التفاصيل البيبلوغرافية
| العنوان: |
C-Phycocyanin elicited antitumor efficacy via cell-cycle arrest, apoptosis induction, and invasion inhibition in esophageal squamous cell carcinoma. |
| المؤلفون: |
Zhang, Xiaqing1 (AUTHOR), Fan, Tianli2 (AUTHOR), Li, Shenglei3 (AUTHOR), Guan, Fangxia1 (AUTHOR), Zhang, Jianying4 (AUTHOR), Liu, Hongtao1 (AUTHOR) liuht1230@126.com |
| المصدر: |
Journal of Receptor & Signal Transduction Research. Apr2019, Vol. 39 Issue 2, p114-121. 8p. |
| مستخلص: |
Objectives: Mounting evidence has demonstrated that C-Phycocyanin (C-PC) exhibits marked antitumor activity in a wide type of tumors, such as pancreas cancer, breast carcinoma, lung cancer, and colon cancer. The current study aimed to confirm the antitumor efficacy of C-PC in esophageal squamous cell carcinoma (ESCC). Methods: The efficacy of C-PC was evaluated against the proliferation of ESCC cell lines EC9706 and EC1 by CCK-8 kit and in a mice model of ESCC EC9706. Cell cycle and apoptosis were investigated by flow cytometry, and cell invasion was determined via transwell chamber. Protein expression was examined by Western blots. Results: We found that C-PC exhibited anti-proliferation ability in a time-dependent manner and a dose-dependent manner in ESCC EC9706 and EC1 cells. Besides, C-PC markedly arrested cell cycle in the G0/G1 phase, induced cell apoptosis and suppressed cell invasion ability in both EC9706 and EC1 cells (p <.01). Notably, C-PC evoked the elevations of Bax, PARP, and cleaved-caspase-3 protein, but reduced cyclin D1, CDK4, Bcl-2, MMP-2, and MMP-9 expression levels. Further investigation from in vivo experiment revealed that C-PC displayed significant antitumor efficacy in the xenografted EC9706 model. Conclusions: Our data presented herein suggest C-PC exerts antitumor efficacy in ESCC. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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