التفاصيل البيبلوغرافية
| العنوان: |
FOXO transcription factors in cancer development and therapy. |
| المؤلفون: |
Coomans De Brachene, Alexandra, Demoulin, Jean-Baptiste |
| المصدر: |
Cellular and molecular life sciences, 73 (6 |
| سنة النشر: |
2016 |
| المجموعة: |
DI-fusion : dépôt institutionnel de l'Université libre de Bruxelles (ULB) |
| مصطلحات موضوعية: |
Sciences bio-médicales et agricoles, Animals, Drug Resistance, Neoplasm, Forkhead Box Protein O1, Forkhead Box Protein O3, Forkhead Transcription Factors -- genetics -- metabolism, Gene Expression Regulation, Neoplastic, Humans, Mutation, Neoplasm Invasiveness -- genetics -- pathology, Neoplasm Metastasis -- genetics -- pathology, Neoplasms -- drug therapy -- genetics -- metabolism -- pathology, Neoplastic Stem Cells -- metabolism -- pathology, Signal Transduction, Transcription Factors -- genetics -- metabolism, Cancer stem cells, Cell cycle, Cell invasion, FOXO1, FOXO3, FOXO4, Metastasis, Tumor-initiating cells |
| الوصف: |
The forkhead box O (FOXO) transcription factors are considered as tumor suppressors that limit cell proliferation and induce apoptosis. FOXO gene alterations have been described in a limited number of human cancers, such as rhabdomyosarcoma, leukemia and lymphoma. In addition, FOXO proteins are inactivated by major oncogenic signals such as the phosphatidylinositol-3 kinase pathway and MAP kinases. Their expression is also repressed by micro-RNAs in multiple cancer types. FOXOs are mediators of the tumor response to various therapies. However, paradoxical roles of FOXOs in cancer progression were recently described. FOXOs contribute to the maintenance of leukemia-initiating cells in acute and chronic myeloid leukemia. These factors may also promote invasion and metastasis of subsets of colon and breast cancers. Resistance to treatment was also ascribed to FOXO activation in multiple cases, including targeted therapies. In this review, we discuss the complex role of FOXOs in cancer development and response to therapy. ; info:eu-repo/semantics/published |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
No full-text files |
| اللغة: |
English |
| العلاقة: |
uri/info:doi/10.1007/s00018-015-2112-y; uri/info:pii/10.1007/s00018-015-2112-y; uri/info:pmid/26686861; http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/242613Test |
| الإتاحة: |
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/242613Test |
| رقم الانضمام: |
edsbas.D77D933 |
| قاعدة البيانات: |
BASE |
