التفاصيل البيبلوغرافية
| العنوان: |
Periarticular bone predicts knee osteoarthritis progression: Data from the Osteoarthritis Initiative |
| المؤلفون: |
Lo, Grace H, Schneider, Erika, Driban, Jeffrey B, Price, Lori Lyn, Hunter, David J, Eaton, Charles B, Hochberg, Marc C, Jackson, Rebecca D, Kwoh, C Kent, Nevitt, Michael C, Lynch, John A, McAlindon, Timothy E, Group, For The OAI Investigators |
| المصدر: |
Seminars in Arthritis and Rheumatism, vol 48, iss 2 |
| بيانات النشر: |
eScholarship, University of California |
| سنة النشر: |
2018 |
| المجموعة: |
University of California: eScholarship |
| مصطلحات موضوعية: |
Biomedical and Clinical Sciences, Clinical Sciences, Biomedical Imaging, Arthritis, Osteoarthritis, Aging, Prevention, Musculoskeletal, Absorptiometry, Photon, Aged, Bone Density, Disease Progression, Female, Femur, Humans, Knee Joint, Longitudinal Studies, Magnetic Resonance Imaging, Male, Middle Aged, Knee, Tibia, X-Rays, DXA, Morphometry, OAI Investigators Group, Public Health and Health Services, Arthritis & Rheumatology |
| جغرافية الموضوع: |
155 - 161 |
| الوصف: |
OBJECTIVE:Osteoarthritis (OA) is a disease with a substantial public health burden. Quantitative assessments of periarticular bone may be a biomarker capable of monitoring early disease progression. The purpose of this study was to evaluate whether measures of periarticular bone associate with longitudinal structural progression. METHODS:We conducted a 12-18 months longitudinal study using the Osteoarthritis Initiative (OAI). Participants received knee dual-energy x-ray absorptiometry (DXA), trabecular magnetic resonance (MR) imaging, and x-rays. Knee DXAs generated proximal tibial medial:lateral periarticular bone mineral density (paBMD) measures. Proximal tibial trabecular MR images were assessed for trabecular morphometry: apparent bone volume fraction (BVF), trabecular number, thickness, and spacing. Weight-bearing x-rays were assessed for medial tibiofemoral joint space narrowing (JSN). Chi-squared analyses assessed whether periarticular bone measures were predictive of worsening medial tibiofemoral JSN, adjusted for age, sex, and BMI. RESULTS:In all, 444 participants, mean age 64.2 ± 9.2 years, BMI 29.5 ± 4.6kg/m2, and 52% male at baseline. Medial JSN (radiographic progression) occurred in 40 participants (9%). Higher baseline medial:lateral paBMD, apparent BVF, trabecular number and thickness, and lower baseline and decreased trabecular spacing were all associated with more progression of JSN in the medial compartment. From lowest to highest baseline medial:lateral paBMD quartile groups, 2%, 5%, 11%, and 18% had medial JSN progression, respectively, between the 36- and 48-month visits, p-values = 0.001 and 0.002 unadjusted and adjusted. The rate of change in medial:lateral paBMD, apparent BVF, and spacing were associated with more medial JSN. For rate of medial:lateral paBMD change from lowest to highest quartile, the proportion of each group that experienced medial JSN progression were 5%, 5%, 11%, and 18%, with an unadjusted and adjusted p-value of 0.005. CONCLUSION:Baseline and most rates of ... |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
qt0sw8n2jm; https://escholarship.org/uc/item/0sw8n2jmTest |
| الإتاحة: |
https://escholarship.org/uc/item/0sw8n2jmTest |
| حقوق: |
public |
| رقم الانضمام: |
edsbas.ADCA1E10 |
| قاعدة البيانات: |
BASE |
