التفاصيل البيبلوغرافية
| العنوان: |
Systemic Staphylococcus aureus infection mediated by Candida albicans hyphal invasion of mucosal tissue |
| المؤلفون: |
Schlecht, Lisa Marie, Peters, Brian M, Krom, Bastiaan P, Freiberg, Jeffrey A, Hänsch, Gertrud M, Filler, Scott G, Jabra-Rizk, Mary Ann, Shirtliff, Mark E |
| المصدر: |
Microbiology, vol 161, iss 1 |
| بيانات النشر: |
eScholarship, University of California |
| سنة النشر: |
2015 |
| المجموعة: |
University of California: eScholarship |
| مصطلحات موضوعية: |
Emerging Infectious Diseases, Infectious Diseases, 2.1 Biological and endogenous factors, Aetiology, 2.2 Factors relating to the physical environment, Infection, Animals, Bacterial Adhesion, Biofilms, Candida albicans, Disease Models, Animal, Humans, Hyphae, Mice, Microscopy, Confocal, Mouth Mucosa, Mucous Membrane, Staphylococcal Infections, Staphylococcus aureus, Time-Lapse Imaging, Microbiology |
| جغرافية الموضوع: |
168 - 181 |
| الوصف: |
Candida albicans and Staphylococcus aureus are often co-isolated in cases of biofilm-associated infections. C. albicans can cause systemic disease through morphological switch from the rounded yeast to the invasive hyphal form. Alternatively, systemic S. aureus infections arise from seeding through breaks in host epithelial layers although many patients have no documented portal of entry. We describe a novel strategy by which S. aureus is able to invade host tissue and disseminate via adherence to the invasive hyphal elements of Candida albicans. In vitro and ex vivo findings demonstrate a specific binding of the staphylococci to the candida hyphal elements. The C. albicans cell wall adhesin Als3p binds to multiple staphylococcal adhesins. Furthermore, Als3p is required for C. albicans to transport S. aureus into the tissue and cause a disseminated infection in an oral co-colonization model. These findings suggest that C. albicans can facilitate the invasion of S. aureus across mucosal barriers, leading to systemic infection in co-colonized patients. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| العلاقة: |
qt51t8m9jz; https://escholarship.org/uc/item/51t8m9jzTest |
| الإتاحة: |
https://escholarship.org/uc/item/51t8m9jzTest |
| حقوق: |
public |
| رقم الانضمام: |
edsbas.2D19C342 |
| قاعدة البيانات: |
BASE |
