التفاصيل البيبلوغرافية
| العنوان: |
Effects of Nicotine Metabolic Rate on Withdrawal Symptoms and Response to Cigarette Smoking After Abstinence |
| المؤلفون: |
Liakoni, Evangelia, Edwards, Kathryn C, St. Helen, Gideon, Nardone, Natalie, Dempsey, Delia A, Tyndale, Rachel F, Benowitz, Neal L |
| المصدر: |
Clinical Pharmacology & Therapeutics, vol 105, iss 3 |
| بيانات النشر: |
eScholarship, University of California |
| سنة النشر: |
2019 |
| المجموعة: |
University of California: eScholarship |
| مصطلحات موضوعية: |
Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Tobacco Smoke and Health, Prevention, Substance Misuse, Clinical Research, Tobacco, Drug Abuse (NIDA only), Brain Disorders, Behavioral and Social Science, Good Health and Well Being, Adult, Cigarette Smoking, Female, Humans, Male, Middle Aged, Nicotine, Saliva, Smoking Cessation, Substance Withdrawal Syndrome, Tobacco Use Disorder, Young Adult, Pharmacology & Pharmacy |
| جغرافية الموضوع: |
641 - 651 |
| الوصف: |
This study investigated the influence of the rate of nicotine metabolism, as indicated by the nicotine metabolite ratio (NMR), on tobacco dependence. We stratified 136 smokers on the basis of saliva NMR as fast (n=65) and slow (n=71) metabolizers. Two "loading cigarettes" were smoked after overnight, and a "reward cigarette" was smoked after 6hours of daytime, abstinence. Blood nicotine concentrations, expired carbon monoxide, withdrawal/craving, and reward questionnaires were collected before/after smoking and during daytime abstinence. Compared with slow metabolizers, fast metabolizers had a shorter nicotine elimination half-life (P<0.001), lower plasma nicotine concentrations (P<0.001), and higher withdrawal/craving scores (P<0.05) for most times during daytime abstinence, indicating that fast metabolizers are likely smoking more to relieve withdrawal symptoms (negative reinforcement). Reward/satisfaction scores were similar in fast and slow metabolizers, suggesting that faster nicotine metabolism, assessed by NMR, is not associated with greater positive reinforcement. CYP2A6 normal (n=82) and reduced (n=42) genotype predicted plasma nicotine concentrations but not withdrawal symptoms. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
qt2nk7w7rh; https://escholarship.org/uc/item/2nk7w7rhTest |
| الإتاحة: |
https://escholarship.org/uc/item/2nk7w7rhTest |
| حقوق: |
CC-BY-NC-SA |
| رقم الانضمام: |
edsbas.C609077A |
| قاعدة البيانات: |
BASE |
