التفاصيل البيبلوغرافية
| العنوان: |
HIV Infection, Tenofovir, and Urine α1-Microglobulin: ACross-sectional Analysis in the Multicenter AIDS Cohort Study |
| المؤلفون: |
Jotwani, Vasantha, Scherzer, Rebecca, Estrella, Michelle M, Jacobson, Lisa P, Witt, Mallory D, Palella, Frank J, Macatangay, Bernard, Bennett, Michael, Parikh, Chirag R, Ix, Joachim H, Shlipak, Michael G |
| المصدر: |
American Journal of Kidney Diseases, vol 68, iss 4 |
| بيانات النشر: |
eScholarship, University of California |
| سنة النشر: |
2016 |
| المجموعة: |
University of California: eScholarship |
| مصطلحات موضوعية: |
Medical Microbiology, Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Infectious Diseases, Prevention, Kidney Disease, Clinical Trials and Supportive Activities, HIV/AIDS, Infection, Good Health and Well Being, Alpha-Globulins, Anti-HIV Agents, Cohort Studies, Cross-Sectional Studies, HIV Infections, Humans, Kidney Tubules, Proximal, Male, Middle Aged, Tenofovir, Tenofovir disoproxil fumarate, nephrotoxicity, HIV infection, proximal tubular dysfunction, tubular toxicity, biomarker, urine alpha(1)-microglobulin, kidney damage |
| جغرافية الموضوع: |
571 - 581 |
| الوصف: |
BackgroundTenofovir disoproxil fumarate (TDF) can cause proximal tubular damage and chronic kidney disease in human immunodeficiency virus (HIV)-infected individuals. Urine α1-microglobulin (A1M), a low-molecular-weight protein indicative of proximal tubular dysfunction, may enable earlier detection of TDF-associated tubular toxicity.Study designCross-sectional.Setting & participants883 HIV-infected and 350 -uninfected men enrolled in the Multicenter AIDS Cohort Study.PredictorsHIV infection and TDF exposure.OutcomeUrine A1M level.ResultsUrine A1M was detectable in 737 (83%) HIV-infected and 202 (58%) -uninfected men (P<0.001). Among HIV-infected participants, 573 (65%) were current TDF users and 112 (13%) were past TDF users. After multivariable adjustment including demographics, traditional kidney disease risk factors, and estimated glomerular filtration rate, HIV infection was associated with 136% (95% CI, 104%-173%) higher urine A1M levels and 1.5-fold (95% CI, 1.3- to 1.6-fold) prevalence of detectable A1M. When participants were stratified by TDF exposure, HIV infection was associated with higher adjusted A1M levels, by 164% (95% CI, 127%-208%) among current users, 124% (95% CI, 78%-183%) among past users, and 76% (95% CI, 45%-115%) among never users. Among HIV-infected participants, each year of cumulative TDF exposure was associated with 7.6% (95% CI, 5.4%-9.9%) higher A1M levels in fully adjusted models, a 4-fold effect size relative to advancing age (1.8% [95% CI, 0.9%-2.7%] per year). Each year since TDF treatment discontinuation was associated with 4.9% (95% CI, -9.4%--0.2%) lower A1M levels among past users.LimitationsResults may not be generalizable to women.ConclusionsHIV-infected men had higher urine A1M levels compared with HIV-uninfected men. Among HIV-infected men, cumulative TDF exposure was associated with incrementally higher A1M levels, whereas time since TDF treatment discontinuation was associated with progressively lower A1M levels. Urine A1M appears to be a promising biomarker ... |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
qt9jp036bx; https://escholarship.org/uc/item/9jp036bxTest |
| الإتاحة: |
https://escholarship.org/uc/item/9jp036bxTest |
| حقوق: |
public |
| رقم الانضمام: |
edsbas.F6DCB61F |
| قاعدة البيانات: |
BASE |
