المؤلفون: Bonomi, Marco, Vezzoli, Valeria, Krausz, Csilla, Guizzardi, Fabiana, Vezzani, Silvia, Simoni, Manuela, Bassi, Ivan, Duminuco, Paolo, Di Iorgi, Natascia, Giavoli, Claudia, Pizzocaro, Alessandro, Russo, Gianni, Moro, Mirella, Fatti, Letizia, Ferlin, Alberto, Mazzanti, Laura, Zatelli, Maria Chiara, Cannavò, Salvo, Isidori, Andrea M., Pincelli, Angela Ida, Prodam, Flavia, Mancini, Antonio, Limone, Paolo, Tanda, Maria Laura, Gaudino, Rossella, Salerno, Mariacarolina, Francesca, Pregnolato, Maghnie, Mohamad, Maggi, Mario, Persani, Luca, Aimaretti, G., Altobell, M., Ambrosio, M. R., Andrioli, M., Angelett, G., Arecco, F., Arnald, G., Arosio, M., Balsamo, A., Baldassarr, M., Bartalena, L., Bazzon, N., Beccari, L., Beck-Peccoz, P., Bellastella, G., Bellizz, M., Benedicent, F., Bernasconi, S., Bizzarri, C., Bona, G., Bonadonna, S., Borrett, G., Boschetti, M., Brunani, A., Brunelli, V., Buz, F., Cacciatore, C., Cangiano, B., Cappa, M., Casalone, R., Cassio, A., Cavarzere, P., Cherubini, V., Ciampani, T., Cicognan, D., Cignarell, A., Cisternin, M., Colombo, P., Corbetta, S., Corciul, N., Corona, G., Cozzi, R., Crivellaro, C., Dalle Mule, I., Danesi, L., Eli, A. V. D., Degli Uberti, E., De Leo, S., Della Valle, E., De Marchi, M., Di Iorgi, N., Di Mambr, A., Fabbri, A., Foresta, C., Forti, G., Franceschi, A. R., Garolla, A., Ghezzi, M., Giacomozzi, C., Giusti, M., Grosso, E., Guabello, G., Guarneri, M. P., Grugni, G., Isidori, A. M., Lanfranco, F., Lania, A., Lanzi, R., Larizza, L., Lenzi, A., Loche, S., Loli, P., Lombardi, V., Maggi, M. C., Mandrile, G., Manieri, C., Mantovani, G., Marelli, S., Marzullo, M., Mencarelli, M. A., Migone, N., Motta, G., Neri, G., Padov, G., Parenti, G., Pasquino, B., Pia, A., Piantanida, E., Pignatti, E., Pilotta, A., Pivett, B., Pollazzon, M., Pontecorvi, A., Porcelli, P., Pozza, G. B., Pozzobon, G., Radetti, G., Razzore, P., Rocchett, L., Roncoron, R., Rossi, G., Sala, E., Salvatoni, A., Salvini, F., Secc, A., Segni, M., Selice, R., Sgaramella, P., Sileo, F., Sinisi, A. A., Sirchia, F., Spada, A., Tresoldi, A., Vigneri, R., Weber, G., Zucchini, S.

المساهمون: Bonomi, Marco, Vezzoli, Valeria, Krausz, Csilla, Guizzardi, Fabiana, Vezzani, Silvia, Simoni, Manuela, Bassi, Ivan, Duminuco, Paolo, Di Iorgi, Natascia, Giavoli, Claudia, Pizzocaro, Alessandro, Russo, Gianni, Moro, Mirella, Fatti, Letizia, Ferlin, Alberto, Mazzanti, Laura, Zatelli, Maria Chiara, Cannavò, Salvo, Isidori, Andrea M., Pincelli, Angela Ida, Prodam, Flavia, Mancini, Antonio, Limone, Paolo, Tanda, Maria Laura, Gaudino, Rossella, Salerno, Mariacarolina, Francesca, Pregnolato, Maghnie, Mohamad, Maggi, Mario, Persani, Luca, Aimaretti, G., Altobell, M., Ambrosio, M.R., Andrioli, M., Angelett, G., Arecco, F., Arnald, G., Arosio, M., Balsamo, A., Baldassarr, M., Bartalena, L., Bazzon, N., Beccari, L., Beck-Peccoz, P., Bellastella, G., Bellizz, M., Benedicent, F., Bernasconi, S., Bizzarri, C., Bona, G., Bonadonna, S., Borrett, G., Boschetti, M., Brunani, A., Brunelli, V., Buz, F., Cacciatore, C., Cangiano, B., Cappa, M., Casalone, R., Cassio, A., Cavarzere, P., Cherubini, V., Ciampani, T., Cicognan, D., Cignarell, A., Cisternin, M., Colombo, P., Corbetta, S., Corciul, N., Corona, G., Cozzi, R., Crivellaro, C., Dalle Mule, I., Danesi, L., Eli, A.V.D., Degli Uberti, E., De Leo, S., Della Valle, E., De Marchi, M., Di Iorgi, N., Di Mambr, A., Fabbri, A., Foresta, C., Forti, G., Franceschi, A.R., Garolla, A., Ghezzi, M., Giacomozzi, C., Giusti, M., Grosso, E., Guabello, G., Guarneri, M.P., Grugni, G., Isidori, A.M., Lanfranco, F., Lania, A., Lanzi, R., Larizza, L., Lenzi, A.

