دورية أكاديمية
Effects of testosterone and exercise training on bone microstructure of rats
| العنوان: | Effects of testosterone and exercise training on bone microstructure of rats |
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| المؤلفون: | Catarina Jota-Baptista, Ana I. Faustino-Rocha, Margarida Fardilha, Rita Ferreira, Paula A. Oliveira, Marta Regueiro-Purriños, José A. Rodriguez-Altonaga, José M. Gonzalo-Orden, Mário Ginja |
| المصدر: | Veterinary World, Vol 15, Iss 3, Pp 627-633 (2022) |
| بيانات النشر: | Veterinary World, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Animal culture LCC:Veterinary medicine |
| مصطلحات موضوعية: | bone, exercise training, hypogonadism, micro-computed tomography, osteoporosis, testosterone, Animal culture, SF1-1100, Veterinary medicine, SF600-1100 |
| الوصف: | Background and Aim: Male hypogonadism results from failure to produce physiological levels of testosterone. Testosterone in men is essential in masculine development, sperm production, and adult man's health. Osteoporosis is one of the consequences of hypogonadism. Regular physical exercise and exogenous testosterone administration are frequently used to prevent or treat this condition. This study aimed to understand the effects of lifelong exercise training and testosterone levels (isolated and together) in the main bone structure parameters. Materials and Methods: A total of 24 rats were used and randomly divided into four groups: Control group (CG; n=6), exercised group (EG, n=6), testosterone group (TG, n=6), and testosterone EG (TEG, n=6). A micro-computed tomography equipment was used to evaluate 15 bone parameters. Results: Both factors (exercise training and testosterone) seem to improve the bone resistance and microstructure, although in different bone characteristics. Testosterone influenced trabecular structure parameters, namely, connectivity density, trabecular number, and trabecular space. The exercise promoted alterations in bone structure as well, although, in most cases, in different bone structure parameters as bone mineral density and medullar mineral density. Conclusion: Overall, exercise and testosterone therapy seems to have a synergistic contribution to the general bone structure and resistance. Further studies are warranted, comparing different individual factors, as gender, lifestyle, or testosterone protocols, to constantly improve the medical management of hypogonadism (and osteoporosis). |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0972-8988 2231-0916 |
| العلاقة: | http://www.veterinaryworld.org/Vol.15/March-2022/11.pdfTest; https://doaj.org/toc/0972-8988Test; https://doaj.org/toc/2231-0916Test |
| DOI: | 10.14202/vetworld.2022.627-633 |
| الوصول الحر: | https://doaj.org/article/7a6c72c930fe46e995d8fe64d392761aTest |
| رقم الانضمام: | edsdoj.7a6c72c930fe46e995d8fe64d392761a |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 09728988 22310916 |
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| DOI: | 10.14202/vetworld.2022.627-633 |