التفاصيل البيبلوغرافية
| العنوان: |
An XRCC1 polymorphism is associated with the outcome of patients with lymphoma undergoing autologous stem cell transplant. |
| المؤلفون: |
Guillem, Vicent M., Arbona, Cristina, Hernández-Boluda, Juan Carlos, Terol, María José, Goterris, Rosa, Solano, Carlos, Tormo, Mar |
| المصدر: |
Leukemia & Lymphoma; Jul2011, Vol. 52 Issue 7, p1249-1254, 6p, 3 Charts, 2 Graphs |
| مصطلحات موضوعية: |
GENETIC polymorphisms, LYMPHOMAS, STEM cell transplantation, HUMAN genetic variation, CANCER relapse, DNA repair, PATIENTS, CANCER treatment |
| مستخلص: |
High-dose chemotherapy supported by autologous stem cell transplant (ASCT) remains the treatment of choice for patients with lymphoma failing first-line chemotherapy. Recent evidence suggests a relationship between the genetic variations in genes involved in DNA repair and the outcome of patients with a number of malignancies. In this work, we retrospectively evaluated the influence of an XRCC1 polymorphism (rs25487) on the treatment results in a series of 73 patients with lymphoma subjected to ASCT. The factors correlated to overall survival were the disease status at transplant and XRCC1 genotype. Carriers of a mutant A allele had a two-fold higher risk of death than those with the wild-type genotype. In addition, patients harboring one or two copies of the A allele (GA/AA) were 4.5-fold more likely to develop therapy-related acute myeloid (t-AML). Thus, the cumulative probability of t-AML at 10 years was 37 ±± 13%% in patients with the mutant A allele as compared to 8.5 ±± 6%% in the remaining cases ( p == 0.04). Our findings suggest that genetic variation in the DNA repair gene XRCC1 may play a role in the results of transplant in patients with lymphoma. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