مصطلحات موضوعية: Adolescent, Adult, Age of Onset, Cohort Studie, Female, Gonadal Steroid Hormone, Gonadotropin, Human, Hypogonadism, Italy, Male, Obesity, Olfaction Disorder, Overweight, Phenotype, Pituitary Hormone, Synkinesi, Young Adult, Endocrinology, Diabetes and Metabolism

الوصف: OBJECTIVE: Isolated hypogonadotropic hypogonadism (IHH) is a rare disorder with pubertal delay, normal (normoosmic-IHH, nIHH) or defective sense of smell (Kallmann syndrome, KS). Other reproductive and non-reproductive anomalies might be present although information on their frequency are scanty, particularly according to the age of presentation. DESIGN: Observational cohort study carried out between January 2008 and June 2016 within a national network of academic or general hospitals. METHODS: We performed a detailed phenotyping of 503 IHH patients with: (1) manifestations of hypogonadism with low sex steroid hormone and low/normal gonadotropins; (2) absence of expansive hypothalamic/pituitary lesions or multiple pituitary hormone defects. Cohort was divided on IHH onset (PPO, pre-pubertal onset or AO, adult onset) and olfactory function: PPO-nIHH (n = 275), KS (n = 184), AO-nIHH (n = 36) and AO-doIHH (AO-IHH with defective olfaction, n = 8). RESULTS: 90% of patients were classified as PPO and 10% as AO. Typical midline and olfactory defects, bimanual synkinesis and familiarity for pubertal delay were also found among the AO-IHH. Mean age at diagnosis was significantly earlier and more frequently associated with congenital hypogonadism stigmata in patients with Kallmann's syndrome (KS). Synkinesis, renal and male genital tract anomalies were enriched in KS. Overweight/obesity are significantly associated with AO-IHH rather than PPO-IHH. CONCLUSIONS: Patients with KS are more prone to develop a severe and complex phenotype than nIHH. The presence of typical extra-gonadal defects and familiarity for PPO-IHH among the AO-IHH patients indicates a common predisposition with variable clinical expression. Overall, these findings improve the understanding of IHH and may have a positive impact on the management of patients and their families.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/28882981; info:eu-repo/semantics/altIdentifier/wos/WOS:000419119500008; volume:178; issue:1; firstpage:23; lastpage:32; numberofpages:10; journal:EUROPEAN JOURNAL OF ENDOCRINOLOGY; http://hdl.handle.net/2318/1663108Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85040464673; http://www.eje-online.org/content/178/1/23.full.pdf+htmlTest

الإتاحة: https://doi.org/10.1530/EJE-17-0065Test
http://hdl.handle.net/2318/1663108Test
http://www.eje-online.org/content/178/1/23.full.pdf+htmlTest

المؤلفون: Prigge R., McKnight J.A., Wild S.H., Haynes A., Jones T.W., Davis E.A., Rami-Merhar B., Fritsch M., Prchla C., Lavens A., Doggen K., Chao S., Aronson R., Brown R., Ibfelt E.H., Svensson J., Young R., Warner J.T., Robinson H., Laatikainen T., Rautiainen P., Delemer B., Souchon P.F., Diallo A.M., Holl R.W., Schmid S.M., Raile K., Tigas S., Bargiota A., Zografou I., Luk A.O.Y., Chan J.C.N., Dinneen S.F., Buckley C.M., Kgosidialwa O., Cherubini V., Gesuita R., Strele I., Pildava S., Veeze H., Aanstoot H.-J., Mul D., Jefferies C., Cooper J.G., Løvaas K.F., Battelino T., Dovc K., Bratina N., Eeg-Olofsson K., Svensson A.-M., Gudbjornsdottir S., Globa E., Zelinska N.

المصدر: Diabetic Medicine ; https://www.scopus.com/inward/record.uri?eid=2-s2.0-85128493437&doi=10.1111%2fdme.14766&partnerID=40&md5=0e6f490887adb4afa17baff2877bf93cTest

مصطلحات موضوعية: hemoglobin A1c, glycosylated hemoglobin, adolescent, adult, age, Article, controlled study, cross-sectional study, diabetic patient, female, glycemic control, hemoglobin blood level, human, insulin dependent diabetes mellitus, major clinical study, male, retrospective study, sex difference, young adult, child, glucose blood level, Blood Glucose, Cross-Sectional Studies, Diabetes Mellitus, Type 1, Glycated Hemoglobin A, Humans, John Wiley and Sons Inc

الوصف: Aims: To update and extend a previous cross-sectional international comparison of glycaemic control in people with type 1 diabetes. Methods: Data were obtained for 520,392 children and adults with type 1 diabetes from 17 population and five clinic-based data sources in countries or regions between 2016 and 2020. Median HbA1c(IQR) and proportions of individuals with HbA1c < 58 mmol/mol (<7.5%), 58–74 mmol/mol (7.5–8.9%) and ≥75 mmol/mol (≥9.0%) were compared between populations for individuals aged <15, 15–24 and ≥25 years. Logistic regression was used to estimate the odds ratio (OR) of HbA1c < 58 mmol/mol (<7.5%) relative to ≥58 mmol/mol (≥7.5%), stratified and adjusted for sex, age and data source. Where possible, changes in the proportion of individuals in each HbA1c category compared to previous estimates were calculated. Results: Median HbA1c varied from 55 to 79 mmol/mol (7.2 to 9.4%) across data sources and age groups so a pooled estimate was deemed inappropriate. OR (95% CI) for HbA1c< 58 mmol/mol (<7.5%) were 0.91 (0.90–0.92) for women compared to men, 1.68 (1.65–1.71) for people aged <15 years and 0.81 (0.79–0.82) aged15–24 years compared to those aged ≥25 years. Differences between populations persisted after adjusting for sex, age and data source. In general, compared to our previous analysis, the proportion of people with an HbA1c < 58 mmol/l (<7.5%) increased and proportions of people with HbA1c≥ 75 mmol/mol (≥9.0%) decreased. Conclusions: Glycaemic control of type 1 diabetes continues to vary substantially between age groups and data sources. While some improvement over time has been observed, glycaemic control remains sub-optimal for most people with Type 1 diabetes. © 2021 Diabetes UK.

