دورية أكاديمية
Transcriptional Regulation of Postnatal Cardiomyocyte Maturation and Regeneration
| العنوان: | Transcriptional Regulation of Postnatal Cardiomyocyte Maturation and Regeneration |
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| المؤلفون: | Stephanie L. Padula, Nivedhitha Velayutham, Katherine E. Yutzey |
| المصدر: | International Journal of Molecular Sciences, Vol 22, Iss 6, p 3288 (2021) |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | cardiomyocyte, transcription factors, nucleation, polyploidization, hypertrophy, sarcomere, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | During the postnatal period, mammalian cardiomyocytes undergo numerous maturational changes associated with increased cardiac function and output, including hypertrophic growth, cell cycle exit, sarcomeric protein isoform switching, and mitochondrial maturation. These changes come at the expense of loss of regenerative capacity of the heart, contributing to heart failure after cardiac injury in adults. While most studies focus on the transcriptional regulation of embryonic or adult cardiomyocytes, the transcriptional changes that occur during the postnatal period are relatively unknown. In this review, we focus on the transcriptional regulators responsible for these aspects of cardiomyocyte maturation during the postnatal period in mammals. By specifically highlighting this transitional period, we draw attention to critical processes in cardiomyocyte maturation with potential therapeutic implications in cardiovascular disease. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| العلاقة: | https://www.mdpi.com/1422-0067/22/6/3288Test; https://doaj.org/toc/1661-6596Test; https://doaj.org/toc/1422-0067Test |
| DOI: | 10.3390/ijms22063288 |
| الوصول الحر: | https://doaj.org/article/eeaa7b65732d414e8eeab4b7b9d74ea9Test |
| رقم الانضمام: | edsdoj.7b65732d414e8eeab4b7b9d74ea9 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms22063288 |