Pesticide exposure and risk of aggressive prostate cancer among private pesticide applicators
| العنوان: | Pesticide exposure and risk of aggressive prostate cancer among private pesticide applicators |
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| المؤلفون: | Jay H. Lubin, Christine G. Parks, Stella Koutros, Jonathan N. Hofmann, Gabriella Andreotti, Larissa A. Pardo, Catherine C. Lerro, Laura E. Beane Freeman, Aaron Blair, Dale P. Sandler |
| المصدر: | Environmental Health, Vol 19, Iss 1, Pp 1-12 (2020) Environmental Health |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Health, Toxicology and Mutagenesis, Young Adult, lcsh:RC963-969, 03 medical and health sciences, Prostate cancer, 0302 clinical medicine, Risk Factors, Internal medicine, North Carolina, Prevalence, medicine, Humans, Prospective Studies, Pesticides, Stage (cooking), Family history, Prospective cohort study, Aged, 030304 developmental biology, 2. Zero hunger, 0303 health sciences, Proportional hazards model, business.industry, Research, Incidence, lcsh:Public aspects of medicine, Hazard ratio, Public Health, Environmental and Occupational Health, Prostatic Neoplasms, lcsh:RA1-1270, Aggressive prostate cancer (PCa), Middle Aged, Pesticide, medicine.disease, Iowa, Confidence interval, Agricultural Workers' Diseases, 3. Good health, 030220 oncology & carcinogenesis, lcsh:Industrial medicine. Industrial hygiene, Pesticide applicators, business, Organodithioate insecticides |
| الوصف: | Background Prostate cancer (PCa) is one of the most commonly diagnosed cancers among men in developed countries; however, little is known about modifiable risk factors. Some studies have implicated organochlorine and organophosphate insecticides as risk factors (particularly the organodithioate class) and risk of clinically significant PCa subtypes. However, few studies have evaluated other pesticides. We used data from the Agricultural Health Study, a large prospective cohort of pesticide applicators in North Carolina and Iowa, to extend our previous work and evaluate 39 additional pesticides and aggressive PCa. Methods We used Cox proportional hazards models, with age as the time scale, to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between ever use of individual pesticides and 883 cases of aggressive PCa (distant stage, poorly differentiated grade, Gleason score ≥ 7, or fatal prostate cancer) diagnosed between 1993 and 2015. All models adjusted for birth year, state, family history of PCa, race, and smoking status. We conducted exposure-response analyses for pesticides with reported lifetime years of use. Results There was an increased aggressive PCa risk among ever users of the organodithioate insecticide dimethoate (n = 54 exposed cases, HR = 1.37, 95% CI = 1.04, 1.80) compared to never users. We observed an inverse association between aggressive PCa and the herbicide triclopyr (n = 35 exposed cases, HR = 0.68, 95% CI = 0.48, 0.95), with the strongest inverse association for those reporting durations of use above the median (≥ 4 years; n = 13 exposed cases, HR=0.44, 95% CI=0.26, 0.77). Conclusion Few additional pesticides were associated with prostate cancer risk after evaluation of extended data from this large cohort of private pesticide applicators. |
| تدمد: | 1476-069X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84938b5359a3ce57b26081e1df50c066Test https://doi.org/10.1186/s12940-020-00583-0Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....84938b5359a3ce57b26081e1df50c066 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1476069X |
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