العلاقة: http://hdl.handle.net/11615/78370Test

الإتاحة: https://doi.org/10.1111/dme.14766Test
http://hdl.handle.net/11615/78370Test

المؤلفون: Cherubini V., Gesuita R., Skrami E., Rabbone I., Bonfanti R., Arnaldi C., D'Annunzio G., Frongia A., Lombardo F., Piccinno E., Schiaffini R., Toni S., Tumini S., Tinti D., Cipriano P., Minuto N., Lenzi L., Ferrito L., Ventrici C., Ortolani F., Cohen O., Scaramuzza A.

المساهمون: Cherubini, V., Gesuita, R., Skrami, E., Rabbone, I., Bonfanti, R., Arnaldi, C., D'Annunzio, G., Frongia, A., Lombardo, F., Piccinno, E., Schiaffini, R., Toni, S., Tumini, S., Tinti, D., Cipriano, P., Minuto, N., Lenzi, L., Ferrito, L., Ventrici, C., Ortolani, F., Cohen, O., Scaramuzza, A.

مصطلحات موضوعية: CGM, continuous glucose monitoring, continuous subcutaneous insulin infusion, insulin pump therapy, predictive low glucose suspend, SAP, thresholds, Adolescent, Adult, Blood Glucose, Blood Glucose Self-Monitoring, Calibration, Diabetes Mellitus, Type 1, Exercise, Female, Humans, Hypoglycemia, Injections, Subcutaneous, Insulin, Insulin Infusion Systems, Male, Preventive Medicine, Young Adult

الوصف: Objectives: To assess the optimal setting of the predictive low glucose management (PLGM) algorithm for preventing exercise-induced hypoglycemia in adolescents with type 1 diabetes. Methods: Thirty-four adolescents, 15 to 20 years, wearing PLGM system, were followed during 3 days exercise during a diabetes camp. PLGM threshold was set at 70 mg/dL between 8 am and 10 pm and 90 mg/dL during 10 pm and 8 am Adolescents were divided into group A and B, with PLGM threshold at 90 and 70 mg/dL, respectively, during exercise. Time spent in hypoglycemia and AUC for time slots 8 am to 1 pm, 1 to 4 pm, 4 to 11 pm, 11 pm to 3 am, 3 to 8 am, in 3 days were compared between groups by Wilcoxon rank sum test. Results: We analyzed 31 patients (median age 15.0 years, 58.1% males, median diabetes duration 7.0 years, hemoglobin A1c [HbA1c] 7.1%). No significant difference has been observed in time spent in hypoglycemia between groups using threshold 70 or 90. Time spent in target was similar in both groups, as well as time spent in hypo or hyperglycemia. The trends of blood glucose over the 3 days in the 2 groups over-lapped without significant differences. Conclusions: A PLGM threshold of 90 mg/dL during the night was associated with reduced time in hypoglycemia in adolescents doing frequent physical exercise, while maintaining 65.1% time in range during the day. However, a threshold of 70 mg/dL seems to be safe in the duration of the physical exercise. PLGM system in adolescents with type 1 diabetes was effective to prevent hypoglycemia during and after exercise, irrespective of the PLGM thresholds used.

العلاقة: info:eu-repo/semantics/altIdentifier/wos/WOS:000455490600015; volume:20; issue:1; firstpage:107; lastpage:112; numberofpages:6; journal:PEDIATRIC DIABETES; http://hdl.handle.net/20.500.11768/126655Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85056876879

الإتاحة: https://doi.org/20.500.11768/126655Test
https://doi.org/10.1111/pedi.12792Test
https://hdl.handle.net/20.500.11768/126655Test

المؤلفون: Di Bartolo P., Nicolucci A., Cherubini V., Iafusco D., Scardapane M., Rossi M. C.

المساهمون: Di Bartolo, P., Nicolucci, A., Cherubini, V., Iafusco, D., Scardapane, M., Rossi, M. C.

مصطلحات موضوعية: Compliance, Self-monitoring blood glucose, Telemedicine, Type 1 diabete, Adolescent, Adult, Age Factor, Biosensing Technique, Blood Glucose, Blood Glucose Self-Monitoring, Diabetes Mellitus, Type 1, Female, Glycated Hemoglobin A, Human, Hypoglycemic Agent, Insulin, Male, Patient Compliance, Quality of Life, Young Adult

