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المؤلفون: Assunta Sellitto, Valerio Gigantino, Malin Åkerfelt, Giorgio Giurato, Annamaria Salvati, Eugenio Morelli, Tuula A. Nyman, Domenico Memoli, Giovanni Nassa, Luciano Milanesi, Donatella Malanga, Elena Alexandrova, Sara Kangaspeska, Alessandro Weisz, Teresa Mirante, Matthias Nees, Francesca Rizzo, