المؤلفون: James, Steven^1,2,3 (AUTHOR) Sjames1@usc.edu.au, Perry, Lin^4,5 (AUTHOR), Lowe, Julia⁶ (AUTHOR), Donaghue, Kim C.^7,8 (AUTHOR), Pham-Short, Anna⁷ (AUTHOR), Craig, Maria E.^7,8,9 (AUTHOR), the ADDN Study Group (AUTHOR), Ambler, Geoff (AUTHOR), Anderson, Kym (AUTHOR), Andrikopoulos, Sof (AUTHOR), Batch, Jenny (AUTHOR), Brown, Justin (AUTHOR), Cameron, Fergus (AUTHOR), Colman, Peter G. (AUTHOR), Conwell, Louise (AUTHOR), Cotterill, Andrew (AUTHOR), Couper, Jennifer (AUTHOR), Davis, Elizabeth (AUTHOR), de Bock, Martin (AUTHOR), Fairchild, Jan (AUTHOR)

المصدر: Acta Diabetologica. Nov2023, Vol. 60 Issue 11, p1471-1477. 7p.

مصطلحات موضوعية: *TYPE 1 diabetes, *YOUNG adults, *CELIAC disease, *GLYCOSYLATED hemoglobin, *COEXISTENCE of species, *DIABETES, *BODY mass index

مستخلص: Aim: To compare HbA1c and clinical outcomes in adolescents and young adults with type 1 diabetes (T1D), with or without celiac disease (CD). Methods: Longitudinal data were extracted from ADDN, a prospective clinical diabetes registry. Inclusion criteria were T1D (with or without CD), ≥ 1 HbA1c measurement, age 16–25 years and diabetes duration ≥ 1 year at last measurement. Multivariable Generalised Estimated Equation models were used for longitudinal analysis of variables associated with HbA1c. Results: Across all measurements, those with coexisting T1D and CD had lower HbA1c when compared to those with T1D alone (8.5 ± 1.5% (69.4 ± 16.8 mmol/mol) vs. 8.7 ± 1.8% (71.4 ± 19.8 mmol/mol); p < 0.001); lower HbA1c was associated with shorter diabetes duration (B = − 0.06; 95% CI − 0.07 to − 0.05; p < 0.001), male sex (B = − 0.24; − 0.36 to − 0.11; p < 0.001), insulin pump therapy use (B = − 0.46; − 0.58 to − 0.34; p < 0.001), coexistence of T1D and CD (B = − 0.28; − 0.48 to − 0.07; p = 0.01), blood pressure (B = − 0.16; − 0.23 to − 0.09; p < 0.001) and body mass index (B = -− 0.03; − 0.02 to − 0.04; p = 0.01) in the normal range. At last measurement, 11.7% of the total population had a HbA1c < 7.0% (53.0 mmol/mol). Conclusions: Across all measurements, coexisting T1D and CD is associated with lower HbA1c when compared to T1D alone. However, HbA1c is above target in both groups. [ABSTRACT FROM AUTHOR]

المؤلفون: Cardona-Hernandez, Roque, Dôvc, Klemen, Biester, Torben, Macedoni, Maddalena, Tauschmann, Martin, Mameli, Chiara, Ekhlaspour, Laya

مصطلحات موضوعية: Automated insulin delivery, Children, Technology, Time in range, Type 1 diabetes, Youths, Young Adult, Humans, Adolescent, Child, Adult, Diabetes Mellitus, Type 1, Hypoglycemic Agents, Glycemic Control, Blood Glucose Self-Monitoring, Blood Glucose, Insulin, Insulin Infusion Systems

الوصف: Type 1 diabetes (T1D) is the most frequent form of diabetes in pediatric age, affecting more than 1.5 million people younger than age 20 years worldwide. Early and intensive control of diabetes provides continued protection against both microvascular and macrovascular complications, enhances growth, and ensures normal pubertal development. In the absence of definitive reversal therapy for this disease, achieving and maintaining the recommended glycemic targets is crucial. In the last 30 years, enormous progress has been made using technology to better treat T1D. In spite of this progress, the majority of children, adolescents and young adults do not reach the recommended targets for glycemic control and assume a considerable burden each day. The development of promising new therapeutic advances, such as more physiologic insulin analogues, pioneering diabetes technology including continuous glucose monitoring and closed loop systems as well as new adjuvant drugs, anticipate a new paradigm in T1D management over the next few years. This review presents insights into current management of T1D in youths.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/7s31w37tTest

المؤلفون: Wright, Davene, Williams, Adrienne, Divers, Jasmin, Pihoker, Catherine, Liese, Angela, Bellatorre, Anna, Kahkoska, Anna, Bell, Ronny, Mendoza, Jason, Mayer-Davis, Elizabeth, Wisk, Lauren, Everett, Estelle

