دورية أكاديمية
Genotoxicity surveillance programme in workers dismantling World War I chemical ammunition
| العنوان: | Genotoxicity surveillance programme in workers dismantling World War I chemical ammunition |
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| المؤلفون: | Mateuca, R. A., Carton, C., Roelants, M., Roesems, S., Lison, Dominique, Kirsch-Volders, M. |
| المساهمون: | UCL - SSS/IREC - Institut de recherche expérimentale et clinique |
| المصدر: | International Archives of Occupational and Environmental Health, Vol. 83, no. 5, p. 483-95 (2010) |
| بيانات النشر: | Springer |
| سنة النشر: | 2010 |
| المجموعة: | DIAL@UCL (Université catholique de Louvain) |
| مصطلحات موضوعية: | World War I, Sister Chromatid Exchange, Sentinel Surveillance, Protective Devices, Phosgene, Occupational Exposure, Mutagens, Micronuclei, Chromosome-Defective, Male, Lymphocytes, Hydrogen Cyanide, Humans, Health Behavior, Chromosome Aberrations, Chlorides, Chemical Warfare Agents, Arsenicals, Arsenic, Age Factors, Protective measures, Cytokinesis-block micronucleus assay, Sister chromatid exchanges, High frequency cells, Chromosomal aberrations |
| الوصف: | To evaluate the effectiveness of personal protective measures in a dismantling plant for chemical weapons from World War I of the Belgian Defence. Seventeen NIOSH level B-equipped plant workers exposed to arsenic trichloride (AsCl3) in combination with phosgene or hydrogen cyanide (HCN) were compared to 24 NIOSH level C-protected field workers occasionally exposed to genotoxic chemicals (including AsCl3-phosgene/HCN) when collecting chemical ammunition, and 19 matched referents. Chromosomal aberrations (CA), micronuclei (MNCB and MNMC), sister chromatid exchanges (SCE) and high frequency cells (HFC) were analysed in peripheral blood lymphocytes. Urinary arsenic levels and genetic polymorphisms in major DNA repair enzymes (hOGG1 (326) , XRCC1 (399) , XRCC3 (241) ) were also assessed. SCE and HFC levels were significantly higher in plant-exposed versus referent subjects, but MNCB and MNMC were not different. MNCB, SCE and HFC levels were significantly higher and MNMC levels significantly lower in field-exposed workers versus referents. AsCl3 exposure was not correlated with genotoxicity biomarkers. Protective measures for plant-exposed workers appear adequate, but protection for field-exposed individuals could be improved. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0340-0131 1432-1246 |
| العلاقة: | boreal:33869; http://hdl.handle.net/2078.1/33869Test; info:pmid/20306073; urn:ISSN:0340-0131; urn:EISSN:1432-1246 |
| DOI: | 10.1007/s00420-010-0526-2 |
| الإتاحة: | https://doi.org/10.1007/s00420-010-0526-2Test http://hdl.handle.net/2078.1/33869Test |
| حقوق: | info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.107D3762 |
| قاعدة البيانات: | BASE |
| تدمد: | 03400131 14321246 |
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| DOI: | 10.1007/s00420-010-0526-2 |