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1
المؤلفون: Meidan Ying, Xuejing Shao, Hong Zhu, Ji Cao, Bo Yang, Yifan Chen, Qiaojun He
المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 2, Pp 309-321 (2021)
Acta Pharmaceutica Sinica. Bمصطلحات موضوعية: SRC-3, nuclear receptor coactivator 3, VHL, von Hippel-Lindau tumor suppressor, RRM2, ribonucleotide reductase regulatory subunit M2, KRAS, KRAS proto-oncogene, GTPase, SNAIL1, snail family transcriptional repressor 1, medicine.medical_treatment, CRL, cullin-RING ligase, ERK, mitogen-activated protein kinase 1, NEDD8, NEDD8 ubiquitin like modifier, Review, medicine.disease_cause, JAB1, c-Jun activation domain binding protein-1, p130Cas, BCAR1 scaffold protein, Cas family member, law.invention, Targeted therapy, Degradation, 0302 clinical medicine, Ubiquitin, law, RA, retinoic acid, FBXL3, F-box and leucine rich repeat protein, Ci, cubitus interruptus, Phosphorylation, General Pharmacology, Toxicology and Pharmaceutics, Crosstalk, FBXO3/31, F-box protein 3/31, 0303 health sciences, biology, KEAP1, kelch like ECH associated protein 1, Kinase, Chemistry, KBTBD8, kelch repeat and BTB domain containing 8, CSN, COP9 signalosome, DYRK1A/B, dual-specificity tyrosine-phosphorylation-regulated kinases 1A/B, FBW7, F-box and WD repeat domain containing 7, CDT2, denticleless E3 ubiquitin protein ligase homolog, NRF2, nuclear factor, erythroid 2 like 2, TCN, triciribine hydrate, Cell biology, USP37, ubiquitin specific peptidase 37, Crosstalk (biology), XBP1, X-box binding protein 1, 030220 oncology & carcinogenesis, HCC, hepatocellular carcinomas, Vps34, phosphatidylinositol 3-kinase catalytic subunit type 3, CK1/2, casein kinase I/II, COMMD1, copper metabolism domain containing 1, KLHL3, kelch like family member 3, EMT, epithelial–mesenchymal transition, Cullin, P-TEFb, positive transcription elongation factor b, CDK2/4, cyclin dependent kinase 2/4, SPOP, speckle-type POZ protein, AIRE, autoimmune regulator, PYGO2, pygopus 2, TCOF1, treacle ribosome biogenesis factor 1, ID2, inhibitor of DNA binding 2, CHK1, checkpoint kinase 1, Kinases, FZR1, fizzy and cell division cycle 20 related 1, HIF1α, NF-κB and hypoxia inducible factor 1 subunit alpha, EXO1, exonuclease 1, ZBTB16, zinc finger and BTB domain containing 16, NOLC1, nucleolar and coiled-body phosphoprotein 1, 03 medical and health sciences, PKM2, pyruvate kinase M2 isoform, KDM2B, lysine demethylase 2B, PKC, protein kinase C, Cullin-RING ligases, medicine, BMAL1, aryl hydrocarbon receptor nuclear translocator like, ATR, ataxia telangiectasia-mutated and Rad3-related, SOCS6, suppressor of cytokine signaling 6, 030304 developmental biology, PDL1, programmed death ligand 1, HIB, Hedghog-induced MATH and BTB domain-containing protein, AKT, AKT serine/threonine kinase, lcsh:RM1-950, Ubiquitination, TRF1, telomeric repeat binding factor 1, DDB1, damage specific DNA binding protein 1, BCL2, BCL2 apoptosis regulator, CLOCK, clock circadian regulator, MYC, MYC proto-oncogene, bHLH transcription factor, lcsh:Therapeutics. Pharmacology, c-Fos, Fos proto-oncogene, AP-1 transcription factor subunit, RARα, RA receptor α, Tumorigenesis, biology.protein, Suppressor, CRY1, cryptochrome circadian regulator 1, ERG, ETS transcription factor ERG, Carcinogenesis
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f27b7f488f3a53677836e1b8e5b2722dTest
https://doi.org/10.1016/j.apsb.2020.09.007Test -
2Intrinsically disordered substrates dictate SPOP subnuclear localization and ubiquitination activity
المؤلفون: Amie K. Boal, Scott A. Showalter, Nafiseh Sabri, Roman Rohac, Emery T. Usher, Tanja Mittag
