التفاصيل البيبلوغرافية
| العنوان: |
Molecular signatures mostly associated with NK cells are predictive of relapse free survival in breast cancer patients. |
| المؤلفون: |
Libera Ascierto, Maria1,2,3 asciertoml@cc.nih.gov, Idowu, Michael O.4, Zhao, Yingdong5, Khalak, Hanif6, Payne, Kyle K.7, Xiang-Yang Wang8, Dumur, Catherine I.4, Bedognetti, Davide1, Tomei, Sara6, Ascierto, Paolo A.9, Shanker, Anil10, Bear, Harry D.11, Wang, Ena1, Marincola, Francesco M1,12, Maria, Andrea De2,13, Manjili, Masoud H.7 |
| المصدر: |
Journal of Translational Medicine. 2013, Vol. 11 Issue 1, p1-11. 11p. 1 Diagram, 1 Chart, 2 Graphs. |
| مصطلحات موضوعية: |
*CANCER patients, *IMMUNE system, *KILLER cells, *TUMORS, *HEREDITY |
| مستخلص: |
Background: Recent observations suggest that immune-mediated tissue destruction is dependent upon coordinate activation of immune genes expressed by cells of the innate and adaptive immune systems. Methods: Here, we performed a retrospective pilot study to investigate whether the coordinate expression of molecular signature mostly associated with NK cells could be used to segregate breast cancer patients into relapse and relapse-free outcomes. Results: By analyzing primary breast cancer specimens derived from patients who experienced either 58- 116 months (∼5-9 years) relapse-free survival or developed tumor relapse within 9-76 months (∼1-6 years) we found that the expression of molecules involved in activating signaling of NK cells and in NK cells: target interaction is increased in patients with favorable prognosis. Conclusions: The parameters identified in this study, together with the prognostic signature previously reported by our group, highlight the cooperation between the innate and adaptive immune components within the tumor microenvironment. [ABSTRACT FROM AUTHOR] |
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