المؤلفون: Rissanen, Ilona, Krumm, Stefanie A., Stass, Robert, Whitaker, Annalis, Voss, James E., Bruce, Emily A., Rothenberger, Sylvia, Kunz, Stefan, Burton, Dennis R., Huiskonen, Juha T., Botten, Jason W., Bowden, Thomas A., Doores, Katie J.

المساهمون: Institute of Biotechnology, Molecular and Integrative Biosciences Research Programme, Helsinki Institute of Life Science HiLIFE

مصطلحات موضوعية: glycoprotein, hantavirus, neutralizing antibody, structure, zoonosis, HANTAVIRUS PULMONARY SYNDROME, HEMORRHAGIC-FEVER, PUUMALA VIRUS, NEPHROPATHIA-EPIDEMICA, MONOCLONAL-ANTIBODIES, NUCLEOCAPSID PROTEIN, GLYCOPROTEINS, VACCINES, ANTIGEN, SYSTEM, 11832 Microbiology and virology

وصف الملف: application/pdf

العلاقة: This work was funded by the MRC (MR/L009528/1 and MR/S007555/1 to T.A.B., MR/ N002091/1 to K.J.D. and T.A.B., MR/K024426/1 and MRC Discovery Award MC/PC/15068 to K.J.D.), the Academy of Finland (grant 309605 to I.R.), the European Research Council under the European Union’s Horizon 2020 research and innovation program (grant 649053 to J.T.H.), and National Institutes of Health (NIH) grants R41AI132047, R41AI132047-01S1, and R43AI142911 to J.W.B. The Wellcome Centre for Human Genetics (WCHG) is supported by Wellcome Centre grant 203141/Z/16/Z. Computation used the Oxford Biomedical Research Computing (BMRC) facility, a joint development between the WCHG and the Big Data Institute supported by Health Data Research UK and the National Institute of Health Research (NIHR) Oxford Biomedical Research Centre. Oxford Particle Imaging Centre was founded by a Wellcome JIF award (060208/Z/00/Z) and is supported by grants from Wellcome (093305/Z/10/Z) and the MRC. We thank Bilal Qureshi for support with electron microscopy and Jingshan Ren for advice on crystallographic data processing. We also thank Diamond Light Source (DLS) for beamtime (proposal MX19946) and the staff of beamline i03 at DLS for assistance with X-ray data collection. We further acknowledge Diamond Light Source for time on beamline Krios I under proposal EM20223-7 for access and support and for the use of cryo-EM facilities at the United Kingdom?s National Electron Bio-Imaging Centre (eBIC), funded by Wellcome, Medical Research Council (MRC) and Biotechnology and Biological Sciences Research Council (BBRSC). We acknowledge CSC?IT Center for Science, Finland, for computational resources. The following reagent was obtained through the NIH Biodefense and Emerging Infections Research Resources Repository, National Institute of Allergy and Infectious Diseases, NIH: rabbit anti-ANDV N polyclonal antibody (NR-12152). This work was funded by the MRC (MR/L009528/1 and MR/S007555/1 to T.A.B., MR/ N002091/1 to K.J.D. and T.A.B., MR/K024426/1 and MRC Discovery Award MC/PC/15068 to K.J.D.), the Academy of Finland (grant 309605 to I.R.), the European Research Council under the European Union?s Horizon 2020 research and innovation program (grant 649053 to J.T.H.), and National Institutes of Health (NIH) grants R41AI132047, R41AI132047-01S1, and R43AI142911 to J.W.B. The Wellcome Centre for Human Genetics (WCHG) is supported by Wellcome Centre grant 203141/Z/16/Z. Computation used the Oxford Biomedical Research Computing (BMRC) facility, a joint development between the WCHG and the Big Data Institute supported by Health Data Research UK and the National Institute of Health Research (NIHR) Oxford Biomedical Research Centre. Oxford Particle Imaging Centre was founded by a Wellcome JIF award (060208/Z/00/Z) and is supported by grants from Wellcome (093305/Z/10/Z) and the MRC.; Rissanen , I , Krumm , S A , Stass , R , Whitaker , A , Voss , J E , Bruce , E A , Rothenberger , S , Kunz , S , Burton , D R , Huiskonen , J T , Botten , J W , Bowden , T A & Doores , K J 2021 , ' Structural Basis for a Neutralizing Antibody Response Elicited by a Recombinant Hantaan Virus Gn Immunogen ' , mBio , vol. 12 , no. 4 , 02531 . https://doi.org/10.1128/mBio.02531-20Test; ORCID: /0000-0002-0348-7323/work/156150863; http://hdl.handle.net/10138/341549Test; f7410e78-5e80-4664-b7e8-4b0d72d83370; 000695211800002

الإتاحة: http://hdl.handle.net/10138/341549Test

المؤلفون: Rahikainen, Rolle, Rijal, Pramila, Tan, Tiong Kit, Wu, Hung-Jen, Andersson, Anne-Marie C., Barrett, Jordan R., Bowden, Thomas, Draper, Simon, Townsend, Alain, Howarth, Mark

المصدر: Angewandte Chemie, 60(1):321-330

مصطلحات موضوعية: bioconjugation, COVID-19, nanoparticle, nanotechnology, vaccines, SpyTag

العلاقة: https://repository.publisso.de/resource/frl:6426867Test; https://doi.org/10.1002/anie.202009663Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7821241Test/

الإتاحة: https://doi.org/10.1002/anie.202009663Test
https://repository.publisso.de/resource/frl:6426867Test
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7821241Test/

المؤلفون: Rahikainen, Rolle, Rijal, Pramila, Tan, Tiong Kit, Wu, Hung‐Jen, Andersson, Anne‐Marie C., Barrett, Jordan R., Bowden, Thomas A., Draper, Simon J., Townsend, Alain R., Howarth, Mark

المصدر: Angewandte Chemie; 1/4/2021, Vol. 133 Issue 1, p325-334, 10p

مصطلحات موضوعية: AMIDATION, SYMMETRY, VIRUS-like particles, NEWCASTLE disease, VACCINES, LYME disease

المؤلفون: van Doremalen, Neeltje, Lambe, Teresa, Sebastian, Sarah, Bushmaker, Trenton, Fischer, Robert, Feldmann, Friederike, Haddock, Elaine, Letko, Michael, Avanzato, Victoria A., Rissanen, Ilona, LaCasse, Rachel, Scott, Dana, Bowden, Thomas A., Gilbert, Sarah, Munster, Vincent

المصدر: PLoS Neglected Tropical Diseases; 6/6/2019, Vol. 13 Issue 6, p1-19, 19p

مصطلحات موضوعية: GOLDEN hamster, VACCINES, NIPAH virus, IN situ hybridization, PATHOGENIC viruses

مصطلحات جغرافية: BANGLADESH, MALAYSIA, ASIA

المؤلفون: Bowden, Thomas A.¹, Crispin, Max¹, Harvey, David J.², Aricescu, A. Radu¹, Grimes, Jonathan M.¹, Jones, E. Yvonne¹, Stuart, David I.¹ dave@strubi.ox.ac.uk

المصدر: Journal of Virology. Dec2008, Vol. 82 Issue 23, p11628-11636. 9p.

مصطلحات موضوعية: *NIPAH virus, *GLYCOPROTEINS, *CARBOHYDRATES, *ANTIVIRAL agents, *VACCINES, *IMMUNOTHERAPY