التفاصيل البيبلوغرافية
| العنوان: |
Long-term (4 years) results of choroidal hemangioma treated with proton beam irradiation. |
| المؤلفون: |
Zeisberg, A., Seibel, I., Cordini, D., Lakotka, N., Willerding, G., Moser, L., Heufelder, J., Joussen, A. M. |
| المصدر: |
Graefe's Archive of Clinical & Experimental Ophthalmology; Jul2014, Vol. 252 Issue 7, p1165-1170, 6p |
| مصطلحات موضوعية: |
CHOROID, HEMANGIOMAS, PROTON therapy, PHOTODYNAMIC therapy, VISUAL acuity, FOLLOW-up studies (Medicine), OPHTHALMOLOGY, TUMORS, THERAPEUTICS |
| مستخلص: |
Background: The aim of this retrospective study was to determine the efficacy of proton beam irradiation in choroidal hemangioma in a long-term follow-up. Patients and methods: A total dose of 20 Cobalt Gray equivalent (CGE) was administered to 50 eyes of 50 patients from September 1998 to September 2010. All treated patients presented with a symptomatic tumor. Nine patients were pre-treated by photodynamic therapy (PDT). Visual outcome, tumor regression, and complications resulting from radiation were investigated. Results: The mean follow-up was 55.4 months (range 13-132). Tumor thickness decreased in all patients. Retinal re-attachment was achieved without evidence of tumor leakage. Visual acuity improved by two lines after one year in 43.4 % of patients and after two years in 36.8 % of patients. During the 55.4 months of long-term follow-up the visual acuity improved from 6/15 to 6/12 after proton therapy. Twenty-three patients (46.0 %) developed radiation retinopathy. According to the Finger classification of 2004, 21 patients (42.0 %) showed a stage 1 or 2 (functionally not relevant) retinopathy, and two patients (4.0 %) presented a stage 3 or 4 (functionally relevant) retinopathy. Further complications included sicca syndrome in nine cases, cataract formation in 10 cases, and radiation optic neuropathy in four cases. Conclusion: Proton therapy with 20 CGE is an efficient primary therapy in choroidal hemangioma and is very effective as a secondary treatment after PDT. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
