دورية أكاديمية
Microrna expression profiles and changes with treatment on childhood leukemias
| العنوان: | Microrna expression profiles and changes with treatment on childhood leukemias |
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| المؤلفون: | Akpinar, F., Polat, A., Balci, Y.I., Tokgun, O., Akça, Hakan, Åženol, Hande |
| بيانات النشر: | UHOD - Uluslararasi Hematoloji Onkoloji Dergisi |
| سنة النشر: | 2020 |
| المجموعة: | Pamukkale University Repository / Pamukkale Üniversitesi Açık Erişim Arşivi |
| مصطلحات موضوعية: | MicroRNA, Childhood leukemias, let 7b, microRNA 10, microRNA 128 1, microRNA 145, microRNA 146a, microRNA 155, microRNA 204, microRNA 21, microRNA 218, microRNA 222, microRNA 23, microRNA 30, microRNA 31, microRNA 331, microRNA 372, microRNA 375, microRNA 422, microRNA 451, microRNA 520, microRNA 7, unclassified drug, acute lymphoblastic leukemia, acute myeloid leukemia, adolescent, adult, Article, cancer prognosis, cancer recurrence |
| الوصف: | MicroRNAs are non-protein coding RNAs that have recently been revealed to be effective in cancer biogenesis which effect post-transcriptional gene modification. The incidence of childhood hematologic cancers is increasing. Therefore, this study aimed to investigate the relationship between miRNA expression and its prognosis in childhood leukemias. Twenty-one patients and 5 healthy control subjects were included in the study. Out of 26 subjects, 15 were patients diagnosed with acute lymphoblastic leukemia (ALL), 6 were patients diagnosed with acute myeloblastic leukemia (AML) and 5 were healthy control subjects. Peripheral venous samples were col-lected from the patients before and 1 month after chemotherapy and their miRNA analyses were performed. Decreased expressions of let-7b, miR-31, miR-128-1, miR-218, miR-331, miR-372, miR-375, miR-422, miR-451 and miR-520 were found in patients with AL compared to the healthy control subjects. While the expression of miR-375 decreased in patients with ALL, the expressions of miR-21, miR-222, miR-30, miR-145, miR-146a and miR-155 increased. While the expression of miR-155 increased in patients with AML, the expressions of miR-10, miR-23, miR-218, miR-422 and miR-451 decreased. It was also found that while the expressions of miR-204,miR-7,miR-10, miR-30, miR-155, miR-192, miR-422, miR-451,miR-520, miR-548, miR-375, miR-1, miR-23 and miR-146a increased in patients with leukemia after the treatment, the expressions of let-7b and miR-132 decreased. A positive correlation was found between leukocyte count of patients with leukemia before the treatment and the expressions of miR-128-1 and miR-331 among miRNAs that changed after the treatment. MiRNAs play role in the pathogenesis, treatment response, relapse and prognosis of hematologic malignancies. © 2020, UHOD - Uluslararasi Hematoloji Onkoloji Dergisi. All rights reserved. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1306-133X |
| العلاقة: | UHOD - Uluslararasi Hematoloji-Onkoloji Dergisi; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://hdl.handle.net/11499/37538Test; https://doi.org/10.4999/uhod.204076Test; 30; 72; 80; 2-s2.0-85086668902; WOS:000542758200002 |
| DOI: | 10.4999/uhod.204076 |
| الإتاحة: | https://doi.org/10.4999/uhod.204076Test https://hdl.handle.net/11499/37538Test |
| حقوق: | open |
| رقم الانضمام: | edsbas.2F401B53 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 1306133X |
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| DOI: | 10.4999/uhod.204076 |