الوصف: Aims: To compare iBGStarTM+DMApp (experimental meter+telemedicine system) (iBGStar) with a traditional glucose meter (Control) in type 1 diabetes adolescents/young adults. Methods: i-NewTrend was a multicenter, open-label, randomized trial involving subjects aged 14–24years, on basal–bolus insulin, HbA1c≥8.0%, and poorly compliant with SMBG (i.e., <30% of the recommended frequency). Primary end points were change in HbA1c and achievement of compliance with SMBG (≥30% of the recommended frequency) after 6months. Quality of life was also evaluated. A post-trial observational phase was conducted, where both groups used the experimental device. Results: Of 182 randomized patients (51.1% male; age 17.7±3.0years; diabetes duration 8.8±4.7years; HbA1c levels 10.0%±1.4), 92 were allocated to iBGStar and 90 to Control; 6.5% in iBGStar and 8.9% in Control dropped-out. After 6months, HbA1c changes (±SE) were −0.44%±0.13 in iBGStar and −0.32%±0.13 in Control (p=0.51). In the post-trial phase, HbA1c changes from 6months (±SE) were −0.07%±0.14 in iBGStar and −0.31%±0.14 in Control (p=0.24). Compliance end point was reached by 53.6% in iBGStar and 55.0% in Control (p=0.86). Mean daily SMBG measurements increased from 1.1 to 2.3 in both groups without worsening quality of life. Compliant subjects showed a greater reduction in HbA1c levels (−0.60%±0.23 in iBGStar; −0.41%±0.21 in Control; p=0.31). Within iBGStar group, telemedicine users (38.0%) reduced HbA1c by −0.58±0.18. Conclusions: iBGStar was not superior to the traditional meter. Irrespective of the strategy, increasing from 1 to 2 SMBG tests/day was associated with HbA1c reduction in both groups, without pharmacologic interventions. Identifying new technologies effective and acceptable to patients is an option to improve adherence to diabetes care. Trial registration: The trial was registered at ClinicalTrials.gov (registration number NCT02073188).

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/28138788; info:eu-repo/semantics/altIdentifier/wos/WOS:000398602300009; volume:54; issue:4; firstpage:393; lastpage:402; numberofpages:10; journal:ACTA DIABETOLOGICA; http://hdl.handle.net/11591/409374Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85011003141; link.springer.de/link/service/journals/00592/index.htm

الإتاحة: https://doi.org/10.1007/s00592-017-0963-4Test
http://hdl.handle.net/11591/409374Test

المؤلفون: Gerasimidi Vazeou, A, Kordonouri, O, Witsch, M, Hermann, J M, Forsander, G, de Beaufort, C, Veeze, H J, Maffeis, C, Cherubini, V, Cinek, O, Piccini, B, Holl, R W, Danne, T

المساهمون: Gerasimidi Vazeou, A, Kordonouri, O, Witsch, M, Hermann, J M, Forsander, G, de Beaufort, C, Veeze, H J, Maffeis, C, Cherubini, V, Cinek, O, Piccini, B, Holl, R W, Danne, T

مصطلحات موضوعية: SWEET centre, SWEET database, seasonality, type 1 diabete, type 1 diabetes etiopathogenesi, Adolescent, Child, Preschool, Cohort Studie, Diabetes Mellitus, Type 1, Europe, Female, Human, Infant, Male, Young Adult, Seasons

الوصف: Background: Seasonality at the clinical onset of type 1 diabetes (T1D) has been suggested by different studies, however, the results are conflicting. This study aimed to evaluate the presence of seasonality at clinical onset of T1D based on the SWEET database comprising data from 32 different countries. Methods: The study cohort included 23 603 patients (52% males) recorded in the international multicenter SWEET database (48 centers), with T1D onset ≤20 years, year of onset between 1980 and 2015, gender, year and month of birth and T1D-diagnosis documented. Data were stratified according to four age groups (<5, 5-<10, 10-<15, 15-20 years) at T1D onset, the latitude of European center (Northern ≥50°N and Southern Europe <50°N) and the year of onset ≤ or >2009. Results: Analysis by month revealed significant seasonality with January being the month with the highest and June with the lowest percentage of incident cases (P <.001). Winter, early spring and late autumn months had higher percentage of incident cases compared with late spring and summer months. Stratification by age showed similar seasonality patterns in all four age groups (P ≤.003 each), but not in children <24 months of age. There was no gender or latitude effect on seasonality pattern, however, the pattern differed by the year of onset (P <.001). Seasonality of diagnosis conformed to a sinusoidal model for all cases, females and males, age groups, northern and southern European countries. Conclusions: Seasonality at T1D clinical onset is documented by the large SWEET database with no gender or latitude (Europe only) effect except from the year of manifestation.

وصف الملف: STAMPA

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/28334496; info:eu-repo/semantics/altIdentifier/wos/WOS:000389153800005; volume:17; issue:S23; firstpage:32; lastpage:37; numberofpages:6; journal:PEDIATRIC DIABETES; http://hdl.handle.net/11562/972876Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84992371576

الإتاحة: https://doi.org/10.1111/pedi.12433Test
http://hdl.handle.net/11562/972876Test

المؤلفون: Andrea Scaramuzza, Claudia Ventrici, Valentino Cherubini, Riccardo Schiaffini, Sonia Toni, Federica Ortolani, Davide Tinti, Stefano Tumini, Paola Cipriano, Edlira Skrami, Nicola Minuto, Giuseppe d'Annunzio, Ivana Rabbone, Rosaria Gesuita, Riccardo Bonfanti, Fortunato Lombardo, C. Arnaldi, Lorenzo Lenzi, Lucia Ferrito, Annapaola Frongia, Elvira Piccinno, Ohad Cohen

المساهمون: Cherubini, V., Gesuita, R., Skrami, E., Rabbone, I., Bonfanti, R., Arnaldi, C., D'Annunzio, G., Frongia, A., Lombardo, F., Piccinno, E., Schiaffini, R., Toni, S., Tumini, S., Tinti, D., Cipriano, P., Minuto, N., Lenzi, L., Ferrito, L., Ventrici, C., Ortolani, F., Cohen, O., Scaramuzza, A.

