التفاصيل البيبلوغرافية
| العنوان: |
Membrane estrogen receptor alpha (ERα) participates in flow- mediated dilation in a ligand- independent manner. |
| المؤلفون: |
Favre, Julie1, Vessieres, Emilie1,2, Guihot, Anne- Laure1,2, Proux, Coralyne1,2, Grimaud, Linda1, Rivron, Jordan1,2, Garcia, Manuela CL1,2, Réthoré, Léa1, Zahreddine, Rana3, Davezac, Morgane3, Fébrissy, Chanaelle3, Adlanmerini, Marine3, Loufrani, Laurent1,4, Procaccio, Vincent1,4, Foidart, Jean- Michel5, Flouriot, Gilles6, Lenfant, Françoise3, Fontaine, Coralie3, Arnal, Jean- François3, Henrion, Daniel1,2,4 daniel.henrion@univ-angers.fr |
| المصدر: |
eLife. 12/16/2021, p1-28. 28p. |
| مصطلحات موضوعية: |
*ESTROGEN receptors, *VASCULAR resistance, *OXIDATIVE stress, *ATHEROSCLEROTIC plaque, *ACETYLCHOLINE |
| مستخلص: |
Estrogen receptor alpha (ERα) activation by estrogens prevents atheroma through its nuclear action, whereas plasma membrane- located ERα accelerates endothelial healing. The genetic deficiency of ERα was associated with a reduction in flow- mediated dilation (FMD) in one man. Here, we evaluated ex vivo the role of ERα on FMD of resistance arteries. FMD, but not agonist (acetylcholine, insulin)- mediated dilation, was reduced in male and female mice lacking ERα (Esr1-/- mice) compared to wild- type mice and was not dependent on the presence of estrogens. In C451A- ERα mice lacking membrane ERα, not in mice lacking AF2- dependent nuclear ERα actions, FMD was reduced, and restored by antioxidant treatments. Compared to wild- type mice, isolated perfused kidneys of C451A- ERα mice revealed a decreased flow- mediated nitrate production and an increased H2O2 production. Thus, endothelial membrane ERα promotes NO bioavailability through inhibition of oxidative stress and thereby participates in FMD in a ligand- independent manne [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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