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1دورية أكاديمية
المؤلفون: Flanagan, Dustin J., Pentinmikko, Nalle, Luopajärvi, Kalle, Willis, Nicky J., Gilroy, Kathryn, Raven, Alexander P., Mcgarry, Lynn, Englund, Johanna I., Webb, Anna T., Scharaw, Sandra, Nasreddin, Nadia, Hodder, Michael C., Ridgway, Rachel A., Minnee, Emma, Sphyris, Nathalie, Gilchrist, Ella, Najumudeen, Arafath K., Romagnolo, Beatrice, Perret, Christine, Williams, Ann C., Clevers, Hans, Nummela, Pirjo, Lähde, Marianne, Alitalo, Kari, Hietakangas, Ville, Hedley, Ann, Clark, William, Nixon, Colin, Kirschner, Kristina, Jones, E. Yvonne, Ristimäki, Ari, Leedham, Simon J., Fish, Paul V., Vincent, Jean Paul, Katajisto, Pekka, Sansom, Owen J.
المساهمون: Institute of Biotechnology (-2009), University of Helsinki, CAN-PRO - Translational Cancer Medicine Program, Centre of Excellence in Stem Cell Metabolism, Helsinki Institute of Life Science HiLIFE, Institute of Biotechnology, Juha Klefström / Principal Investigator, Research Programs Unit, Department of Pathology, Doctoral Programme in Biomedicine, ATG - Applied Tumor Genomics, Doctoral Programme in Integrative Life Science, HUSLAB, Kari Alitalo / Principal Investigator, Molecular and Integrative Biosciences Research Programme, Biosciences, Nutrient sensing laboratory
مصطلحات موضوعية: STEM-CELLS, BETA-CATENIN, BONE-FORMATION, WNT, MUTATION, HOMEOSTASIS, ACTIVATION, INTESTINE, POLYPOSIS, PATHWAY, 1182 Biochemistry, cell and molecular biology, 3122 Cancers
وصف الملف: application/pdf
العلاقة: Acknowledgements We thank the Core Services and Advanced Technologies at the Cancer Research UK Beatson Institute (C596/A17196 and A31287), and particularly the Biological Services Unit, Histology Service and Molecular Technologies; members of the Sansom and Katajisto laboratories for discussions of the data and manuscript; and BRC Oxford for supplying patient material. O.J.S. and his laboratory members were supported by Cancer Research UK (A28223, A21139, A12481 and A17196). D.J.F. and M.C.H. were supported by the UK Medical Research Council (MR/R017247/1 and MR/J50032X/1, respectively). SpecifiCancer CRUK Grand Challenge (C7932/A29055) is funded by Cancer Research UK and the Mark Foundation for Cancer Research. P.K. and his laboratory members were supported by the Academy of Finland Centre of Excellence MetaStem (266869, 304591 and 320185), the ERC Starting Grant 677809, the Swedish Research Council 2018-03078, the Cancerfonden 190634, the Jane and Aatos Erkko Foundation and the Cancer Foundation Finland. N.P. was supported by the Finnish Cultural Foundation, the Biomedicum Helsinki Foundation, the Orion Research Foundation sr and The Paulo Foundation. P.V.F. was supported by Alzheimer’s Research UK and The Francis Crick Institute. The ARUK UCL Drug Discovery Institute receives its core funding from Alzheimer’s Research UK (520909). The Francis Crick Institute receives its core funding from Cancer Research UK (FC001002), the UK Medical Research Council (FC001002) and the Wellcome Trust (FC001002).; Flanagan , D J , Pentinmikko , N , Luopajärvi , K , Willis , N J , Gilroy , K , Raven , A P , Mcgarry , L , Englund , J I , Webb , A T , Scharaw , S , Nasreddin , N , Hodder , M C , Ridgway , R A , Minnee , E , Sphyris , N , Gilchrist , E , Najumudeen , A K , Romagnolo , B , Perret , C , Williams , A C , Clevers , H , Nummela , P , Lähde , M , Alitalo , K , Hietakangas , V , Hedley , A , Clark , W , Nixon , C , Kirschner , K , Jones , E Y , Ristimäki , A , Leedham , S J , Fish , P V , Vincent , J P , Katajisto , P & Sansom , O J 2021 , ' NOTUM from Apc-mutant cells biases clonal competition to initiate cancer ' , Nature , vol. 594 , no. 7863 , pp. 430-435 . https://doi.org/10.1038/s41586-021-03525-zTest , https://doi.org/10.1038/s41586-021-03525-zTest; ORCID: /0000-0001-9637-6843/work/97056080; ORCID: /0000-0002-3764-5721/work/124844611; ORCID: /0000-0002-2768-8816/work/125976777; 85107302159; 0d60f233-972d-476c-b6db-817ae967b4bb; http://hdl.handle.net/10138/337493Test; 000657239300001
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2دورية أكاديمية
المؤلفون: Diamantopoulou, Zoi, White, Gavin, Fadlullah Wilmot, Muhammad, Dreger, Marcel, Pickering, Karen, Maltas, Joe, Ashton, Garry, MacLeod, Ruth, Baillie, George S., Kouskoff, Valerie, Lacaud, Georges, Murray, Graeme I., Sansom, Owen J., Hurlstone, Adam, Malliri, Angeliki
المصدر: Diamantopoulou , Z , White , G , Fadlullah Wilmot , M , Dreger , M , Pickering , K , Maltas , J , Ashton , G , MacLeod , R , Baillie , G S , Kouskoff , V , Lacaud , G , Murray , G I , Sansom , O J , Hurlstone , A & Malliri , A 2017 , ' TIAM1 antagonizes TAZ/YAP both in the destruction complex in the cytoplasm and in the nucleus to inhibit invasion of intestinal epithelial cells ' , Cancer Cell , vol. 31 , no. 5 , ....
