المؤلفون: Lim, Soo, Son, Kyu R, Song, In C, Park, Ho S, Jin, Cheng J, Jang, Hak C, Park, Kyong S, Kim, Young-Bum, Lee, Hong K

المساهمون: 임수, 김용범, 이홍규

مصطلحات موضوعية: Abdomen/*anatomy & histology, Adipose Tissue/*anatomy & histology, Animals, Area Under Curve, Body Weight, Dietary Fats, Liver/*anatomy & histology, Magnetic Resonance Spectroscopy, Male, Muscle, Skeletal/*anatomy & histology, Obesity/*radiography, Oxygen Consumption, Rats, Sprague-Dawley, Tomography, X-Ray Computed, Insulin Resistance

الوصف: Intrahepatic or intramuscular lipid (IHL/IML) content has been reported to be correlated with insulin resistance. Visceral fat has also been shown to be associated with insulin resistance. Thus, we investigated whether IHL/IML or visceral fat content is more closely associated with insulin resistance. Twenty Sprague-Dawley rats were divided into two groups based on regular chow diet (RCD) or high-fat diet (HFD; 40% fat). The insulin-sensitivity index (ISI) was determined by euglycemic glucose clamp study, the amount of visceral fat by computed tomography (CT), and the IHL/IML content by magnetic resonance spectroscopy (MRS). Weight, food, and water intake, physical activity, energy expenditure, lipid profile, adiponectin, and high-sensitivity C-reactive protein (hsCRP) levels were measured. At the study end point, visceral fat, and the IHL/IML content were higher in the HFD group than in the RCD group. The IHL/IML content was more highly correlated with ISI than was visceral fat amount. Stronger correlations were also found between adiponectin or hsCRP level and IML/IHL content than visceral fat, especially in the HFD group. Furthermore, the IHL/IML content was significantly associated with the ISI in the multiple regression models but visceral fat was not. There was clear discrimination between RCD and HFD groups in scatter plots of IML/IHL against the ISI, but substantial overlap in that of visceral fat against the ISI. This result suggests that IHL/IML contents are closely related with insulin resistance or atherosclerosis and is a better metabolic index of insulin sensitivity than the visceral fat.

العلاقة: Obesity (Silver Spring). 2009;17(1):188-195; 1930-7381 (Print); http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18948962Test; http://www.nature.com/oby/journal/v17/n1/pdf/oby2008486a.pdfTest; https://hdl.handle.net/10371/67853Test

الإتاحة: https://doi.org/10.1038/oby.2008.486Test
https://hdl.handle.net/10371/67853Test
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18948962Test
http://www.nature.com/oby/journal/v17/n1/pdf/oby2008486a.pdfTest

المؤلفون: Choi, Sung Hee, Kwak, Soo Heon, Lee, Yenna, Moon, Min Kyung, Lim, Soo, Park, Young Joo, Jang, Hak C., Kim, Min Seon

المصدر: Clinical Endocrinology; Nov2011, Vol. 75 Issue 5, p628-635, 8p, 6 Charts

مصطلحات موضوعية: BLOOD plasma, METABOLIC syndrome, ATHEROSCLEROSIS risk factors, TYPE 2 diabetes, OBESITY, TOMOGRAPHY

مستخلص: Summary Objective Vaspin is visceral adipose-tissue-derived adipokine, which has an insulin-sensitizing effect in obese type 2 diabetic rodent models. As adipokines may serve as a link between visceral adiposity and atherosclerosis, we investigated whether plasma vaspin concentrations were associated with the metabolic syndrome and coronary atherosclerosis. Design and Methods We measured fasting plasma vaspin levels in 81 subjects with the metabolic syndrome and 241 age- and sex-matched control subjects without the metabolic syndrome using the enzyme-linked immunosorbent assay. Multi-detector row cardiac computed tomography was performed to evaluate coronary atherosclerosis. We analysed sex-specific plasma vaspin concentrations according to the presence of the metabolic syndrome and the severity of coronary atherosclerosis. Results Plasma vaspin concentrations were significantly higher in men with the metabolic syndrome compared with those without the metabolic syndrome [median 0·60 (inter-quartile range 0·40-0·99) ng/ml vs 0·40 (0·26-0·66) ng/ml, P = 0·002]. There was a positive correlation between plasma vaspin concentrations and body mass index, waist circumference, and per cent body fat in men. However, these relationships were not found in women. Plasma vaspin concentrations were associated with the presence and severity of coronary artery stenosis such as higher Agatstone calcium score, number of diseased vessels and characteristics of coronary artery plaque only in women. Conclusions Higher plasma vaspin concentrations are significantly associated with metabolic syndrome in men. In women, vaspin concentrations are associated with coronary atherosclerosis. Further studies regarding the role of vaspin in the pathogenesis of obesity and atherosclerosis are required. [ABSTRACT FROM AUTHOR]

: Copyright of Clinical Endocrinology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Soo Lim, Sung Hee Choi, Young Joo Park, Kyong Soo Park, Hong Kyu Lee, Jang, Hak C., Cho, Nam H., Metzger, Boyd E.

المصدر: Diabetes Care; Feb2007, Vol. 30 Issue 2, p348-353, 6p, 2 Charts, 1 Graph

مصطلحات موضوعية: INSULIN resistance, DIABETES in women, TYPE 2 diabetes, OVERWEIGHT women, GLUCOSE tolerance tests, BIOELECTRIC impedance, TOMOGRAPHY

مستخلص: OBJECTIVE -- The purpose of this study was to investigate the insulin sensitivity and visceral fatness in women with previous gestational diabetes mellitus (GDM), who are prone to develop type 2 diabetes. RESEARCH DESIGN AND METHODS -- A 75-g oral glucose tolerance test (OGTT) performed 1 year postpartum identified 21 GAD^- women with previous GDM and impaired glucose tolerance (GDM-IGT). Sixty age- and BMI-matched women with normal glucose tolerance (GDM-NGT) were selected by 1:3 matching to the GDM-IGT group. Another 18 women with normal glucose metabolism during a previous pregnancy and no family history of diabetes were recruited as the normal control group. Age and BMI matching was performed using a range of ± 1.0 years and ± 1.0 kg/m², respectively. Total body fat was measured by tetrapolar bioelectrical impedance, and visceral fat was determined using a single cut of a computed tomography scan. Insulin sensitivity was determined by the minimal model technique using the frequently sampled intravenous glucose tolerance test. RESULTS -- One year postpartum, visceral fat was greater in the GDM-IGT group than in the age- and BMI-matched GDM-NGT or normal control groups. The insulin sensitivity index was lower in the GDM-IGT group than in the GDM-NGT or normal control groups. β-Cell function, as measured by the acute insulin response to glucose, was also lower in GDM-IGT. CONCLUSIONS -- High body fat content, especially visceral fat content, and a low insulin response to glucose seem to contribute simultaneously to the development of impaired glucose metabolism in Korean women with previous GDM. [ABSTRACT FROM AUTHOR]

: Copyright of Diabetes Care is the property of American Diabetes Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)