المصدر: Pediatric Diabetes. 20:107-112

مصطلحات موضوعية: Blood Glucose, Male, Diabetes duration, Endocrinology, Diabetes and Metabolism, insulin pump therapy, Pediatrics, Low glucose, Endocrinology, 0302 clinical medicine, Insulin, Medicine, 030212 general & internal medicine, continuous subcutaneous insulin infusion, Continuous glucose monitoring, CGM, continuous glucose monitoring, continuous subcutaneous insulin infusion, insulin pump therapy, predictive low glucose suspend, SAP, thresholds, Internal Medicine, Pediatrics, Perinatology and Child Health, Endocrinology, Diabetes and Metabolism, Perinatology and Child Health, Diabetes and Metabolism, Calibration, continuous glucose monitoring, Female, SAP, Adult, medicine.medical_specialty, Adolescent, Injections, Subcutaneous, 030209 endocrinology & metabolism, Physical exercise, Hypoglycemia, Young Adult, 03 medical and health sciences, Insulin Infusion Systems, Internal medicine, Diabetes mellitus, Internal Medicine, Humans, Exercise, Type 1 diabetes, predictive low glucose suspend, CGM, business.industry, Blood Glucose Self-Monitoring, Significant difference, thresholds, medicine.disease, Diabetes Mellitus, Type 1, Pediatrics, Perinatology and Child Health, Preventive Medicine, business

الوصف: Objectives To assess the optimal setting of the predictive low glucose management (PLGM) algorithm for preventing exercise-induced hypoglycemia in adolescents with type 1 diabetes. Methods Thirty-four adolescents, 15 to 20 years, wearing PLGM system, were followed during 3 days exercise during a diabetes camp. PLGM threshold was set at 70 mg/dL between 8 am and 10 pm and 90 mg/dL during 10 pm and 8 am Adolescents were divided into group A and B, with PLGM threshold at 90 and 70 mg/dL, respectively, during exercise. Time spent in hypoglycemia and AUC for time slots 8 am to 1 pm, 1 to 4 pm, 4 to 11 pm, 11 pm to 3 am, 3 to 8 am, in 3 days were compared between groups by Wilcoxon rank sum test. Results We analyzed 31 patients (median age 15.0 years, 58.1% males, median diabetes duration 7.0 years, hemoglobin A1c [HbA1c] 7.1%). No significant difference has been observed in time spent in hypoglycemia between groups using threshold 70 or 90. Time spent in target was similar in both groups, as well as time spent in hypo or hyperglycemia. The trends of blood glucose over the 3 days in the 2 groups over-lapped without significant differences. Conclusions A PLGM threshold of 90 mg/dL during the night was associated with reduced time in hypoglycemia in adolescents doing frequent physical exercise, while maintaining 65.1% time in range during the day. However, a threshold of 70 mg/dL seems to be safe in the duration of the physical exercise. PLGM system in adolescents with type 1 diabetes was effective to prevent hypoglycemia during and after exercise, irrespective of the PLGM thresholds used.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c09b637f7f59a60b4c03c068892877c0Test
https://doi.org/10.1111/pedi.12792Test

المؤلفون: D. Iafusco, Marco Scardapane, Maria Chiara Rossi, Antonio Nicolucci, Paolo Di Bartolo, Valentino Cherubini

المساهمون: Di Bartolo, P., Nicolucci, A., Cherubini, V., Iafusco, D., Scardapane, M., Rossi, M. C.

المصدر: Acta Diabetologica. 54:393-402

مصطلحات موضوعية: Blood Glucose, Male, Glycated Hemoglobin A, Endocrinology, Diabetes and Metabolism, Biosensing Techniques, law.invention, 0302 clinical medicine, Endocrinology, Randomized controlled trial, Quality of life, law, Insulin, Age Factor, 030212 general & internal medicine, Young adult, Glucose meter, Age Factors, General Medicine, Telemedicine, Self-monitoring blood glucose, Female, Compliance, Human, Adult, medicine.medical_specialty, Type 1 diabete, Adolescent, 030209 endocrinology & metabolism, Biosensing Technique, Young Adult, 03 medical and health sciences, Internal medicine, Diabetes mellitus, Blood Glucose Self-Monitoring, Internal Medicine, medicine, Humans, Hypoglycemic Agents, Intensive care medicine, Glycated Hemoglobin, Type 1 diabetes, Hypoglycemic Agent, business.industry, medicine.disease, Diabetes Mellitus, Type 1, Quality of Life, Patient Compliance, Observational study, business

الوصف: Aims: To compare iBGStar™+DMApp (experimental meter+telemedicine system) (iBGStar) with a traditional glucose meter (Control) in type 1 diabetes adolescents/young adults. Methods: i-NewTrend was a multicenter, open-label, randomized trial involving subjects aged 14–24years, on basal–bolus insulin, HbA1c≥8.0%, and poorly compliant with SMBG (i.e.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d701fd0a7bc79eae7084b6b89c9d5d5Test
https://doi.org/10.1007/s00592-017-0963-4Test

المؤلفون: Bassi I., Moro M., Pincelli A. I., Mancini A., Cappa M., Corbetta S., Corona G., Danesi L., Ghezzi M., Giusti M., Grugni G., Parenti G., Pontecorvi A., Sala E.

