التفاصيل البيبلوغرافية
| العنوان: |
Gene expression and cell identity controlled by anaphase-promoting complex |
| المؤلفون: |
Oh, Eugene, Mark, Kevin G, Mocciaro, Annamaria, Watson, Edmond R, Prabu, J Rajan, Cha, Denny D, Kampmann, Martin, Gamarra, Nathan, Zhou, Coral Y, Rape, Michael |
| المصدر: |
Nature, vol 579, iss 7797 |
| بيانات النشر: |
eScholarship, University of California |
| سنة النشر: |
2020 |
| المجموعة: |
University of California: eScholarship |
| مصطلحات موضوعية: |
Biochemistry and Cell Biology, Bioinformatics and Computational Biology, Biological Sciences, Stem Cell Research, Genetics, Stem Cell Research - Nonembryonic - Non-Human, Underpinning research, 1.1 Normal biological development and functioning, Generic health relevance, Anaphase, Anaphase-Promoting Complex-Cyclosome, Cell Differentiation, Cell Division, Gene Expression Regulation, HEK293 Cells, HeLa Cells, Histones, Human Embryonic Stem Cells, Humans, Interphase, Intracellular Signaling Peptides and Proteins, Mitosis, Multiprotein Complexes, Organophosphates, Polyubiquitin, Proteasome Endopeptidase Complex, Transcription Initiation Site, Ubiquitin, Ubiquitination, General Science & Technology |
| جغرافية الموضوع: |
136 - 140 |
| الوصف: |
Metazoan development requires the robust proliferation of progenitor cells, the identities of which are established by tightly controlled transcriptional networks1. As gene expression is globally inhibited during mitosis, the transcriptional programs that define cell identity must be restarted in each cell cycle2-5 but how this is accomplished is poorly understood. Here we identify a ubiquitin-dependent mechanism that integrates gene expression with cell division to preserve cell identity. We found that WDR5 and TBP, which bind active interphase promoters6,7, recruit the anaphase-promoting complex (APC/C) to specific transcription start sites during mitosis. This allows APC/C to decorate histones withubiquitin chains branched at Lys11 and Lys48 (K11/K48-branched ubiquitin chains) that recruit p97 (also known as VCP) and the proteasome, which ensures the rapid expression of pluripotency genes in the next cell cycle. Mitotic exit and the re-initiation of transcription are thus controlled by a single regulator (APC/C), which provides a robust mechanism for maintaining cell identity throughout cell division. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
qt3tp7b0xg; https://escholarship.org/uc/item/3tp7b0xgTest |
| الإتاحة: |
https://escholarship.org/uc/item/3tp7b0xgTest |
| حقوق: |
public |
| رقم الانضمام: |
edsbas.A8C4720F |
| قاعدة البيانات: |
BASE |