المصدر: Diabetes Technology and Therapeutics. 25(2)

مصطلحات موضوعية: Diabetes disparities, Insulin pump, Insurance coverage, Socioeconomic status, Type 1 diabetes, Humans, Adolescent, Young Adult, Adult, Diabetes Mellitus, Type 1, Cross-Sectional Studies, Ethnicity, Hispanic or Latino, Insulins, Healthcare Disparities

الوصف: Objective: To evaluate changes in insulin pump use over two decades in a national U.S. sample. Research Design and Methods: We used data from the SEARCH for Diabetes in Youth study to perform a serial cross-sectional analysis to evaluate changes in insulin pump use in participants

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/3fh8c384Test

المؤلفون: Mann, Elizabeth A, Rompicherla, Saketh, Gallagher, Mary Pat, Alonso, Guy Todd, Fogel, Naomi R, Simmons, Jill, Wood, Jamie R, Wong, Jenise C, Noor, Nudrat, Gomez, Patricia, Daniels, Mark, Ebekozien, Osagie

المصدر: Pediatric Diabetes. 23(7)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Clinical Sciences, Prevention, Clinical Research, Diabetes, Pediatric, 7.1 Individual care needs, Management of diseases and conditions, Metabolic and endocrine, Adolescent, COVID-19, Child, Comorbidity, Cross-Sectional Studies, Diabetes Mellitus, Type 1, Glycated Hemoglobin, Hospitalization, Humans, SARS-CoV-2, Young Adult, comorbidities, type 1 diabetes, Paediatrics and Reproductive Medicine, Endocrinology & Metabolism, Clinical sciences, Paediatrics

الوصف: ObjectivesWe evaluated COVID-19 outcomes in children and young adults with type 1 diabetes (T1D) to determine if those with comorbidities are more likely to experience severe COVID-19 compared to those without.Research design and methodsThis cross-sectional study included questionnaire data on patients

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/9b96d8j3Test

المؤلفون: Núñez-Baila, María-Ángeles, Gómez-Aragón, Anjhara, Marques-Silva, Armando-Manuel, González-López, José Rafael

المصدر: Healthcare (2227-9032); Feb2024, Vol. 12 Issue 3, p309, 21p

مصطلحات موضوعية: CINAHL database, MEDICAL databases, PSYCHOLOGY information storage & retrieval systems, ONLINE information services, TRANSITION to adulthood, TYPE 1 diabetes, HEALTH behavior, RESEARCH funding, MEDLINE, BEHAVIOR modification, HEALTH promotion

مستخلص: Emerging adulthood is a transitional stage with significant lifestyle changes, making it especially challenging for those living with type 1 diabetes mellitus. This systematic review synthesizes qualitative research to explore how emerging adulthood (18–29 years) influences lifestyle behaviors in individuals with type 1 diabetes mellitus. CINAHL, Cochrane Library, Global Health, Nursing & Allied Health Premium, PsycINFO, PubMed, Scopus, and WOS were searched for original qualitative studies addressing the lifestyle of 18–31-year-olds with type 1 diabetes mellitus, published between January 2010 and March 2021 following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Thirty-five studies met the inclusion criteria and their findings were categorized into eight topics (emotions and feelings, nutrition, perceptions, risky behaviors, self-care, sleep, social relationships, and stigma) using meta-aggregation, as outlined in the Joanna Briggs Institute Manual for Evidence Synthesis. The spontaneity characteristic of emerging adulthood can undermine self-care. This is because new environments, schedules, and relationships encountered during this life stage often lead to the neglect of diabetes management, owing to the various social, academic, and occupational demands. This review highlights the necessity of creating health promotion strategies tailored to the unique lifestyle aspects of emerging adults with type 1 diabetes mellitus. [ABSTRACT FROM AUTHOR]

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المؤلفون: Griggs, Stephanie¹ stephanie.griggs@case.edu, Hernandez, Estefania¹, Bolton, Pamela J.¹, Strohl, Kingman P.¹, Grey, Margaret², Kashyap, Sangeeta R.¹, Li, Chiang-shan R.³, Hickman Jr, Ronald L.¹

المصدر: Clinical Nursing Research. Mar2023, Vol. 32 Issue 3, p560-570. 11p.

