snoRNAs Offer Novel Insight and Promising Perspectives for Lung Cancer Understanding and Management
| العنوان: | snoRNAs Offer Novel Insight and Promising Perspectives for Lung Cancer Understanding and Management |
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| المؤلفون: | Tanguy Fenouil, Virginie Marcel, Chloé Morin, Jean-Jacques Diaz, Nour-El-Houda Mourksi |
| المصدر: | Cells, Vol 9, Iss 3, p 541 (2020) Cells |
| بيانات النشر: | MDPI AG, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Lung Neoplasms, Carcinogenesis, Nucleolus, Apoptosis, Review, Computational biology, Biology, medicine.disease_cause, Diagnostic tools, medicine, rrna chemical modification, Animals, Humans, RNA, Small Nucleolar, Small nucleolar RNA, Lung cancer, lcsh:QH301-705.5, Cell growth, urogenital system, General Medicine, medicine.disease, snorna, Gene Expression Regulation, Neoplastic, lung cancer, ribosome, lcsh:Biology (General), Cancer cell, Biogenesis, Signal Transduction |
| الوصف: | Small nucleolar RNAs (snoRNAs) are non-coding RNAs localized in the nucleolus, where they participate in the cleavage and chemical modification of ribosomal RNAs. Their biogenesis and molecular functions have been extensively studied since their identification in the 1960s. However, their role in cancer has only recently started to emerge. In lung cancer, efforts to profile snoRNA expression have enabled the definition of snoRNA-related signatures, not only in tissues but also in biological fluids, exposing these small RNAs as potential non-invasive biomarkers. Moreover, snoRNAs appear to be essential actors of lung cancer onset and dissemination. They affect diverse cellular functions, from regulation of the cell proliferation/death balance to promotion of cancer cell plasticity. snoRNAs display both oncogenic and tumor suppressive activities that are pivotal in lung cancer tumorigenesis and progression. Altogether, we review how further insight into snoRNAs may improve our understanding of basic lung cancer biology and the development of innovative diagnostic tools and therapies. |
| اللغة: | English |
| تدمد: | 2073-4409 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2420a8f49db32e4752e2071c0d1eaecTest https://www.mdpi.com/2073-4409/9/3/541Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d2420a8f49db32e4752e2071c0d1eaec |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20734409 |
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