التفاصيل البيبلوغرافية
| العنوان: |
Comparison of Patient-reported Outcomes After External Beam Radiation Therapy and Combined External Beam With Low-dose-rate Brachytherapy Boost in Men With Localized Prostate Cancer |
| المؤلفون: |
Lee, Daniel J, Barocas, Daniel A, Zhao, Zhiguo, Huang, Li-Ching, Resnick, Matthew J, Koyoma, Tatsuki, Conwill, Ralph, McCollum, Dan, Cooperberg, Matthew R, Goodman, Michael, Greenfield, Sheldon, Hamilton, Ann S, Hashibe, Mia, Kaplan, Sherrie H, Paddock, Lisa E, Stroup, Antoinette M, Wu, Xiao-Cheng, Penson, David F, Hoffman, Karen E |
| المصدر: |
International Journal of Radiation Oncology • Biology • Physics, vol 102, iss 1 |
| بيانات النشر: |
eScholarship, University of California |
| سنة النشر: |
2018 |
| المجموعة: |
University of California: eScholarship |
| مصطلحات موضوعية: |
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Cancer, Urologic Diseases, Comparative Effectiveness Research, Aging, Prostate Cancer, Clinical Research, 7.1 Individual care needs, Management of diseases and conditions, Aged, Brachytherapy, Hormones, Humans, Intestines, Male, Middle Aged, Patient Reported Outcome Measures, Prostatic Neoplasms, Radiation Dosage, Radiotherapy Dosage, Sexual Dysfunction, Physiological, Survival Analysis, Urinary Incontinence, Other Physical Sciences, Oncology & Carcinogenesis, Theoretical and computational chemistry, Medical and biological physics |
| جغرافية الموضوع: |
116 - 126 |
| الوصف: |
PurposeTo compare patient-reported disease-specific functional outcomes after external beam radiation therapy (EBRT) and EBRT combined with low-dose-rate brachytherapy prostate boost (EB-LDR) among men with localized prostate cancer.Methods and materialsThe prospective, population-based Comparative Effectiveness Analysis of Surgery and Radiation study enrolled men with localized prostate cancer in 2011 to 2012. The 26-item Expanded Prostate Cancer Index Composite measured patient-reported disease-specific function at baseline and at 6, 12, and 36months. Higher domain scores indicate better function. Minimal clinically important difference was defined as 6 for urinary incontinence, 5 for urinary irritative function, 4 for bowel function, 12 for sexual function, and 4 for hormonal function. Multivariable linear and logistic regression models were fit to estimate the effect of treatment on patient-reported outcomes.ResultsFive-hundred seventy-eight men received EBRT and 109 received EB-LDR. Median patient age was 69years, and 70% had intermediate- or high-risk disease. Men in the EB-LDR group were younger (P<.001) and less likely to receive androgen deprivation therapy (P<.001). Baseline urinary, bowel, sexual, and hormonal function was similar between treatment groups (P>.05). On multivariable analyses, men receiving EB-LDR reported worse urinary irritative function at 6months (adjusted mean difference [AMD] -14.4, P<.001), 12months (AMD -12.9, P<.001), and 36months (AMD -4.7, P=.034) than men receiving EBRT. At 12months, men receiving EB-LDR reported worse bowel function (AMD -5.8, P=.002), but these differences were not seen at 36months. There were no significant differences in sexual or hormone function between treatment groups.ConclusionsMen treated with EB-LDR report worse bowel function at 1year and worse urinary irritative function through 3years compared with men treated with EBRT alone. These side effect profiles should be discussed with patients when considering EB-LDR versus EBRT ... |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
qt7rp56715; https://escholarship.org/uc/item/7rp56715Test |
| الإتاحة: |
https://escholarship.org/uc/item/7rp56715Test |
| حقوق: |
public |
| رقم الانضمام: |
edsbas.D060504B |
| قاعدة البيانات: |
BASE |
