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1دورية أكاديمية
المؤلفون: Lixue Lu, Yafei Huang, Meiqi Song, Nannan Sun, Li Xia, Mingcheng Yu, Meiling Zhao, Ruomeng Qiu, Ji-an Chen, Yunpeng Zhao, Haojie Wang, Huimin Guo, Yan Li, Di Zhu, Yonghui Wang, Qiong Xie
مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Immunology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, sup >+ sup, preclinical tumor models, mouse b16f10 melanoma, llc lung adenocarcinoma, demonstrated robust efficacy, current studies indicate, biaryl amide derivatives, rorγt agonists provide, novel rorγt agonists, 14 b, vivo <, taken together, reachable approach, pharmacokinetic profiles, cancer immunotherapy
الإتاحة: https://doi.org/10.1021/acs.jmedchem.3c01492.s001Test
https://figshare.com/articles/journal_contribution/Discovery_of_Biaryl_Amide_Derivatives_as_Potent_Selective_and_Orally_Bioavailable_ROR_t_Agonists_for_Cancer_Immunotherapy/24591888Test -
2دورية أكاديمية
المؤلفون: Ji-An Chen (9305742), Hui Ma (290168), Zehui Liu (4023659), Jinlong Tian (5878574), Sisi Lu (6916592), Wenqing Fang (11879351), Shuyin Ze (11879354), Weiqiang Lu (165510), Qiong Xie (709001), Jin Huang (146235), Yonghui Wang (287491)
مصطلحات موضوعية: Biochemistry, Cell Biology, Pharmacology, Biotechnology, Immunology, Cancer, Space Science, Chemical Sciences not elsewhere classified, present study provides, multifactorial autoimmune disease, major clinical challenge, dextran sulfate sodium, may enhance anti, 50 sub, 14d b, potent dual rorγt, vivo <, therapeutic agents, taken together, reduce rorγt, novel framework, inflammatory effects, inflammatory activity, exhibited remarkable, dual rorγt, dihydroorotate dehydrogenase, dependently alleviated, aminobenzothiazole hit, 297 μm, 110 μm
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3
المؤلفون: Lixue Lu, Yafei Huang, Meiqi Song, Nannan Sun, Li Xia, Mingcheng Yu, Meiling Zhao, Ruomeng Qiu, Ji-an Chen, Yunpeng Zhao, Haojie Wang, Huimin Guo, Yan Li, Di Zhu, Yonghui Wang, Qiong Xie
مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Immunology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, sup >+ sup, preclinical tumor models, mouse b16f10 melanoma, llc lung adenocarcinoma, demonstrated robust efficacy, current studies indicate, biaryl amide derivatives, rorγt agonists provide, novel rorγt agonists, 14 b, vivo <, taken together, reachable approach, pharmacokinetic profiles, cancer immunotherapy
الإتاحة: https://doi.org/10.1021/acs.jmedchem.3c01492.s003Test
https://figshare.com/articles/dataset/Discovery_of_Biaryl_Amide_Derivatives_as_Potent_Selective_and_Orally_Bioavailable_ROR_t_Agonists_for_Cancer_Immunotherapy/24591894Test -
4
المؤلفون: Lixue Lu, Yafei Huang, Meiqi Song, Nannan Sun, Li Xia, Mingcheng Yu, Meiling Zhao, Ruomeng Qiu, Ji-an Chen, Yunpeng Zhao, Haojie Wang, Huimin Guo, Yan Li, Di Zhu, Yonghui Wang, Qiong Xie
مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Immunology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, sup >+ sup, preclinical tumor models, mouse b16f10 melanoma, llc lung adenocarcinoma, demonstrated robust efficacy, current studies indicate, biaryl amide derivatives, rorγt agonists provide, novel rorγt agonists, 14 b, vivo <, taken together, reachable approach, pharmacokinetic profiles, cancer immunotherapy
الإتاحة: https://doi.org/10.1021/acs.jmedchem.3c01492.s004Test
https://figshare.com/articles/dataset/Discovery_of_Biaryl_Amide_Derivatives_as_Potent_Selective_and_Orally_Bioavailable_ROR_t_Agonists_for_Cancer_Immunotherapy/24591897Test -
5
المؤلفون: Lixue Lu, Yafei Huang, Meiqi Song, Nannan Sun, Li Xia, Mingcheng Yu, Meiling Zhao, Ruomeng Qiu, Ji-an Chen, Yunpeng Zhao, Haojie Wang, Huimin Guo, Yan Li, Di Zhu, Yonghui Wang, Qiong Xie
مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Immunology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, sup >+ sup, preclinical tumor models, mouse b16f10 melanoma, llc lung adenocarcinoma, demonstrated robust efficacy, current studies indicate, biaryl amide derivatives, rorγt agonists provide, novel rorγt agonists, 14 b, vivo <, taken together, reachable approach, pharmacokinetic profiles, cancer immunotherapy
الإتاحة: https://doi.org/10.1021/acs.jmedchem.3c01492.s002Test
https://figshare.com/articles/dataset/Discovery_of_Biaryl_Amide_Derivatives_as_Potent_Selective_and_Orally_Bioavailable_ROR_t_Agonists_for_Cancer_Immunotherapy/24591891Test -
6
المؤلفون: Lixue Lu, Yafei Huang, Meiqi Song, Nannan Sun, Li Xia, Mingcheng Yu, Meiling Zhao, Ruomeng Qiu, Ji-an Chen, Yunpeng Zhao, Haojie Wang, Huimin Guo, Yan Li, Di Zhu, Yonghui Wang, Qiong Xie
مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Immunology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, sup >+ sup, preclinical tumor models, mouse b16f10 melanoma, llc lung adenocarcinoma, demonstrated robust efficacy, current studies indicate, biaryl amide derivatives, rorγt agonists provide, novel rorγt agonists, 14 b, vivo <, taken together, reachable approach, pharmacokinetic profiles, cancer immunotherapy
الإتاحة: https://doi.org/10.1021/acs.jmedchem.3c01492.s005Test
https://figshare.com/articles/dataset/Discovery_of_Biaryl_Amide_Derivatives_as_Potent_Selective_and_Orally_Bioavailable_ROR_t_Agonists_for_Cancer_Immunotherapy/24591900Test -
7
المؤلفون: Lixue Lu, Yafei Huang, Meiqi Song, Nannan Sun, Li Xia, Mingcheng Yu, Meiling Zhao, Ruomeng Qiu, Ji-an Chen, Yunpeng Zhao, Haojie Wang, Huimin Guo, Yan Li, Di Zhu, Yonghui Wang, Qiong Xie
مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Immunology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, sup >+ sup, preclinical tumor models, mouse b16f10 melanoma, llc lung adenocarcinoma, demonstrated robust efficacy, current studies indicate, biaryl amide derivatives, rorγt agonists provide, novel rorγt agonists, 14 b, vivo <, taken together, reachable approach, pharmacokinetic profiles, cancer immunotherapy
الإتاحة: https://doi.org/10.1021/acs.jmedchem.3c01492.s006Test
https://figshare.com/articles/dataset/Discovery_of_Biaryl_Amide_Derivatives_as_Potent_Selective_and_Orally_Bioavailable_ROR_t_Agonists_for_Cancer_Immunotherapy/24591903Test -
8
المؤلفون: Lixue Lu, Yafei Huang, Meiqi Song, Nannan Sun, Li Xia, Mingcheng Yu, Meiling Zhao, Ruomeng Qiu, Ji-an Chen, Yunpeng Zhao, Haojie Wang, Huimin Guo, Yan Li, Di Zhu, Yonghui Wang, Qiong Xie
مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Immunology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, sup >+ sup, preclinical tumor models, mouse b16f10 melanoma, llc lung adenocarcinoma, demonstrated robust efficacy, current studies indicate, biaryl amide derivatives, rorγt agonists provide, novel rorγt agonists, 14 b, vivo <, taken together, reachable approach, pharmacokinetic profiles, cancer immunotherapy
الإتاحة: https://doi.org/10.1021/acs.jmedchem.3c01492.s007Test
https://figshare.com/articles/dataset/Discovery_of_Biaryl_Amide_Derivatives_as_Potent_Selective_and_Orally_Bioavailable_ROR_t_Agonists_for_Cancer_Immunotherapy/24591909Test -
9
المؤلفون: Ji-An Chen (9305742), Hui Ma (290168), Zehui Liu (4023659), Jinlong Tian (5878574), Sisi Lu (6916592), Wenqing Fang (11879351), Shuyin Ze (11879354), Weiqiang Lu (165510), Qiong Xie (709001), Jin Huang (146235), Yonghui Wang (287491)
مصطلحات موضوعية: Biochemistry, Cell Biology, Pharmacology, Biotechnology, Immunology, Cancer, Space Science, Chemical Sciences not elsewhere classified, present study provides, multifactorial autoimmune disease, major clinical challenge, dextran sulfate sodium, may enhance anti, 50 sub, 14d b, potent dual rorγt, vivo <, therapeutic agents, taken together, reduce rorγt, novel framework, inflammatory effects, inflammatory activity, exhibited remarkable, dual rorγt, dihydroorotate dehydrogenase, dependently alleviated, aminobenzothiazole hit, 297 μm, 110 μm
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10صورة
المؤلفون: Steven A. Saenz (11668881), Andrea Local (11668884), Tiffany Carr (11668887), Arvind Shakya (120984), Shivsmriti Koul (11668890), Haiqing Hu (96108), Lisa Chourb (11668893), Justin Stedman (11668896), Jenna Malley (10811582), Laura Akullian D’Agostino (8633694), Veerabahu Shanmugasundaram (294662), John Malona (11668899), C. Eric Schwartz (1944748), Lisa Beebe (11668902), Meghan Clements (11668905), Ganesh Rajaraman (3940082), John Cho (11668908), Lan Jiang (57811), Alex Dubrovskiy (8633670), Matt Kreilein (11668911), Roman Shimanovich (1637992), Lawrence G. Hamann (1436563), Laure Escoubet (11668914), J. Michael Ellis (1648321)
مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Immunology, Cancer, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, retinoic acid receptor, pancreatic ductal adenocarcinoma, div >< p, attractive therapeutic target, associated gene expression, numerous autoimmune diseases, delay tumor volume, inhibit th17 differentiation, inhibit tumor formation, rorγt block th17, tumor formation, autoimmune disorders, tumor growth, tumor effects, th17 cells, vivo <, vitro <, transcription factors, rorγt inhibitors, rorγt functions