دورية أكاديمية
Vascularization of Patient-Derived Tumoroid from Non-Small-Cell Lung Cancer and Its Microenvironment
| العنوان: | Vascularization of Patient-Derived Tumoroid from Non-Small-Cell Lung Cancer and Its Microenvironment |
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| المؤلفون: | Seitlinger, Joseph, Nounsi, Anasse, Idoux-Gillet, Ysia, Santos Pujol, Eloy, Lê, Hélène, Grandgirard, Erwan, Olland, Anne, Lindner, Veronique, Zaupa, Cécile, Balloul, Jean-Marc, Quemeneur, Eric, Massard, Gilbert, Falcoz, Pierre-Emmanuel, Hua, Guoqiang, Benkirane-Jessel, Nadia |
| المساهمون: | Nanomédecine Régénérative (NanoRegMed), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire Strasbourg (CHU Strasbourg), Les Hôpitaux Universitaires de Strasbourg (HUS), Faculté de chirurgie dentaire - Strasbourg, Université de Strasbourg (UNISTRA), Transgene SA Illkirch, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
| المصدر: | ISSN: 2227-9059 ; Biomedicines ; https://hal.science/hal-03761201Test ; Biomedicines, 2022, 10 (5), pp.1103. ⟨10.3390/biomedicines10051103⟩. |
| بيانات النشر: | HAL CCSD MDPI |
| سنة النشر: | 2022 |
| المجموعة: | Inserm: HAL (Institut national de la santé et de la recherche médicale) |
| مصطلحات موضوعية: | lung cancer, patient-derived tumoroid, tumor microenvironment, vascularization, [SDV.CAN]Life Sciences [q-bio]/Cancer, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, [SDV.MHEP.AHA]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], [SDV.BIO]Life Sciences [q-bio]/Biotechnology |
| الوصف: | Patient-derived tumoroid (PDT) has been developed and used for anti-drug screening in the last decade. As compared to other existing drug screening models, a PDT-based in vitro 3D cell culture model could preserve the histological and mutational characteristics of their corresponding tumors and mimic the tumor microenvironment. However, few studies have been carried out to improve the microvascular network connecting the PDT and its surrounding microenvironment, knowing that poor tumor-selective drug transport and delivery is one of the major reasons for both the failure of anti-cancer drug screens and resistance in clinical treatment. In this study, we formed vascularized PDTs in six days using multiple cell types which maintain the histopathological features of the original cancer tissue. Furthermore, our results demonstrated a vascular network connecting PDT and its surrounding microenvironment. This fast and promising PDT model opens new perspectives for personalized medicine: this model could easily be used to test all therapeutic treatments and could be connected with a microfluidic device for more accurate drug screening |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/35625840; hal-03761201; https://hal.science/hal-03761201Test; https://hal.science/hal-03761201/documentTest; https://hal.science/hal-03761201/file/islandora_156047.pdfTest; PUBMED: 35625840; PUBMEDCENTRAL: PMC9138465 |
| DOI: | 10.3390/biomedicines10051103 |
| الإتاحة: | https://doi.org/10.3390/biomedicines10051103Test https://hal.science/hal-03761201Test https://hal.science/hal-03761201/documentTest https://hal.science/hal-03761201/file/islandora_156047.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.CD80BA72 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/biomedicines10051103 |
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