مصطلحات موضوعية: TIAM1, TAZ, YAP, WNT, intestinal tumorigenesis, colorectal cancer, ResearchInstitutes_Networks_Beacons/mcrc, Manchester Cancer Research Centre
الإتاحة: https://doi.org/10.1016Test/j.ccell.2017.03.007
https://research.manchester.ac.uk/en/publications/92e17985-b044-45aa-8d74-796f6253f1c3Test -
3دورية أكاديمية
المؤلفون: Myant, Kevin, Sansom, Owen J. o.sansom@beatson.gla.ac.uk
المصدر: Experimental Cell Research. Nov2011, Vol. 317 Issue 19, p2725-2731. 7p.
مصطلحات موضوعية: *COLON cancer, *TRANSCRIPTION factors, *HOMEOSTASIS, *PROTEIN-protein interactions, *CARCINOGENESIS, *WNT proteins, *MYC proteins
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4دورية أكاديمية
المؤلفون: Sansom, Owen J.1,2, Griffiths, David F. R.3, Reed, Karen R.1, Winton, Douglas J.4, Clarke, Alan R.1 clarkear@cf.ac.uk
المصدر: Oncogene. 12/8/2005, Vol. 24 Issue 55, p8205-8210. 6p. 3 Diagrams.
مصطلحات موضوعية: *RENAL cancer, *RENAL cell carcinoma, *CANCER genetics, *ONCOLOGY, *GENETICS, *DIAGNOSIS
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5دورية أكاديمية
المؤلفون: Sphyris, Nathalie, Hodder, Michael C., Sansom, Owen J., Allegrucci, Cinzia, Ordóñez-Morán, Paloma
المصدر: Cancers; Mar2021, Vol. 13 Issue 5, p1000-1000, 1p
مصطلحات موضوعية: COLON tumors, RECTUM tumors, INFLAMMATION, REGENERATION (Biology), NEOPLASTIC cell transformation, CELLULAR signal transduction, EPITHELIUM, STEM cells, INTESTINES
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6دورية أكاديمية
المؤلفون: Flanagan, Dustin J.1,2 (AUTHOR), Woodcock, Simon A.3 (AUTHOR), Phillips, Caroline3 (AUTHOR), Eagle, Catherine3 (AUTHOR), Sansom, Owen J.1,4 (AUTHOR) o.sansom@beatson.gla.ac.uk
المصدر: Pharmacology & Therapeutics. Oct2022, Vol. 238, pN.PAG-N.PAG. 1p.
مصطلحات موضوعية: *GASTROINTESTINAL cancer, *PORCUPINES, *CLINICAL trials
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7دورية أكاديميةOpposing effects of TIGAR- and RAC1- derived ROS on Wnt-driven proliferation in the mouse intestine.
المؤلفون: Cheung, Eric C.1, Lee, Pearl1, Ceteci, Fatih1, Nixon, Colin1, Blyth, Karen1, Sansom, Owen J.1, Vousden, Karen H.1 k.vousden@beatson.gla.ac.uk
المصدر: Genes & Development. Jan2016, Vol. 30 Issue 1, p52-63. 12p.
مصطلحات موضوعية: *REACTIVE oxygen species, *WNT genes, *APOPTOSIS, *DNA damage, *CANCER treatment, *LABORATORY mice
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8دورية أكاديمية
المؤلفون: Rajan, Prabhakar1,2 p.rajan@beatson.gla.ac.uk, Sudbery, Ian M.3, Villasevil, M. Eugenia M.1,2, Mui, Ernest2, Fleming, Janis2, Davis, Mark4, Ahmad, Imran1,2, Edwards, Joanne1, Sansom, Owen J.2, Sims, David3, Ponting, Chris P.3, Heger, Andreas3, McMenemin, Rhona M.5, Pedley, Ian D.5, Leung, Hing Y.1,2 h.leung@beatson.gla.ac.uk
المصدر: European Urology. Jul2014, Vol. 66 Issue 1, p32-39. 8p.
مصطلحات موضوعية: *PROSTATE cancer treatment, *ANDROGEN drugs, *PROSTATE cancer patients, *HORMONE resistance, *PROSTATE cancer prognosis, *CANCER invasiveness, *RNA sequencing, *IN vitro studies
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9دورية أكاديمية
المؤلفون: Subauste, M. Cecilia1, Ventura-Holman, Tereza2, Lu, Deyin2, Du, Liqin1, Sansom, Owen J.3, Maher, Joseph F.1 joseph.maher@utsouthwestern.edu
المصدر: Cancer Epidemiology. Feb2011, Vol. 35 Issue 1, p97-100. 4p.
مصطلحات موضوعية: *ANTIGENS, *LABORATORY mice, *BIOMARKERS, *WNT genes, *INTESTINAL tumors, *COLON cancer, *TUMOR suppressor genes, *EPITOPES