دورية أكاديمية
Significance of Myelin Oligodendrocyte Glycoprotein Antibodies in CSF: A Retrospective Multicenter Study
| العنوان: | Significance of Myelin Oligodendrocyte Glycoprotein Antibodies in CSF: A Retrospective Multicenter Study |
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| المؤلفون: | Carta, Sara, Cobo Calvo, Álvaro, Armangué, Thaís, Saiz, Albert, Lechner, Christian, Rostásy, Kevin, Breu, Markus, Baumann, Matthias, Höftberger, Romana, Ayzenberg, Ilya, Schwake, Carolin, Sepulveda, Maria, Martínez-Hernández, Eugenia, Olivé-Cirera, Gemma, Arrambide, Georgina, Tintoré, Mar, Bernard-Valnet, Raphael, Du Pasquier, Renaud A, Brilot, Fabienne, Ramanathan, Sudarshini, Schanda, Kathrin, Gajofatto, Alberto, Ferrari, Sergio, Sechi, Elia, Flanagan, Eoin P, Pittock, Sean J, Redenbaugh, Vyanka, Reindl, Markus, Marignier, Romain, Mariotto, Sara |
| المساهمون: | Carta, Sara, Cobo Calvo, Álvaro, Armangué, Thaí, Saiz, Albert, Lechner, Christian, Rostásy, Kevin, Breu, Marku, Baumann, Matthia, Höftberger, Romana, Ayzenberg, Ilya, Schwake, Carolin, Sepulveda, Maria, Martínez-Hernández, Eugenia, Olivé-Cirera, Gemma, Arrambide, Georgina, Tintoré, Mar, Bernard-Valnet, Raphael, Du Pasquier, Renaud A, Brilot, Fabienne, Ramanathan, Sudarshini, Schanda, Kathrin, Gajofatto, Alberto, Ferrari, Sergio, Sechi, Elia, Flanagan, Eoin P, Pittock, Sean J, Redenbaugh, Vyanka, Reindl, Marku, Marignier, Romain, Mariotto, Sara |
| سنة النشر: | 2023 |
| المجموعة: | Università degli Studi di Verona: Catalogo dei Prodotti della Ricerca (IRIS) |
| مصطلحات موضوعية: | All Demyelinating disease (CNS), Acute disseminated encephalomyelitis, Transverse myelitis |
| الوصف: | Background and Objectives: Although the diagnosis of myelin oligodendrocyte glycoprotein antibody associated disease (MOGAD) is based on serum MOG antibodies (MOG-Abs) positivity, patients with coexisting or restricted MOG-Abs in the CSF have been reported. The aim of this study is to characterize the relevance of CSF MOG-Abs positivity in clinical practice. Methods: Eleven medical centres retrospectively collected clinical and laboratory data of adult and pediatric patients with suspected inflammatory CNS disease and MOG-Abs positivity in serum and/or CSF, using live cell-based assays. Comparisons were performed using parametric or non-parametric tests, as appropriate. Potential factors of unfavourable outcomes were explored by Cox proportional hazard models and logistic regression. Results: The cohort included 255 patients: 139 (55%) females and 132 (52%) children (i.e. <18 year-old). Among them, 145 patients (56.8%) had MOG-Abs in both serum and CSF (MOG-Abs seropositive and CSF positive), 79 (31%) only in serum (MOG-Abs seropositive and CSF negative), and 31 (12%) only in CSF (MOG-Abs seronegative and CSF positive). MOG-Abs seronegative and CSF positive predominated in adults (22% vs 3% of children), presented more commonly with motor (n=14, 45%) and sensory symptoms (n=13, 42%), and all but 4 (2 MS, 1 polyradiculoneuritis, 1 Susac syndrome) had a final diagnosis compatible with MOGAD. When comparing seropositive patients according to MOG-Abs CSF status, MOG-Abs seropositive and CSF positive patients had a higher EDSS at nadir during the index event (median 4.5, IQR 3.0-7.5 vs. 3.0, IQR 2.0-6.8, p=0.007) and presented more commonly with sensory (45.5% vs. 24%, p=0.002), motor (33.6% vs 19%, p=0.021), and sphincter symptoms (26.9% vs 7.8%, p=0.001) than MOG-Abs seropositive and CSF negative. At last follow-up, MOG-Abs seropositive and CSF positive cases had more often persistent sphincter dysfunction (17.3% vs 4.3%, p=0.008). Compared with seropositive patients, those MOG-Abs seronegative and CSF positive ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/36526426; info:eu-repo/semantics/altIdentifier/wos/WOS:000999778600014; volume:100; issue:11; firstpage:e1095; lastpage:e1108; numberofpages:14; journal:NEUROLOGY; https://hdl.handle.net/11562/1085995Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85150224576; https://doi.org/10.1212/WNL.0000000000201662Test |
| DOI: | 10.1212/WNL.0000000000201662 |
| الإتاحة: | https://doi.org/10.1212/WNL.0000000000201662Test https://hdl.handle.net/11562/1085995Test |
| رقم الانضمام: | edsbas.9DE09D3A |
| قاعدة البيانات: | BASE |
| DOI: | 10.1212/WNL.0000000000201662 |
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