دورية أكاديمية

NADPH Oxidase-2: Linking Glucose, Acidosis, and Excitotoxicity in Stroke

التفاصيل البيبلوغرافية
العنوان: NADPH Oxidase-2: Linking Glucose, Acidosis, and Excitotoxicity in Stroke
المؤلفون: Brennan-Minnella, Angela M, Won, Seok Joon, Swanson, Raymond A
المصدر: Antioxidants and Redox Signaling, vol 22, iss 2
بيانات النشر: eScholarship, University of California
سنة النشر: 2015
المجموعة: University of California: eScholarship
مصطلحات موضوعية: Neurosciences, Brain Disorders, Stroke, Neurological, Acidosis, Glucose, Humans, Membrane Glycoproteins, NADPH Oxidase 2, NADPH Oxidases, Receptors, N-Methyl-D-Aspartate, Biochemistry and Cell Biology, Medical Biochemistry and Metabolomics, Pharmacology and Pharmaceutical Sciences, Biochemistry & Molecular Biology
جغرافية الموضوع: 161 - 174
الوصف: SignificanceNeuronal superoxide production contributes to cell death in both glutamate excitotoxicity and brain ischemia (stroke). NADPH oxidase-2 (NOX2) is the major source of neuronal superoxide production in these settings, and regulation of NOX2 activity can thereby influence outcome in stroke.Recent advancesReduced NOX2 activity can rescue cells from oxidative stress and cell death that otherwise occur in excitotoxicity and ischemia. NOX2 activity is regulated by several factors previously shown to affect outcome in stroke, including glucose availability, intracellular pH, protein kinase ζ/δ, casein kinase 2, phosphoinositide-3-kinase, Rac1/2, and phospholipase A2. The newly identified functions of these factors as regulators of NOX2 activity suggest alternative mechanisms for their effects on ischemic brain injury.Critical issuesKey aspects of these regulatory influences remain unresolved, including the mechanisms by which rac1 and phospholipase activities are coupled to N-methyl-D-aspartate (NMDA) receptors, and whether superoxide production by NOX2 triggers subsequent superoxide production by mitochondria.Future directionsIt will be important to establish whether interventions targeting the signaling pathways linking NMDA receptors to NOX2 in brain ischemia can provide a greater neuroprotective efficacy or a longer time window to treatment than provided by NMDA receptor blockade alone. It will likewise be important to determine whether dissociating superoxide production from the other signaling events initiated by NMDA receptors can mitigate the deleterious effects of NMDA receptor blockade.
نوع الوثيقة: article in journal/newspaper
وصف الملف: application/pdf
اللغة: unknown
العلاقة: qt2t49p81n; https://escholarship.org/uc/item/2t49p81nTest
الإتاحة: https://escholarship.org/uc/item/2t49p81nTest
حقوق: public
رقم الانضمام: edsbas.E3F306CE
قاعدة البيانات: BASE