التفاصيل البيبلوغرافية
| العنوان: |
Effect and rational application of topical photodynamic therapy (PDT) with 5-aminolevulinic acid (5-ALA) for treatment of cervical intraepithelial neoplasia with vaginal intraepithelial neoplasia. |
| المؤلفون: |
SU, Yuehui, Zhang, Yingcui, Tong, Yutong, Zhang, Luoman, Li, Panpan, Zhang, Huiping, Zhang, Xiaodong, Tang, Yujie, Qin, Lihong, Shen, Yan, Wang, Bingjie, Zhou, Yingying, Cao, Lili, Zhang, Mengzhen, Zhang, Ting |
| المصدر: |
Photodiagnosis & Photodynamic Therapy; Mar2022, Vol. 37, pN.PAG-N.PAG, 1p |
| مستخلص: |
Lesions in both the cervix and vagina require an efficacious non-invasive treatment therapy such as 5-Aminolevulinic acid photodynamic therapy(5-ALA-PDT). In this study, we evaluate clinical efficacy and safety of 5-ALA PDT for cervical intraepithelial neoplasia with vaginal intraepithelial neoplasia (CIN & VAIN). A retrospective analysis was performed on 48 patients diagnosed with CIN & VAIN and receiving 5-ALA PDT. All patients were first followed up at 3, 6 and 12 months after treatment, then every 6 months thereafter. Out of 1051 patients referred for CIN (4.56%), 48 were diagnosed with CIN&VAIIN. The patients had statistically significant average vaginal and cervical lesion areas of 1.22 and 0.41 cm2 respectively. 4 patients were lost during follow-up. The patients' complete remission (CR) rate was 88.64% (39/44) at 3–6 months after treatment, while the total HPV clearance rate was 46.34 and 60.98% at 3- and 12-months follow-up,respectively. HPV16/18 combined with other high-risk human papillomaviruses (hrHPV) (HPV16/18 and other hrHPV) infection exhibited a lower HPV clearance rate (P = 0.006). The treatment time in high-grade intraepithelial neoplasia (HSIL) was higher than that of low-grade intraepithelial neoplasia (LSIL). Notably, atypical vessels and endocervical canal lesions involvement significantly affected 5-ALA PDT. Moreover, 5 patients had residual lesions (11.36%) during follow-up, one patient presented recurrence (2.56%), while 4 had successful pregnancy. 5-ALA-PDT is a non-invasive, effective, and safe therapy for treating CIN & VAIN and can maintain the structural and functional integrity of target organs. However, its efficacy is relatively poor in patients with endocervical canal lesions involvement, atypical vessels, and HPV16/18 and other hrHPV infection. • 5-Aminolevulinic acid (5-ALA) photodynamic therapy(PDT) can simultaneously treat cervical intraepithelial neoplasia (CIN) and vaginal intraepithelial neoplasia(VAIN). • 5-Aminolevulinic acid (5-ALA) photodynamic therapy(PDT) has no serious adverse reactions and can maintain the structural and functional integrity of the target organ. It is a good choice especially for patients with fertility requirements. • 5-Aminolevulinic acid (5-ALA) photodynamic therapy(PDT) had a long-term effect on HPV clearance. • For patients with endocervical canal lesions involvement or atypical blood vessels, the effect of 5-Aminolevulinic acid (5-ALA) photodynamic therapy(PDT) was relatively poor. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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