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, endocrine system diseases, SBM1, SB motif 1, Amino Acid Motifs, SPOP, Biochemistry, IDRs, intrinsically disordered regions, PBST, Triton X-100 in PBS, Ubiquitin, Pdx1, biology, diabetes, FA, fluorescence anisotropy, Nuclear Proteins, Editors' Pick, multivalency, MATH, meprin and tumor necrosis factor receptor-associated factor homology, Ubiquitin ligase, Cell biology, LLPS, liquid–liquid phase separation, Protein Transport, Ni-NTA, nickel-nitrilotriacetic acid, PDX1, SBM2, SB motif 2, Protein Binding, Research Article, DAXX, death domain-associated protein 6, SPOP, speckle-type POZ protein, endocrine system, ubiquitination, digestive system, 03 medical and health sciences, Death-associated protein 6, Humans, structure, Molecular Biology, Transcription factor, Puc, puckered protein, Homeodomain Proteins, Nucleoplasm, 030102 biochemistry & molecular biology, Cell Biology, Repressor Proteins, 030104 developmental biology, SB, SPOP-binding, biology.protein, Trans-Activators, Homeobox, AR, androgen receptor, Pdx1, pancreatic and duodenal homeobox 1, DAPI, 4′,6-diamidino-2-phenylindole
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::865b2261c9773bb5532b2ebeb6469bacTest
https://pubmed.ncbi.nlm.nih.gov/33894201Test -
3
المؤلفون: Gilbert G. Privé, Jihun Lee, Sophia A. Kenrick, Tanja Mittag, Michal Sharon, Peter Schuck, Melissa R. Marzahn, Suresh Marada, Huaying Zhao, Wesley J. Errington, Regina-Maria Kolaitis, Stacey K. Ogden, Gili Ben-Nissan, Stanley Pounds, Jennifer L. Peters, Amanda Nourse, J. Paul Taylor
المصدر: The EMBO Journal
مصطلحات موضوعية: 0301 basic medicine, Macromolecular Substances, membrane‐less organelle, speckle‐type POZ protein, Mutant, Kruppel-Like Transcription Factors, Nerve Tissue Proteins, SPOP, Oligomer, ubiquitin ligase, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, chemistry.chemical_compound, Ubiquitin, Protein Domains, Structural Biology, Zinc Finger Protein Gli3, Organelle, medicine, isodesmic self‐association, Humans, Molecular Biology, Cell Nucleus, 030102 biochemistry & molecular biology, General Immunology and Microbiology, biology, General Neuroscience, Ubiquitination, RNA, Post-translational Modifications, Proteolysis & Proteomics, Nuclear Proteins, Articles, Protein Biosynthesis & Quality Control, prostate cancer, Ubiquitin ligase, Repressor Proteins, 030104 developmental biology, medicine.anatomical_structure, chemistry, Biochemistry, biology.protein, Biophysics, Protein Multimerization, Nucleus, Protein Binding
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d98ac140a585464c6be21774026e4b9Test
http://europepmc.org/articles/PMC4910529Test -
4
المؤلفون: Christy R. Grace, Jihun Lee, Junmin Peng, Melissa R. Marzahn, Amanda Nourse, Tanja Mittag, Edmond R. Watson, Anthony A. High, Wendy K. Pierce, Brenda A. Schulman
المصدر: Journal of Molecular Biology. 428(6):1256-1271
مصطلحات موضوعية: 0301 basic medicine, Ubiquitin-Protein Ligases, Amino Acid Motifs, Plasma protein binding, SPOP, Article, 03 medical and health sciences, NMR spectroscopy, Ubiquitin, Structural Biology, cancer, Animals, Short linear motif, Speckle-type POZ protein, Molecular Biology, chemistry.chemical_classification, DNA ligase, biology, Ubiquitination, Processivity, multivalency, degron, Ubiquitin ligase, Cell biology, 030104 developmental biology, Biochemistry, chemistry, Hedgehogs, biology.protein, Degron, Protein Binding, Transcription Factors
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12958f008244d5d2c06bc515281da419Test
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5
المؤلفون: Bulatov, Emil, Ciulli, Alessio
المصدر: Biochemical Journal
