المؤلفون: Murrow, Lyndsay, Debnath, Jayanta

المصدر: Autophagy. 11(6)

مصطلحات موضوعية: Biochemistry and Cell Biology, Biological Sciences, 1.1 Normal biological development and functioning, Underpinning research, Aetiology, 2.1 Biological and endogenous factors, Amino Acid Sequence, Animals, Autophagy, Endosomes, Humans, Microtubule-Associated Proteins, Small Ubiquitin-Related Modifier Proteins, Ubiquitin-Conjugating Enzymes, ATG3, ATG12, basal autophagy, exosome, late endosome, PDCD6IP, Alix, viral budding, PDCD6IP/Alix, Biochemistry & Molecular Biology, Biochemistry and cell biology

الوصف: In addition to supporting cell survival in response to starvation or stress, autophagy promotes basal protein and organelle turnover. Compared to our understanding of stress-induced autophagy, little is known about how basal autophagy is regulated and how its activity is coordinated with other cellular processes. We recently identified a novel interaction between the ATG12-ATG3 conjugate and the ESCRT-associated protein PDCD6IP/Alix that promotes basal autophagy and endolysosomal trafficking. Moreover, ATG12-ATG3 is required for diverse PDCD6IP-mediated functions including late endosome distribution, exosome secretion, and viral budding. Our results highlight the importance of late endosomes for basal autophagic flux and reveal distinct roles for the core autophagy proteins ATG12 and ATG3 in controlling late endosome function.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/5874s94dTest

المؤلفون: Jayanta Debnath, Lyndsay M. Murrow

المصدر: Autophagy, vol 11, iss 6

مصطلحات موضوعية: late endosome, Biochemistry & Molecular Biology, Endosome, ATG12, 1.1 Normal biological development and functioning, Viral budding, Endosomes, Biology, Exosome, Autophagic Puncta, PDCD6IP/Alix, Underpinning research, Organelle, Autophagy, exosome, 2.1 Biological and endogenous factors, Animals, Humans, Secretion, viral budding, Amino Acid Sequence, Aetiology, Molecular Biology, Late endosome, PDCD6IP, Cell Biology, Cell biology, Alix, Ubiquitin-Conjugating Enzymes, Small Ubiquitin-Related Modifier Proteins, ATG3, Biochemistry and Cell Biology, Microtubule-Associated Proteins, basal autophagy

الوصف: In addition to supporting cell survival in response to starvation or stress, autophagy promotes basal protein and organelle turnover. Compared to our understanding of stress-induced autophagy, little is known about how basal autophagy is regulated and how its activity is coordinated with other cellular processes. We recently identified a novel interaction between the ATG12-ATG3 conjugate and the ESCRT-associated protein PDCD6IP/Alix that promotes basal autophagy and endolysosomal trafficking. Moreover, ATG12-ATG3 is required for diverse PDCD6IP-mediated functions including late endosome distribution, exosome secretion, and viral budding. Our results highlight the importance of late endosomes for basal autophagic flux and reveal distinct roles for the core autophagy proteins ATG12 and ATG3 in controlling late endosome function.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::638170873b8855f2c3815ec1bfee6af1Test
https://doi.org/10.1080/15548627.2015.1040976Test