5-aminolevulinic acid (ALA)-induced tissue fluorescence is optimal 2-4 hours after ALA application. Goal of this work was to develop a means of accelerating oral topical ALA-induced tissue fluorescence.Study design/materials and methodsIn 300 hamsters, DMBA (9,10 dimethyl-1,2-benzanthracene) cheek pouch carcinogenesis produced dysplasia in 3-5 weeks. Topical application of 20% ALA in Eucerin was followed by localized ultrasound treatment (1, 3.3 MHz) in 150 animals. In 75 animals, ALA was applied in an Oral Pluronic Lecithin Organogel (OPLO-an absorption enhancer) vehicle. Seventy-five animals received only topical ALA in Eucerin. Hamsters were sacrificed and cryosections underwent fluorescence measurements, histological evaluation, 20-180 minutes after ALA application. One-way ANOVA detected independent effects of pathology on laser-induced fluorescence (LIF). Two-way ANOVA tested for independent effect of pathology and of OPLO, ultrasound, and interaction effects.ResultsUltrasound significantly (P < 0.05) accelerated tissue fluorescence development.ConclusionsLow-frequency ultrasound can accelerate ALA-induced fluorescence development. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
qt1j56n89v; https://escholarship.org/uc/item/1j56n89vTest |
| الإتاحة: |
https://escholarship.org/uc/item/1j56n89vTest |
| حقوق: |
CC-BY |
| رقم الانضمام: |
edsbas.78E29038 |
| قاعدة البيانات: |
BASE |
