التفاصيل البيبلوغرافية
| العنوان: |
Engineered Biocompatible and Stable Dipeptide Hydrogel with Tunable Mechanical and Cell Growth Properties to Embolden Neuroglial Cell Growth. |
| المؤلفون: |
Mandal, Saurabh, Dube, Taru, Mohapatra, Ashish K., Choudhury, Samraggi, Khanam, Farheen, Yadav, Pratik, Chauhan, Virander S., Mishra, Jibanananda, Panda, Jiban J. |
| المصدر: |
International Journal of Peptide Research & Therapeutics; Dec2021, Vol. 27 Issue 4, p2795-2808, 14p |
| مصطلحات موضوعية: |
CELLULAR mechanics, HYDROGELS, CELL growth, NEUROGLIA, TISSUE scaffolds |
| مستخلص: |
Physical properties of a tissue engineering scaffold play a crucial role in maneuvering the cellular fate. Scaffold properties have been shown to significantly influence cellular growth kinetics as well as overall cell behavior. The purpose of the present investigation was to investigate the effect of varying physical properties of a dipeptide-hydrogel, on the nature of growth and spreading pattern of C6 glial cells cultured on it. It was observed that the dipeptide, phenylalanine-dehydrophenylalanine (Phe-ΔPhe), which could form stable self-supportive hydrogel after self-assembly, demonstrated diverse physical properties like variation in fiber dimensions based on the conditions under which it was made to self-assemble. These gel parameters further controlled the nature of glial cell viability, growth, and spreading on them. With such tunability in scaffold properties along with the differential glial cell growth supporting behavior, this dipeptide hydrogel offers great potential for being used as a neural tissue engineering scaffold. Graphical illustration of biocompatible dipeptide (FΔF) gel formation by virtue of self-assembly phenomenon at various solvents and salt concentrations and its impact on glial cells (C6) growth. The experiment demonstrated formation of hydrogels with different fiber dimensions on variation of self-assembling conditions such as salt concentration/solvent which modulated cellular behavior, especially the growth and spreading of glial cells on the dipeptide hydrogels with varied fiber properties. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
