التفاصيل البيبلوغرافية
| العنوان: |
Early impairment of somatosensory evoked potentials in very young children with achondroplasia with foramen magnum stenosis. |
| المؤلفون: |
Fornarino, Stefania1, Rossi, Daniela Paola1, Severino, Mariasavina2, Pistorio, Angela3, Allegri, Anna Elsa Maria4, Martelli, Simona1, Doria Lamba, Laura1, Lanteri, Paola1 paolalanteri@gaslini.org |
| المصدر: |
Developmental Medicine & Child Neurology. Feb2017, Vol. 59 Issue 2, p192-198. 7p. |
| مصطلحات موضوعية: |
*SOMATOSENSORY disorders, *ACHONDROPLASIA, *SPINAL stenosis, *OSTEOCHONDRODYSPLASIAS, *SENSORY disorders, *PARESTHESIA, *SPINAL cord, *STENOSIS, *AGE distribution, *TIBIAL nerve, *SOMATOSENSORY evoked potentials, *MAGNETIC resonance imaging, *FORAMEN magnum, *ELECTRIC stimulation, *REACTION time, *RECEIVER operating characteristic curves, *DISEASE complications |
| مستخلص: |
Aim: To evaluate the contribution of somatosensory evoked potentials after median nerve (MN-SEPs) and posterior tibial nerve (PTN-SEPs) stimulation in functional assessment of cervical and lumbar spinal stenosis in children with achondroplasia.Method: We reviewed MN-SEPs, PTN-SEPs, and spinal magnetic resonance imaging (MRI) examinations performed in 58 patients with achondroplasia (25 males, 33 females; age range 21d-16y 10mo; mean age 4y 3mo [SD 4y 1mo]). Patients were subdivided into four age categories: <2 years, between 2 to 4 years, between 4 to 8 years, and ≥8 years. The peak latency of P37 for PTN-SEPs, the peak latencies of N11, N13, P14, and N20, and the N13-N20 interpeak latency (IPL) for MN-SEPs were collected; the diagnostic accuracy measures of these parameters (analysis of receiver operating characteristic [ROC] curves) with respect to the presence of foramen magnum or lumbar spinal stenosis were analysed in each age category.Results: The ROC curve analysis showed that the most sensitive parameter in detecting the presence of foramen magnum stenosis was P37 latency in the first two age categories (<2y and ≥2-4y; sensitivity 0.63, specificity 1.00, and sensitivity 1.00, specificity 0.75 respectively). In the third age category (≥4-8y), the most sensitive parameter in detecting the presence of foramen magnum stenosis was IPLs N13-N20 (sensitivity 0.73, specificity 0.87), whereas in the last age category (≥8y), the most important parameter was N20 latency (sensitivity 0.75, specificity 0.77).Interpretation: In children with achondroplasia, the cortical component of PTN-SEPs is more sensitive than the cortical component and central conduction time of MN-SEPs in detection of cervical spinal cord compression at early ages. [ABSTRACT FROM AUTHOR] |
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