المساهمون: Bonomi, M., Vezzoli, V., Krausz, C., Guizzardi, F., Vezzani, S., Simoni, M., Bassi, I., Duminuco, P., Di Iorgi, N., Giavoli, C., Pizzocaro, A., Russo, G., Moro, M., Fatti, L., Ferlin, A., Mazzanti, L., Zatelli, M. C., Cannavo, S., Isidori, A. M., Pincelli, A. I., Prodam, F., Mancini, A., Limone, P., Tanda, M. L., Gaudino, R., Salerno, M., Francesca, P., Maghnie, M., Maggi, M. C., Persani, L., Aimaretti, G., Altobell, M., Ambrosio, M. R., Andrioli, M., Angelett, G., Arecco, F., Arnald, G., Arosio, M., Balsamo, A., Baldassarr, M., Bartalena, L., Bazzon, N., Beccari, L., Beck-Peccoz, P., Bellastella, G., Bellizz, M., Benedicent, F., Bernasconi, S., Bizzarri, C., Bona, G., Bonadonna, S., Borrett, G., Boschetti, M., Brunani, A., Brunelli, V., Buz, F., Cacciatore, C., Cangiano, B., Cappa, M., Casalone, R., Cassio, A., Cavarzere, P., Cherubini, V., Ciampani, T., Cicognan, D., Cignarell, A., Cisternin, M., Colombo, P., Corbetta, S., Corciul, N., Corona, G., Cozzi, R., Crivellaro, C., Dalle Mule, I., Danesi, L., Eli, A. V. D., Degli Uberti, E., De Leo, S., Della Valle, E., De Marchi, M., Di Mambr, A., Fabbri, A., Foresta, C., Forti, G., Franceschi, A. R., Garolla, A., Ghezzi, M., Giacomozzi, C., Giusti, M., Grosso, E., Guabello, G., Guarneri, M. P., Grugni, G., Lanfranco, F., Lania, A., Lanzi, R., Larizza, L., Lenzi, A., Loche, S., Loli, P.

مصطلحات موضوعية: Adolescent, Adult, Age of Onset, Cohort Studies, Female, Gonadal Steroid Hormones, Gonadotropins, Humans, Hypogonadism, Italy, Male, Obesity, Olfaction Disorders, Overweight, Phenotype, Pituitary Hormones, Synkinesis, Young Adult, Settore MED/13 - ENDOCRINOLOGIA

الوصف: Objective: Isolated hypogonadotropic hypogonadism (IHH) is a rare disorder with pubertal delay, normal (normoosmic-IHH, nIHH) or defective sense of smell (Kallmann syndrome, KS). Other reproductive and nonreproductive anomalies might be present although information on their frequency are scanty, particularly according to the age of presentation. Design: Observational cohort study carried out between January 2008 and June 2016 within a national network of academic or general hospitals. Methods: We performed a detailed phenotyping of 503 IHH patients with: (1) manifestations of hypogonadism with low sex steroid hormone and low/normal gonadotropins; (2) absence of expansive hypothalamic/pituitary lesions or multiple pituitary hormone defects. Cohort was divided on IHH onset (PPO, pre-pubertal onset or AO, adult onset) and olfactory function: PPO-nIHH (n = 275), KS (n = 184), AO-nIHH (n = 36) and AO-doIHH (AO-IHH with defective olfaction, n = 8). Results: 90% of patients were classifed as PPO and 10% as AO. Typical midline and olfactory defects, bimanual synkinesis and familiarity for pubertal delay were also found among the AO-IHH. Mean age at diagnosis was signifcantly earlier and more frequently associated with congenital hypogonadism stigmata in patients with Kallmann's syndrome (KS). Synkinesis, renal and male genital tract anomalies were enriched in KS. Overweight/obesity are signifcantly associated with AO-IHH rather than PPO-IHH. Conclusions: Patients with KS are more prone to develop a severe and complex phenotype than nIHH. The presence of typical extra-gonadal defects and familiarity for PPO-IHH among the AO-IHH patients indicates a common predisposition with variable clinical expression. Overall, these fndings improve the understanding of IHH and may have a positive impact on the management of patients and their families.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/28882981; info:eu-repo/semantics/altIdentifier/wos/WOS:000419119500008; volume:178; issue:1; firstpage:23; lastpage:32; numberofpages:10; issueyear:2018; journal:EUROPEAN JOURNAL OF ENDOCRINOLOGY; http://hdl.handle.net/10807/170010Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85040464673

الإتاحة: https://doi.org/10.1530/EJE-17-0065Test
http://hdl.handle.net/10807/170010Test

المؤلفون: Marco Bonomi, Valeria Vezzoli, Csilla Krausz, Fabiana Guizzardi, Silvia Vezzani, Manuela Simoni, Ivan Bassi, Paolo Duminuco, Natascia Di Iorgi, Claudia Giavoli, Alessandro Pizzocaro, Gianni Russo, Mirella Moro, Letizia Fatti, Alberto Ferlin, Laura Mazzanti, Maria Chiara Zatelli, Salvo Cannavò, Andrea M Isidori, Angela Ida Pincelli, Flavia Prodam, Antonio Mancini, Paolo Limone, Maria Laura Tanda, Rossella Gaudino, Mariacarolina Salerno, Pregnolato Francesca, Mohamad Maghnie, Mario Maggi, Luca Persani, G Aimaretti, M Altobelli, M R Ambrosio, M Andrioli, G Angeletti, F Arecco, G Arnaldi, M Arosio, A Balsamo, M Baldassarri, L Bartalena, N Bazzoni, L Beccaria, P Beck-Peccoz, G Bellastella, M Bellizzi, F Benedicenti, S Bernasconi, C Bizzarri, G Bona, S Bonadonna, G Borretta, M Boschetti, A Brunani, V Brunelli, F Buzi, C Cacciatore, B Cangiano, M Cappa, R Casalone, A Cassio, P Cavarzere, V Cherubini, T Ciampani, D Cicognani, A Cignarelli, M Cisternino, P Colombo, S Corbetta, N Corciulo, G Corona, R Cozzi, C Crivellaro, I Dalle Mule, L Danesi, A V D’Elia, E degli Uberti, S De Leo, E Della Valle, M De Marchi, N Di Iorgi, A Di Mambro, A Fabbri, C Foresta, G Forti, A R Franceschi, A Garolla, M Ghezzi, C Giacomozzi, M Giusti, E Grosso, G Guabello, M P Guarneri, G Grugni, A M Isidori, F Lanfranco, A Lania, R Lanzi, L Larizza, A Lenzi, S Loche, P Loli, V Lombardi, M C Maggio, G Mandrile, C Manieri, G Mantovani, S Marelli, M Marzullo, M A Mencarelli, N Migone, G Motta, G Neri, G Padova, G Parenti, B Pasquino, A Pia, E Piantanida, E Pignatti, A Pilotta, B Pivetta, M Pollazzon, A Pontecorvi, P Porcelli, G B Pozzan, G Pozzobon, G Radetti, P Razzore, L Rocchetti, R Roncoroni, G Rossi, E Sala, A Salvatoni, F Salvini, A Secco, M Segni, R Selice, P Sgaramella, F Sileo, A A Sinisi, F Sirchia, A Spada, A Tresoldi, R Vigneri, G Weber, S Zucchini