مصطلحات موضوعية: *SELF-management (Psychology), *TYPE 1 diabetes, *SLEEP, *COGNITIVE therapy, *ADULTS

مستخلص: The purpose of this study was to explore perceptions of the first dose of a cognitive behavioral sleep self-management intervention (CB-sleep) among young adults aged 18 to 25 years with type 1 diabetes (T1D). We used a qualitative descriptive approach to conduct in-depth semi-structured focused interviews with a purposive sample of 16 young adults with T1D, transitioning from adolescence to early adulthood. Interviews were audio-recorded, transcribed verbatim, and analyzed using qualitative content analysis. Participants described their sleep knowledge (previous, new, and additional), sleep health goals, along with barriers and facilitators of the CB-sleep intervention. Based on these results, we suggest CB-sleep is a useful modality with the potential to support sleep self-management in young adults with T1D during this complex life transition. Furthermore, CB-sleep could be incorporated into an existing diabetes self-management education and support program after pilot testing and determining efficacy to improve sleep and glycemic health. [ABSTRACT FROM AUTHOR]

المؤلفون: Pinsker, Jordan, Dassau, Eyal, Deshpande, Sunil, Raghinaru, Dan, Buckingham, Bruce, Kudva, Yogish, Laffel, Lori, Levy, Carol, Church, Mei, Desrochers, Hannah, Ekhlaspour, Laya, Kaur, Ravinder, Levister, Camilla, Shi, Dawei, Lum, John, Kollman, Craig, Doyle, Francis

المصدر: Diabetes Technology and Therapeutics. 24(9)

مصطلحات موضوعية: Adaptation, Artificial pancreas, Automated insulin delivery, Glycemic control, Type 1 diabetes, Adult, Blood Glucose, Cross-Over Studies, Diabetes Mellitus, Type 1, Humans, Hypoglycemic Agents, Infant, Newborn, Insulin, Insulin Infusion Systems, Insulin, Regular, Human, Middle Aged, Outpatients, Young Adult

الوصف: Background: Automated insulin delivery (AID) systems have proven effective in increasing time-in-range during both clinical trials and real-world use. Further improvements in outcomes for single-hormone (insulin only) AID may be limited by suboptimal insulin delivery settings. Methods: Adults (≥18 years of age) with type 1 diabetes were randomized to either sensor-augmented pump (SAP) (inclusive of predictive low-glucose suspend) or adaptive zone model predictive control AID for 13 weeks, then crossed over to the other arm. Each week, the AID insulin delivery settings were sequentially and automatically updated by an adaptation system running on the study phone. Primary outcome was sensor glucose time-in-range 70-180 mg/dL, with noninferiority in percent time below 54 mg/dL as a hierarchical outcome. Results: Thirty-five participants completed the trial (mean age 39 ± 16 years, HbA1c at enrollment 6.9% ± 1.0%). Mean time-in-range 70-180 mg/dL was 66% with SAP versus 69% with AID (mean adjusted difference +2% [95% confidence interval: -1% to +6%], P = 0.22). Median time

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/76x9t6n0Test

المؤلفون: Obichi Onwukwe, Erika L. Lundgrin

المصدر: Frontiers in Clinical Diabetes and Healthcare, Vol 5 (2024)

مصطلحات موضوعية: adolescent, young adult, type 1 diabetes mellitus, glycated hemoglobin, self report, sociodemographic factors, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

الوصف: IntroductionAdolescents and young adults (AYA) living with type 1 diabetes (T1D) are a vulnerable demographic at risk for sub-optimal glycemic outcomes at a time when they are taking over their diabetes management. The purposes of this study were to examine levels of self-reported comfort with diabetes management tasks among AYA living with T1D and to describe the relationships among comfort levels, sociodemographic factors, and HbA1c. MethodsDuring a routine diabetes care visit, AYA aged 15–23 years old living with T1D received a transition survey to self-assess their comfort level with different diabetesmanagement tasks. ResultsAmong 161 participants who completed the survey (median age 17 years, median diabetes duration 7 years, 82.3% White, 40.9% female, 66.5% with private insurance, and median HbA1c 8.8%), comfort with diabetes management tasks was generally rated highly (median overall comfort level of 4.5 out of 5), irrespective of race or insurance type. Regression analysis revealed that higher self-reported comfort level with diabetes management tasks was associated with a higher HbA1c (p = 0.006), after controlling for age, sex, race, insurance type, and diabetes duration. DiscussionThese findings suggest that self-reported comfort with independently managing T1D may not be a sufficient metric in assessing AYA patients’ need for further intervention to optimize glycemic outcomes as they transition from pediatric to adult diabetes care, and highlights the importance of continuity of care to support diabetes management during this transitional period.

