المؤلفون: Kwong, Jethro C.C., Al-Daqqaq, Zizo, Chelliahpillai, Yashan, Lee, Soomin, Kim, Kellie, Chan, Amy, Kuk, Cynthia, Zlotta, Alexandre R., Ringa, Maximiliano, Ali, Amna, Feifer, Andrew, Perlis, Nathan, Lee, Jason Y., Hamilton, Robert J., Fleshner, Neil E., Finelli, Antonio, Kulkarni, Girish S., Johnson, Alistair E.W.

المصدر: Urologic Oncology: Seminars and Original Investigations ; volume 42, page S53-S54 ; ISSN 1078-1439

مصطلحات موضوعية: Urology, Oncology

الإتاحة: https://doi.org/10.1016/j.urolonc.2024.01.162Test
https://api.elsevier.com/content/article/PII:S1078143924001789?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1078143924001789?httpAccept=text/plainTest

المؤلفون: Juvet, Tristan, Mari, Andrea, Lajkosz, Katherine, Wallis, Christopher JD, Kuk, Cynthia, Erlich, Annette, Krimus, Lior, Fleshner, Neil E., Kulkarni, Girish S, Zlotta, Alexandre R.

المصدر: Urologic Oncology: Seminars and Original Investigations ; volume 38, issue 11, page 850.e9-850.e15 ; ISSN 1078-1439

مصطلحات موضوعية: Urology, Oncology

الإتاحة: https://doi.org/10.1016/j.urolonc.2020.06.031Test
https://api.elsevier.com/content/article/PII:S1078143920303185?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1078143920303185?httpAccept=text/plainTest

المؤلفون: Hermanns, Thomas, Savio, Andrea J., Olkhov-Mitsel, Ekaterina, Mari, Andrea, Wettstein, Marian S., Saba, Karim, Bhindi, Bimal, Kuk, Cynthia, Poyet, Cédric, Wild, Peter J., Noon, Aidan, Bashir, Shaheena, Juvet, Tristan, Rendon, Ricardo A., Waltregny, David, van der Kwast, Theodorus, Finelli, Antonio, Kulkarni, Girish S., Fleshner, Neil E., Lo, Kirk, Bapat, Bharati, Zlotta, Alexandre R.

المساهمون: Canadian Urological Association, Astellas Research Grant Program

المصدر: Urologic Oncology: Seminars and Original Investigations ; volume 38, issue 6, page 603.e1-603.e7 ; ISSN 1078-1439

مصطلحات موضوعية: Urology, Oncology

الإتاحة: https://doi.org/10.1016/j.urolonc.2020.01.007Test
https://api.elsevier.com/content/article/PII:S1078143920300089?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1078143920300089?httpAccept=text/plainTest

المؤلفون: Zlotta, Alexandre R., Kuk, Cynthia

المصدر: European Urology ; volume 75, issue 4, page 562-563 ; ISSN 0302-2838

مصطلحات موضوعية: Urology

الإتاحة: https://doi.org/10.1016/j.eururo.2018.12.038Test
https://api.elsevier.com/content/article/PII:S0302283818310467?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0302283818310467?httpAccept=text/plainTest

المؤلفون: Kulkarni, Girish S., Hermanns, Thomas, Wei, Yanliang, Bhindi, Bimal, Satkunasivam, Raj, Athanasopoulos, Paul, Bostrom, Peter J., Li, Kathy, Templeton, Arnoud J., Sridhar, Srikala S., Chung, Peter, Bristow, Robert G., Milosevic, Michael, Warde, Padraig, Fleshner, Neil E., Jewett, Michael A.S., Bashir, Shaheena, Zlotta, Alexandre R., Kuk, Cynthia, Van Der Kwast, Theodorus H.

المساهمون: University of Zurich, Zlotta, Alexandre R

المصدر: Kulkarni, G S, Hermanns, T, Wei, Y, Bhindi, B, Satkunasivam, R, Athanasopoulos, P, Bostrom, P J, Li, K, Templeton, A J, Sridhar, S S, Chung, P, Bristow, R G, Milosevic, M, Warde, P, Fleshner, N E, Jewett, M A S, Bashir, S, Zlotta, A R, Kuk, C, Zlotta, A R & Van Der Kwast, T H 2017, ' Propensity score analysis of radical cystectomy versus bladder-sparing trimodal therapy in the setting of a multidisciplinary bladder cancer clinic ', Journal of Clinical Oncology, vol. 35, no. 20, pp. 2299-2305 . https://doi.org/10.1200/JCO.2016.69.2327Test