المساهمون: Bonomi, Marco, Vezzoli, Valeria, Krausz, Csilla, Guizzardi, Fabiana, Vezzani, Silvia, Simoni, Manuela, Bassi, Ivan, Duminuco, Paolo, Di Iorgi, Natascia, Giavoli, Claudia, Pizzocaro, Alessandro, Russo, Gianni, Moro, Mirella, Fatti, Letizia, Ferlin, Alberto, Mazzanti, Laura, Zatelli Maria, Chiara, Cannavò, Salvo, Isidori Andrea, M., Pincelli Angela, Ida, Prodam, Flavia, Mancini, Antonio, Limone, Paolo, Tanda Maria, Laura, Gaudino, Rossella, Salerno, Mariacarolina, Francesca, Pregnolato, Maghnie, Mohamad, Maggi, Mario, Persani, Luca, Italian Network on Central, Hypogonadism., Zatelli, Maria Chiara, Cannavã², Salvo, Isidori, Andrea M., Pincelli, Angela Ida, Tanda, Maria Laura, Aimaretti, G., Altobell, M., Ambrosio, M. R., Andrioli, M., Angelett, G., Arecco, F., Arnald, G., Arosio, M., Balsamo, A., Baldassarr, M., Bartalena, L., Bazzon, N., Beccari, L., Beck-Peccoz, P., Bellastella, G., Bellizz, M., Benedicent, F., Bernasconi, S., Bizzarri, C., Bona, G., Bonadonna, S., Borrett, G., Boschetti, M., Brunani, A., Brunelli, V., Buz, F., Cacciatore, C., Cangiano, B., Cappa, M., Casalone, R., Cassio, A., Cavarzere, P., Cherubini, V., Ciampani, T., Cicognan, D., Cignarell, A., Cisternin, M., Colombo, P., Corbetta, S., Corciul, N., Corona, G., Cozzi, R., Crivellaro, C., Dalle Mule, I., Danesi, L., Eli, A. V. D., Degli Uberti, E., De Leo, S., Della Valle, E., De Marchi, M., Di Iorgi, N., Di Mambr, A., Fabbri, A., Foresta, C., Forti, G., Franceschi, A. R., Garolla, A., Ghezzi, M., Giacomozzi, C., Giusti, M., Grosso, E., Guabello, G., Guarneri, M. P., Grugni, G., Isidori, A. M., Lanfranco, F., Lania, A., Lanzi, R., Larizza, L., Lenzi, A., Loche, S., Loli, P., Lombardi, V., Maggi, M. C., Mandrile, G., Manieri, C., Mantovani, G., Marelli, S., Marzullo, M., Mencarelli, M. A., Migone, N., Motta, G., Neri, G., Padov, G., Parenti, G., Pasquino, B., Pia, A., Piantanida, E., Pignatti, E., Pilotta, A., Pivett, B., Pollazzon, M., Pontecorvi, A., Porcelli, P., Pozza, G. B., Pozzobon, G., Radetti, G., Razzore, P., Rocchett, L., Roncoron, R., Rossi, G., Sala, E., Salvatoni, A., Salvini, F., Secc, A., Segni, M., Selice, R., Sgaramella, P., Sileo, F., Sinisi, A. A., Sirchia, F., Spada, A., Tresoldi, A., Vigneri, R., Weber, G., Zucchini, S., Marco Bonomi, Valeria Vezzoli, Csilla Krausz, Fabiana Guizzardi, Silvia Vezzani, Manuela Simoni, Ivan Bassi, Paolo Duminuco, Natascia Di Iorgi, Claudia Giavoli, Alessandro Pizzocaro, Gianni Russo, Mirella Moro, Letizia Fatti, Alberto Ferlin, Laura Mazzanti, Maria Chiara Zatelli, Salvo Cannavò, Andrea M Isidori, Angela Ida Pincelli, Flavia Prodam, Antonio Mancini, Paolo Limone, Maria Laura Tanda, Rossella Gaudino, Mariacarolina Salerno, Pregnolato Francesca, Mohamad Maghnie, Mario Maggi, Luca Persani, Italian Network on Central Hypogonadism […, A. Cassio, …, S. Zucchini, ], Isidori, Andrea M, Weber, Giovanna, Italian Network on Central, Hypogonadism