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fcdhc.2024.1304577/fullTest; https://doaj.org/toc/2673-6616Test

الوصول الحر: https://doaj.org/article/bfa949b68adf479387231b3ba14715e9Test

المؤلفون: Besançon, Stéphane, Govender, Denira, Sidibé, Assa Traore, Noble, Janelle Annette, Togo, Amagara, Lane, Julie Ann, Mack, Steven John, Atkinson, Mark A, Wasserfall, Clive Henry, Kakkat, Faizy, Martin, Gregory GN, Ogle, Graham David

المصدر: Pediatric Diabetes. 23(8)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Clinical Sciences, Diabetes, Autoimmune Disease, Pediatric, Clinical Research, Metabolic and endocrine, Adolescent, Adult, Child, Child, Preschool, Female, Humans, Infant, Male, Young Adult, Autoantibodies, C-Peptide, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Genetic Predisposition to Disease, Glutamate Decarboxylase, HLA-DRB1 Chains, Mali, autoantibody, childhood diabetes, C-peptide, HLA, Paediatrics and Reproductive Medicine, Endocrinology & Metabolism, Clinical sciences, Paediatrics

الوصف: ObjectiveLimited information is available regarding youth-onset diabetes in Mali. We investigated demographic, clinical, biochemical, and genetic features in new diabetes cases in children and adolescents.Research design and methodsThe study was conducted at Hôpital du Mali in Bamako. A total of 132 recently-diagnosed cases

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/2843g5wmTest

المؤلفون: Russell, Steven, Beck, Roy, Damiano, Edward, El-Khatib, Firas, Ruedy, Katrina, Balliro, Courtney, Li, Zoey, Calhoun, Peter, Wadwa, R, Buckingham, Bruce, Zhou, Keren, Daniels, Mark, Raskin, Philip, White, Perrin, Lynch, Jane, Pettus, Jeremy, Hirsch, Irl, Goland, Robin, Buse, John, Kruger, Davida, Mauras, Nelly, Muir, Andrew, McGill, Janet, Cogen, Fran, Weissberg-Benchell, Jill, Sherwood, Jordan, Castellanos, Luz, Hillard, Mallory, Tuffaha, Marwa, Putman, Melissa, Sands, Mollie, Forlenza, Gregory, Slover, Robert, Messer, Laurel, Cobry, Erin, Shah, Viral, Polsky, Sarit, Lal, Rayhan, Ekhlaspour, Laya, Hughes, Michael, Basina, Marina, Hatipoglu, Betul, Olansky, Leann, Bhangoo, Amrit, Forghani, Nikta, Kashmiri, Himala, Sutton, Francoise, Choudhary, Abha, Penn, Jimmy, Jafri, Rabab, Rayas, Maria, Escaname, Elia, Kerr, Catherine, Favela-Prezas, Ruby, Trikudanathan, Subbulaxmi, Williams, Kristen, Leibel, Natasha, Kirkman, M, Bergamo, Kate, Klein, Klara, Dostou, Jean, Machineni, Sriram, Young, Laura, Diner, Jamie, Bhan, Arti, Jones, J, Benson, Matthew, Bird, Keisha, Englert, Kimberly, Permuy, Joe, Cossen, Kristina, Felner, Eric, Salam, Maamoun, Silverstein, Julie, Adamson, Samantha, Cedeno, Andrea, Meighan, Seema, Dauber, Andrew, Boeder, Schafer

المصدر: The New England Journal of Medicine. 387(13)

مصطلحات موضوعية: Adolescent, Adult, Aged, Bionics, Blood Glucose, Blood Glucose Self-Monitoring, Child, Diabetes Mellitus, Type 1, Glycated Hemoglobin, Humans, Hypoglycemic Agents, Insulin, Insulin Aspart, Insulin Infusion Systems, Insulin Lispro, Middle Aged, Young Adult

الوصف: BACKGROUND: Currently available semiautomated insulin-delivery systems require individualized insulin regimens for the initialization of therapy and meal doses based on carbohydrate counting for routine operation. In contrast, the bionic pancreas is initialized only on the basis of body weight, makes all dose decisions and delivers insulin autonomously, and uses meal announcements without carbohydrate counting. METHODS: In this 13-week, multicenter, randomized trial, we randomly assigned in a 2:1 ratio persons at least 6 years of age with type 1 diabetes either to receive bionic pancreas treatment with insulin aspart or insulin lispro or to receive standard care (defined as any insulin-delivery method with unblinded, real-time continuous glucose monitoring). The primary outcome was the glycated hemoglobin level at 13 weeks. The key secondary outcome was the percentage of time that the glucose level as assessed by continuous glucose monitoring was below 54 mg per deciliter; the prespecified noninferiority limit for this outcome was 1 percentage point. Safety was also assessed. RESULTS: A total of 219 participants 6 to 79 years of age were assigned to the bionic-pancreas group, and 107 to the standard-care group. The glycated hemoglobin level decreased from 7.9% to 7.3% in the bionic-pancreas group and did not change (was at 7.7% at both time points) in the standard-care group (mean adjusted difference at 13 weeks, -0.5 percentage points; 95% confidence interval [CI], -0.6 to -0.3; P

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/1m5021wbTest