دورية أكاديمية
Low-risk Prostate Cancer: Identification, Management, and Outcomes.
| العنوان: | Low-risk Prostate Cancer: Identification, Management, and Outcomes. |
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| المؤلفون: | Moschini, M, Carroll, PR, Eggener, SE, Epstein, JI, Graefen, M, Montironi, R, Parker, C |
| المساهمون: | Parker, Chris, Marsden |
| سنة النشر: | 2017 |
| المجموعة: | The Institute of Cancer Research (ICR): Publications Repository |
| مصطلحات موضوعية: | Humans, Prostatic Neoplasms, Kallikreins, Prostate-Specific Antigen, Magnetic Resonance Imaging, Biopsy, Neoplasm Staging, Treatment Outcome, Prostatectomy, Risk Assessment, Risk Factors, Predictive Value of Tests, Patient Selection, Time Factors, Male, Watchful Waiting, Neoplasm Grading, Biomarkers, Tumor, Clinical Decision-Making |
| الوصف: | Context The incidence of low-risk prostate cancer (PCa) has increased as a consequence of prostate-specific antigen testing.Objective In this collaborative review article, we examine recent literature regarding low-risk PCa and the available prognostic and therapeutic options.Evidence acquisition We performed a literature review of the Medline, Embase, and Web of Science databases. The search strategy included the terms: prostate cancer, low risk, active surveillance, focal therapy, radical prostatectomy, watchful waiting, biomarker, magnetic resonance imaging, alone or in combination.Evidence synthesis Prospective randomized trials have failed to show an impact of radical treatments on cancer-specific survival in low-risk PCa patients. Several series have reported the risk of adverse pathologic outcomes at radical prostatectomy. However, it is not clear if these patients are at higher risk of death from PCa. Long-term follow-up indicates the feasibility of active surveillance in low-risk PCa patients, although approximately 30% of men starting active surveillance undergo treatment within 5 yr. Considering focal therapies, robust data investigating its impact on long-term survival outcomes are still required and therefore should be considered experimental. Magnetic resonance imaging and tissue biomarkers may help to predict clinically significant PCa in men initially diagnosed with low-risk disease.Conclusions The incidence of low-risk PCa has increased in recent years. Only a small proportion of men with low-risk PCa progress to clinical symptoms, metastases, or death and prospective trials have not shown a benefit for immediate radical treatments. Tissue biomarkers, magnetic resonance imaging, and ongoing surveillance may help to identify those men with low-risk PCa who harbor more clinically significant disease.Patient summary Low-risk prostate cancer is very common. Active surveillance has excellent long-term results, while randomized trials have failed to show a beneficial impact of immediate radical ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | Print-Electronic; 249; application/pdf |
| اللغة: | English |
| تدمد: | 0302-2838 1873-7560 |
| العلاقة: | European urology, 2017, 72 (2), pp. 238 - 249; https://repository.icr.ac.uk/handle/internal/656Test |
| DOI: | 10.1016/j.eururo.2017.03.009 |
| الإتاحة: | https://doi.org/10.1016/j.eururo.2017.03.009Test https://repository.icr.ac.uk/handle/internal/656Test |
| حقوق: | https://www.rioxx.net/licenses/all-rights-reservedTest |
| رقم الانضمام: | edsbas.D1D6681F |
| قاعدة البيانات: | BASE |
| تدمد: | 03022838 18737560 |
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| DOI: | 10.1016/j.eururo.2017.03.009 |