التفاصيل البيبلوغرافية
| العنوان: |
In vivo fate of 125I SS-B (La) injected into mice. |
| المؤلفون: |
Schrieber, L., Erhardt, C.C., Melsom, R.D., Venables, P.J.W., McCarthy, D.A., Mumford, P.A., Horsfall, A. C., Maini, R. N. |
| المصدر: |
Immunology; Apr83, Vol. 48 Issue 4, p771-778, 8p |
| مصطلحات موضوعية: |
ANTIGENS, PROTEINS, THYMUS, SERUM albumin, IMMUNOLOGY, IMMUNOGLOBULINS |
| مستخلص: |
The fate of the radiolabelled soluble cellular antigen SS-B (La) was compared with that of other 125I-labelled proteins of known molecular weight (MW) and electrostatic charge, following i.v. injection into BALB/c mice. The plasma half-life of @125I-SS-B was 3 min, while that of 125I-bovine serum albumin (similar MW and electrostatic charge) was 270 min. 125I-heat-aggregated IgG (MW > 1 × 106) and 125I-7S human IgG (MW 168,000) had plasma half-lives of 40 min and greater than 300 min, respectively. Liver and kidney showed preferential uptake of 125I-SS-B, followed by a rapid decrease in radioactivity. During this time iow MW, trichloroacetic acid (TCA) soluble, material appeared in urine. This suggests a specific uptake mechanism followed by a catabolic phase. These studies demonstrate that normal mice remove 125-SS-B rapidly from the circulation and then degrade it. This rapid antigen elimination may protect against the induction of potentially harmful autoantibody responses. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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