مصطلحات موضوعية: Male, Cancer Research, medicine.medical_treatment, 030232 urology & nephrology, 0302 clinical medicine, 1306 Cancer Research, Aged, 80 and over, Urinary bladder, Manchester Cancer Research Centre, Middle Aged, Combined Modality Therapy, Survival Rate, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, 2730 Oncology, Female, Adult, medicine.medical_specialty, Urinary Bladder, Urology, 610 Medicine & health, Antineoplastic Agents, Cystectomy, Disease-Free Survival, 03 medical and health sciences, medicine, Humans, Neoplasm Invasiveness, External beam radiotherapy, Propensity Score, Survival rate, Aged, Neoplasm Staging, Retrospective Studies, ta3126, Patient Care Team, Bladder cancer, Radiotherapy, business.industry, Carcinoma in situ, ResearchInstitutes_Networks_Beacons/mcrc, Carcinoma, medicine.disease, Surgery, Radiation therapy, 10062 Urological Clinic, Urinary Bladder Neoplasms, Propensity score matching, business, human activities, Organ Sparing Treatments

الوصف: Purpose Multidisciplinary management improves complex treatment decision making in cancer care, but its impact for bladder cancer (BC) has not been documented. Although radical cystectomy (RC) currently is viewed as the standard of care for muscle-invasive bladder cancer (MIBC), radiotherapy-based, bladder-sparing trimodal therapy (TMT) that combines transurethral resection of bladder tumor, chemotherapy for radiation sensitization, and external beam radiotherapy has emerged as a valid treatment option. In the absence of randomized studies, this study compared the oncologic outcomes between patients treated with RC or TMT by using a propensity score matched-cohort analysis. Methods Data from patients treated in a multidisciplinary bladder cancer clinic (MDBCC) from 2008 to 2013 were reviewed retrospectively. Those who received TMT for MIBC were identified and matched (for sex, cT and cN stage, Eastern Cooperative Oncology Group status, Charlson comorbidity score, treatment date, age, carcinoma in situ status, and hydronephrosis) with propensity scores to patients who underwent RC. Overall survival and disease-specific survival (DSS) were assessed with Cox proportional hazards modeling and a competing risk analysis, respectively. Results A total of 112 patients with MIBC were included after matching (56 who had been treated with TMT, and 56 who underwent RC). The median age was 68.0 years, and 29.5% had stage cT3/cT4 disease. At a median follow-up of 4.51 years, there were 20 deaths (35.7%) in the RC group (13 as a result of BC) and 22 deaths (39.3%) in the TMT group (13 as a result of BC). The 5-year DSS rate was 73.2% and 76.6% in the RC and TMT groups, respectively ( P = .49). Salvage cystectomy was performed in 6 (10.7%) of 56 patients who received TMT. Conclusion In the setting of a MDBCC, TMT yielded survival outcomes similar to those of matched patients who underwent RC. Appropriately selected patients with MIBC should be offered the opportunity to discuss various treatment options, including organ-sparing TMT.

وصف الملف: jco.2016.69.2327.pdf - application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7f85075de2dc79dfc9dba0cafaa1ff7Test
https://pubmed.ncbi.nlm.nih.gov/29454473Test

المؤلفون: Siadat, Farshid, Sykes, Jenna, Zlotta, Alexandre R., Aldaoud, Najla, Egawa, Shin, Pushkar, Dmitry, Kuk, Cynthia, Bristow, Robert G., Van Der Kwast, Theodorus, MONTIRONI, RODOLFO

المساهمون: Siadat, Farshid, Sykes, Jenna, Zlotta, Alexandre R., Aldaoud, Najla, Egawa, Shin, Pushkar, Dmitry, Kuk, Cynthia, Bristow, Robert G., Montironi, Rodolfo, Van Der Kwast, Theodorus

مصطلحات موضوعية: cribriform architecture, Gleason grading, intraductal carcinoma, latent cancer, prostate, Adenocarcinoma, Aged, Autopsy, Carcinoma, Ductal, Cystectomy, Human, Japan, Male, Neoplasm Grading, Prognosi, Prospective Studie, Prostatectomy, Prostatic Neoplasm, Russia, Urology, Oncology, Medicine (all)