مصطلحات موضوعية: 0301 basic medicine, Male, Pediatrics, Synkinesis, Kallmann syndrome, diagnosis, genotype, Endocrinology, Diabetes and Metabolism, Gonadal Steroid Hormone, Cohort Studies, Olfaction Disorders, 0302 clinical medicine, Endocrinology, Olfaction Disorder, Young adult, Age of Onset, Gonadal Steroid Hormones, Gonadotropin, Pituitary Hormone, Isolated hypogonadotropic hypogonadism, General Medicine, isolated hypogonadotropic hypogonadism, pubertal delay, genetic-basis, gonadotropin-deficiency, Diabetes and Metabolism, Phenotype, Italy, Cohort, Female, complex, Cohort study, Human, Adult, medicine.medical_specialty, Adolescent, Gonadotropins, Humans, Hypogonadism, Obesity, Overweight, Pituitary Hormones, Young Adult, 030209 endocrinology & metabolism, NO, 03 medical and health sciences, Hypogonadotropic hypogonadism, Adolescent, Adult, Age of Onset, Cohort Studies, Female, Gonadal Steroid Hormones, Gonadotropins, Humans, Hypogonadis, Italy, Male, Obesity, Olfaction Disorders, Overweight, Phenotype, Pituitary Hormones, Synkinesis, Young Adult, Endocrinology, Diabetes and Metabolism, Endocrinology, Internal medicine, medicine, Isolated hypogonadotropic hypogonadism, Kallmann syndrome, Observational cohort study, gnrh deficiency, disease, business.industry, Settore MED/13 - ENDOCRINOLOGIA, isolated Hypogonadotropic hypogonadism, kallmann syndrome, medicine.disease, body regions, 030104 developmental biology, Sex steroid, linked kallmann-syndrome, heterogeneity, phenotype, Observational cohort study, Synkinesi, Age of onset, Cohort Studie, business

الوصف: Objective Isolated hypogonadotropic hypogonadism (IHH) is a rare disorder with pubertal delay, normal (normoosmic-IHH, nIHH) or defective sense of smell (Kallmann syndrome, KS). Other reproductive and non-reproductive anomalies might be present although information on their frequency are scanty, particularly according to the age of presentation. Design Observational cohort study carried out between January 2008 and June 2016 within a national network of academic or general hospitals. Methods We performed a detailed phenotyping of 503 IHH patients with: (1) manifestations of hypogonadism with low sex steroid hormone and low/normal gonadotropins; (2) absence of expansive hypothalamic/pituitary lesions or multiple pituitary hormone defects. Cohort was divided on IHH onset (PPO, pre-pubertal onset or AO, adult onset) and olfactory function: PPO-nIHH (n = 275), KS (n = 184), AO-nIHH (n = 36) and AO-doIHH (AO-IHH with defective olfaction, n = 8). Results 90% of patients were classified as PPO and 10% as AO. Typical midline and olfactory defects, bimanual synkinesis and familiarity for pubertal delay were also found among the AO-IHH. Mean age at diagnosis was significantly earlier and more frequently associated with congenital hypogonadism stigmata in patients with Kallmann’s syndrome (KS). Synkinesis, renal and male genital tract anomalies were enriched in KS. Overweight/obesity are significantly associated with AO-IHH rather than PPO-IHH. Conclusions Patients with KS are more prone to develop a severe and complex phenotype than nIHH. The presence of typical extra-gonadal defects and familiarity for PPO-IHH among the AO-IHH patients indicates a common predisposition with variable clinical expression. Overall, these findings improve the understanding of IHH and may have a positive impact on the management of patients and their families.

وصف الملف: STAMPA

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f800b3107977776e40dbca2a965ea877Test
http://hdl.handle.net/11383/2066625Test

المؤلفون: Stefano Zucchini, Maria Antonietta Zedda, Ivana Rabbone, Sonia Toni, Andrea Scaramuzza, Lorenzo Iughetti, Dario Iafusco, Valeria Calcaterra, Valeria De Donno, Valentino Cherubini, Giuliana Cardinale, R. Lera, F. Gallo, Fortunato Lombardo, Claudio Maffeis, Giuliana Valerio, Fiorella De Berardinis, Adriana Franzese, Giovanni Federico, Mariella Bruzzese

المساهمون: Valerio, G, Maffeis, C, Zucchini, S, Lombardo, F, Toni, S, Rabbone, I, Federico, G, Scaramuzza, A, Franzese, A, Cherubini, V, Zedda, Ma, Calcaterra, V, Lera, R, Cardinale, G, Bruzzese, M, Iughetti, L, Gallo, F, De Donno, V, De Berardinis, F, Iafusco, Dario, Valerio, Giuliana, Maffeis, Claudio, Zucchini, Stefano, Lombardo, Fortunato, Toni, Sonia, Rabbone, Ivana, Federico, Giovanni, Scaramuzza, Andrea, Franzese, Adriana, Cherubini, Valentino, Zedda, Maria Antonietta, Calcaterra, Valeria, Lera, Riccardo, Cardinale, Giuliana, Bruzzese, Mariella, Iughetti, Lorenzo, Gallo, Francesco, De Donno, Valeria, De Berardinis, Fiorella

مصطلحات موضوعية: Adult, Male, Pediatric Obesity, medicine.medical_specialty, Pediatrics, Adolescent, Endocrinology, Diabetes and Metabolism, TYPE I (INSULIN-DEPENDENT) DIABETES MELLITUS, Geographic variation, Young Adult, Endocrinology, Internal medicine, Diabetes mellitus, Prevalence, Internal Medicine, medicine, Humans, Young adult, Metabolic Syndrome, Type 1 diabetes, Geography, Metabolic Syndrome X, General Medicine, medicine.disease, Obesity, Diabetes Mellitus, Type 1, Italy, Obesity, Abdominal, Female, Metabolic syndrome, Human

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c977d8aa71aae40184fad1609ea7a65Test
http://hdl.handle.net/11570/2557867Test