مصطلحات موضوعية: Models, Molecular, Skp2, S-phase kinase-associated protein 2, Fbxl, F-box/leucine-rich motif-containing protein, SCF, Skp1–Cdc53–F-box Cdc4, DDB, damage-specific DNA-binding protein, DCAF, DDB1–Cul4A-associated factor, EloBC, ElonginB–ElonginC complex, Review Article, SV5, simian virus 5, Nrf2, nuclear factor-erythroid 2-related factor 2, Vpr, viral protein R, JA-Ile, jasmonoyl-isoleucine, CRL, Cullin–RING E3 ubiquitin ligase, HERC2, HECT domain- and RLD (regulator of chromosome condensation 1 protein-like domain) domain-containing E3 ubiquitin protein ligase 2, BCR, BTB–Cul3–Rbx1, Drug Discovery, NAE, NEDD8-activating enzyme, KLHL, Kelch-like protein, Ub, ubiquitin, IκB, inhibitor of NF-κB, Vif, virion infectivity factor, Molecular Structure, ITC, isothermal titration calorimetry, CPH, conserved within Cul7, PARC and HERC2, Cpd, compound, Aux, auxin, Cullin Proteins, structure-based design, CTD, C-terminal domain, Protac, proteolysis-targeting chimaeric molecule, Cul, Cullin, Fbw/Fbxw, F-box/WD repeat-containing protein, STAT, signal transducer and activator of transcription, GHR, growth hormone receptor, UBL, ubiquitin-like protein, FP, fluorescence polarization, NF-κB, nuclear factor κB, Cks1, cyclin-dependent protein kinase regulatory subunit 1, Rbx1, RING-box protein 1, Proteasome Inhibitors, SH2, Src homology 2, assembly, SPOP, speckle-type POZ protein, UPS, ubiquitin–proteasome system, PARC, p53-associated parkin-like cytoplasmic protein, β-TrCP, β-transducin repeat-containing protein, PPI, protein–protein interaction, small molecule, JAZ1, jasmonate/ZIM (zinc finger expressed in inflorescence) domain protein 1, Fbxo, F-box/other domain-containing protein, mTOR, mammalian target of rapamycin, NEDD, neural-precursor-cell-expressed developmentally down-regulated, ubiquitination, APC/C, anaphase-promoting complex/cyclosome, MEL26, maternal effect lethal 26, RING, really interesting new gene, CAND1, Cullin-associated NEDD8-dissociated protein 1, Cdc, cell division cycle, ubiquitin, Ubc12, ubiquitin-conjugating enzyme 12, COI1, coronatine-insensitive protein 1, CSA, Cockayne syndrome A, Humans, structure, NTD, N-terminal domain, CRBN, cereblon, Protein Structure, Quaternary, SMER3, small-molecule enhancer of rapamycin 3, CSN, COP9 (constitutive photomorphogenesis 9) signalosome complex, CBFβ, core binding factor β, IAA, indole-3-acetic acid, SOCS, suppressor of cytokine signalling, BTB, bric-a-brac/tramtrack/broad complex, MATH, meprin and TRAF (tumour necrosis factor receptor-associated factor) homology, Keap1, Kelch-like enoyl-CoA hydratase-associated protein 1, Protein Structure, Tertiary, VHL, von Hippel–Lindau, Protein Subunits, ASB, ankyrin repeat and SOCS-box, BP, β-propeller, HECT, homologous with E6-associated protein C-terminus, Drug Design, HIF-1α, hypoxia-inducible factor 1α, VPRBP, Vpr-binding protein, TIR1, transport inhibitor response 1, POZ, pox virus and zinc finger
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::5b07715f4217b08830d90ae742dc138fTest
http://europepmc.org/articles/PMC4403949Test -
6
المؤلفون: Canning, Peter, Bullock, Alex N.
المصدر: Biochemical Society Transactions
مصطلحات موضوعية: SPOP, speckle-type POZ protein, antioxidant response, drug design, BTB, broad complex/tramtrack/bric-à-brac, MATH, meprin and TRAF (tumour-necrosis-factor-receptor-associated factor) homology, Nrf2, nuclear factor erythroid 2-related factor 2, S5, Protein Structure, Secondary, Rbx, RING box protein, RING, really interesting new gene, cancer, Humans, ARE, antioxidant-response element, Molecular Targeted Therapy, ubiquitylation, Protein Structure, Quaternary, Biochemical Society Focused Meeting, degradation, Kelch-Like ECH-Associated Protein 1, KLHL, Kelch-like, BACK, BTB and C-terminal Kelch, Intracellular Signaling Peptides and Proteins, Ubiquitination, cell signalling, Cullin Proteins, Protein Structure, Tertiary, CRL, Cullin–RING ligase, HECT, homologous with E6-associated protein C-terminus, Multiprotein Complexes, KEAP1, Kelch-like ECH-associated protein 1, POZ, pox virus and zinc finger
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::839c55b704708e46a63bc6a374e7ab21Test
https://ora.ox.ac.uk/objects/uuid:92171bca-21d7-40fe-9f4e-b174e8406f7dTest