الوصف: BACKGROUNDThe Gleason grading system represents the cornerstone of the management of prostate cancer. Gleason grade 4 (G4) is a heterogeneous set of architectural patterns, each of which may reflect a distinct prognostic value. METHODSWe determined the prevalence of the various G4 architectural patterns and intraductal carcinoma (IDC) in latent prostate cancer in contemporary Russian (n=220) and Japanese (n=100) autopsy prostates and in cystoprostatectomy (CP) specimens (n=248) collected in Italy. We studied the association of each G4 pattern with extraprostatic extension (EPE) and tumor volume to gain insight into their natural history. Presence of IDC and nine architectural features of Gleason grade 4 and 5 cancer were recorded. RESULTSThe prevalence of Gleason score 7 PC was higher in the autopsy series (11%) compared to the CP series (6.5%, P=0.04). The prevalence of IDC and carcinoma with a cribriform architecture was 2.2% and 3.4% in the autopsy series and 0.8% and 3.6% in the cystoprostatectomy series, respectively. In multivariable analysis, cribriform architecture was significantly associated with increased tumor volume (P<0.001) and EPE (OR:11.48, 95%CI:2.30-57.16, P=0.003). IDC was also significantly associated with EPE (OR:10.08, 95%CI:1.58-64.28, P=0.014). Small fused glands had a strong negative association with EPE in the autopsy series (OR:0.06, 95%CI:0.01-0.58, P=0.015). DISCUSSIONOur study revealed that in latent prostate cancer both cribriform architecture and IDC are uniquely associated with poor pathological outcome features. In contrast, Gleason score 7 (3+4) cancers with small-fused gland pattern might possibly include some prostate cancers with a more indolent biology.

وصف الملف: STAMPA

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/25963383; info:eu-repo/semantics/altIdentifier/wos/WOS:000358494600005; volume:75; issue:12; firstpage:1277; lastpage:1284; numberofpages:8; journal:THE PROSTATE; http://hdl.handle.net/11566/233734Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84937516827; http://onlinelibrary.wiley.com/journal/10.1002Test/(ISSN)1097-0045

الإتاحة: https://doi.org/10.1002/pros.23009Test
http://hdl.handle.net/11566/233734Test

المؤلفون: Zlotta, Alexandre R., Kuk, Cynthia

المصدر: European Urology ; volume 67, issue 3, page 458-459 ; ISSN 0302-2838

مصطلحات موضوعية: Urology

الإتاحة: https://doi.org/10.1016/j.eururo.2014.05.036Test
https://api.elsevier.com/content/article/PII:S0302283814005181?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0302283814005181?httpAccept=text/plainTest

المؤلفون: Zlotta, Alexandre R., Egawa, Shin, Pushkar, Dmitry, Govorov, Alexander, Kimura, Takahiro, Kido, Masahito, Takahashi, Hiroyuki, Kuk, Cynthia, Kovylina, Marta, Aldaoud, Najla, Fleshner, Neil, Finelli, Antonio, Klotz, Laurence, Lockwood, Gina, Sykes, Jenna, Kwast, Theodorus van der

المصدر: European Urology ; volume 66, issue 4, page 619-622 ; ISSN 0302-2838

مصطلحات موضوعية: Urology

الإتاحة: https://doi.org/10.1016/j.eururo.2014.06.026Test
https://api.elsevier.com/content/article/PII:S0302283814006009?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0302283814006009?httpAccept=text/plainTest

المؤلفون: Liu, Yu, Noon, Aidan P., Aguiar Cabeza, Eduardo, Shen, Jess, Kuk, Cynthia, Ilczynski, Christine, Ni, Ruoyu, Sukhu, Balram, Chan, Kin, Barbosa-Morais, Nuno L., Hermanns, Thomas, Blencowe, Benjamin J., Azad, Azar, van der Kwast, Theodorus H., Catto, James W.F., Zlotta, Alexandre R., Wrana, Jeffrey L.

المصدر: European Urology ; volume 66, issue 6, page 982-986 ; ISSN 0302-2838

مصطلحات موضوعية: Urology

الإتاحة: https://doi.org/10.1016/j.eururo.2014.07.045Test
https://api.elsevier.com/content/article/PII:S0302283814007350?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0302283814007350?httpAccept=text/plainTest

المؤلفون: Skeldon, Sean C., Semotiuk, Kara, Aronson, Melyssa, Holter, Spring, Gallinger, Steven, Pollett, Aaron, Kuk, Cynthia, van Rhijn, Bas, Bostrom, Peter, Cohen, Zane, Fleshner, Neil E., Jewett, Michael A., Hanna, Sally, Shariat, Shahrokh F., Van Der Kwast, Theodorus H., Evans, Andrew, Catto, Jim, Bapat, Bharati, Zlotta, Alexandre R.

المصدر: European Urology ; volume 63, issue 2, page 379-385 ; ISSN 0302-2838

مصطلحات موضوعية: Urology

الإتاحة: https://doi.org/10.1016/j.eururo.2012.07.047Test
https://api.elsevier.com/content/article/PII:S0302283812009207?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0302283812009207?httpAccept=text/plainTest