التفاصيل البيبلوغرافية
| العنوان: |
Endothelin-1, vascular endothelial growth factor and systolic pulmonary artery pressure in patients with Chuvash polycythemia |
| المؤلفون: |
Bushuev, Vladimir I., Miasnikova, Galina Y., Sergueeva, Adelina I., Polyakova, Lydia A., Okhotin, Daniel, Gaskin, Peter R., Debebe, Zufan, Nekhai, Sergei, Castro, Oswaldo L., Prchal, Josef T., Gordeuk, Victor R. |
| المصدر: |
The Center For Sickle Cell Disease Faculty Publications |
| بيانات النشر: |
Digital Howard @ Howard University |
| سنة النشر: |
2006 |
| المجموعة: |
Howard University: Digital Howard |
| مصطلحات موضوعية: |
Chuvash polycythemia, Endothelin-1, Pulmonary embolism, Vascular endothelial growth factor, VEGF |
| الوصف: |
Background and Objectives. Endothelin-1 has been associated with development of hypoxia-related pulmonary hypertension and vascular endothelial growth factor (VEGF) with protection from this complication. In Chuvash polycythemia, homozygous germline von Hippel-Lindau (VHL) 598C→T leads to up-regulation during normoxia of hypoxia inducible factor-1α and several hypoxia-controlled genes including erythropoietin and VEGF. We postulated that endothelin-1 and pulmonary artery pressure may be elevated in Chuvash polycythemia. Design and Methods. Systolic pulmonary artery blood pressure was estimated by Doppler echocardiography and plasma concentrations of endothelin-1, VEGF and erythropoietin were determined in 14 patients with Chuvash polycythemia and 14 controls. Results. Plasma endothelin-1 (p=0.010), VEGF (p=0.022) and erythropoietin (p<0.0005) concentrations and Doppler-estimated systolic pulmonary artery pressures (p<0.0005) were higher in the patients while systolic systemic blood pressures were lower (P=0.001). Five (36%) patients and no controls had mild pulmonary hypertension defined as systolic pulmonary artery pressure ≥35 mmHg. Among the patients with Chuvash polycythemia, the trends of association of estimated pulmonary artery pressure with plasma concentrations of endothelin-1 (R = +0.236), VEGF (R = -0.389) and erythropoietin (R = +0.220) were not statistically significant. Interpretations and Conclusions. Estimated systolic pulmonary artery pressure and plasma concentrations of endothelin-1 and VEGF are increased in patients with Chuvash polycythemia patients. The lack of significant associations of estimated systolic pulmonary artery pressure with plasma endothelin-1 and VEGF levels could conceivably be due to the small sample size. Further studies are indicated, especially in view of the reported efficacy of endothelin-1 receptor blockers in treating hypoxia-associated pulmonary hypertension. ©2006 Ferrata Storti Foundation. |
| نوع الوثيقة: |
text |
| اللغة: |
unknown |
| العلاقة: |
https://dh.howard.edu/sicklecell_fac/176Test |
| الإتاحة: |
https://dh.howard.edu/sicklecell_fac/176Test |
| رقم الانضمام: |
edsbas.6A25C07A |
| قاعدة البيانات: |
BASE |
