المؤلفون: Michelle A. Lawson, Jennifer M. Down, Lisa J. Crawford, Dharminder Chauhan, Andrew D Chantry, Claudia Hamilton, Jonathan J. Morgan, Treen C. M. Morris, Krishnaraj Rajalingam, Alexandra E. Irvine, Roisin McAvera, Aswini Krishnan, David Campbell

المصدر: Oncogene
Crawford, L J, Campbell, D C, Morgan, J J, Lawson, M A, Down, J M, Chauhan, D, McAvera, R M, Morris, T C, Hamilton, C, Krishnan, A, Rajalingam, K, Chantry, A D & Irvine, A E 2020, ' The E3 ligase HUWE1 inhibition as a therapeutic strategy to target MYC in Multiple Myeloma ', Oncogene, vol. 39, pp. 5001–5014 . https://doi.org/10.1038/s41388-020-1345-xTest

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Ubiquitylation, Cell Survival, Ubiquitin-Protein Ligases, Myeloma, Antineoplastic Agents, Bone Marrow Cells, Mice, SCID, Article, Proto-Oncogene Proteins c-myc, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, Ubiquitin, Mice, Inbred NOD, Cell Line, Tumor, Genetics, medicine, Animals, Humans, RNA, Small Interfering, Molecular Biology, Lenalidomide, Cell Proliferation, Gene knockdown, biology, Oncogene, Cell growth, Tumor Suppressor Proteins, Ubiquitination, Cell Cycle Checkpoints, Ubiquitin ligase, Therapeutic Index, Drug, 030104 developmental biology, medicine.anatomical_structure, chemistry, Proteasome, 030220 oncology & carcinogenesis, biology.protein, Cancer research, Female, RNA Interference, Bone marrow, Growth inhibition, Multiple Myeloma, Oligopeptides

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37220f16bcd269c548b5b079bcc895e5Test
http://europepmc.org/articles/PMC7329634Test

المؤلفون: Mariann Bienz, Somasekar Seshagiri, Arno Schad, Jean Berthelet, Ute Distler, Wilfried Roth, Stefan Tenzer, Emilie Renaud, Aswini Krishnan, Marc Fiedler, Zora Modrusan, Jing Wang, Thomas J. Musholt, Eric Stawiski, Sebastian Rosigkeit, Krishnaraj Rajalingam, Bernd Thiede

المصدر: Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications

مصطلحات موضوعية: 0301 basic medicine, Cancer therapy, Oncogene Proteins, Fusion, endocrine system diseases, General Physics and Astronomy, medicine.disease_cause, Metastasis, Papillary thyroid cancer, Fusion gene, 0302 clinical medicine, Cancer genomics, lcsh:Science, Thyroid cancer, Proteogenomics, Multidisciplinary, biology, Up-Regulation, Ubiquitin ligase, Cell Transformation, Neoplastic, Thyroid Cancer, Papillary, Lymphatic Metastasis, 030220 oncology & carcinogenesis, congenital, hereditary, and neonatal diseases and abnormalities, endocrine system, Cell Survival, Science, Ubiquitin-Protein Ligases, Article, General Biochemistry, Genetics and Molecular Biology, Thyroid carcinoma, Inhibitory Concentration 50, 03 medical and health sciences, Cell Line, Tumor, medicine, Humans, Amino Acid Sequence, Thyroid Neoplasms, neoplasms, Cell Proliferation, Base Sequence, Ubiquitin, Tumor Suppressor Proteins, Proto-Oncogene Proteins c-ret, Ubiquitination, Proteins, Oncogenes, General Chemistry, medicine.disease, 030104 developmental biology, USP9X, Trk receptor, Mutation, biology.protein, Cancer research, lcsh:Q, Protein Multimerization, Carcinogenesis

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a77e9701ec001382ad22a0405d2d7a6Test
http://link.springer.com/article/10.1038/s41467-020-15955-wTest

المؤلفون: Jaeyoung Shin, Alejandro Carpy, Krishnaraj Rajalingam, Hajime Yurugi, Arun Murali, Aswini Krishnan, Boris Macek, Masato Akutsu

المساهمون: Melino, G.

المصدر: Cell Death & Disease

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Ubiquitin-Protein Ligases, Immunology, Lysine, Apoptosis, X-Linked Inhibitor of Apoptosis Protein, macromolecular substances, CDC42, Mice, 03 medical and health sciences, Cellular and Molecular Neuroscience, Ubiquitin, Cell Movement, ddc:570, Neoplasms, Animals, Humans, Pseudopodia, cdc42 GTP-Binding Protein, biology, Protein Stability, Ubiquitination, Cell migration, Cell Biology, Actin cytoskeleton, Xenograft Model Antitumor Assays, XIAP, Ubiquitin ligase, Cell biology, Actin Cytoskeleton, 030104 developmental biology, Proteostasis, biology.protein, Original Article, biological phenomena, cell phenomena, and immunity, HeLa Cells, Signal Transduction

وصف الملف: application/octet-stream

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cb4e849b63985007b9b46be906e29dcTest
https://doi.org/10.1038/cddis.2017.305Test