Gene-by-Psychosocial Factor Interactions Influence Diastolic Blood Pressure in European and African Ancestry Populations: Meta-Analysis of Four Cohort Studies
| العنوان: | Gene-by-Psychosocial Factor Interactions Influence Diastolic Blood Pressure in European and African Ancestry Populations: Meta-Analysis of Four Cohort Studies |
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| المؤلفون: | Mario Sims, Kalyn Yasutake, Ana V. Diez Roux, Alanna C. Morrison, Jennifer A. Smith, Scott M. Ratliff, Sharon L.R. Kardia, Solomon K. Musani, Wei Zhao, Gerardo Heiss, Kari E. North, Stanford Mwasongwe, Michael Griswold, Jessica D. Faul, Yan Gao, David R. Weir, Kathryn M. Rose, Carmella August, Yan V. Sun, Aravinda Chakravarti, Eric Boerwinkle, Belinda L. Needham |
| المصدر: | International Journal of Environmental Research and Public Health; Volume 14; Issue 12; Pages: 1596 International Journal of Environmental Research and Public Health International Journal of Environmental Research and Public Health, Vol 14, Iss 12, p 1596 (2017) International journal of environmental research and public health, vol 14, iss 12 |
| بيانات النشر: | Multidisciplinary Digital Publishing Institute, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Health, Toxicology and Mutagenesis, lcsh:Medicine, Blood Pressure, 030204 cardiovascular system & hematology, Toxicology, gene-by-environment interaction, Cohort Studies, 0302 clinical medicine, Risk Factors, 2.1 Biological and endogenous factors, Medicine, Psychology, genetics, Aetiology, Gene–environment interaction, education.field_of_study, Depression, blood pressure, hypertension, non-burden test, socioeconomic status, psychosocial factors, depression, chronic burden, Mental Health, Meta-analysis, Trait, Psychosocial, Cohort study, Population, White People, Article, 03 medical and health sciences, Clinical Research, Behavioral and Social Science, Genetics, Humans, education, Socioeconomic status, business.industry, Human Genome, lcsh:R, Public Health, Environmental and Occupational Health, United States, Black or African American, 030104 developmental biology, Blood pressure, Socioeconomic Factors, Gene-Environment Interaction, business, Demography |
| الوصف: | Inter-individual variability in blood pressure (BP) is influenced by both genetic and non-genetic factors including socioeconomic and psychosocial stressors. A deeper understanding of the gene-by-socioeconomic/psychosocial factor interactions on BP may help to identify individuals that are genetically susceptible to high BP in specific social contexts. In this study, we used a genomic region-based method for longitudinal analysis, Longitudinal Gene-Environment-Wide Interaction Studies (LGEWIS), to evaluate the effects of interactions between known socioeconomic/psychosocial and genetic risk factors on systolic and diastolic BP in four large epidemiologic cohorts of European and/or African ancestry. After correction for multiple testing, two interactions were significantly associated with diastolic BP. In European ancestry participants, outward/trait anger score had a significant interaction with the C10orf107 genomic region (p = 0.0019). In African ancestry participants, depressive symptom score had a significant interaction with the HFE genomic region (p = 0.0048). This study provides a foundation for using genomic region-based longitudinal analysis to identify subgroups of the population that may be at greater risk of elevated BP due to the combined influence of genetic and socioeconomic/psychosocial risk factors. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1660-4601 |
| DOI: | 10.3390/ijerph14121596 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ff39fab976d63dd8d27769541cd7878Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9ff39fab976d63dd8d27769541cd7878 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16604601 |
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| DOI: | 10.3390/ijerph14121596 |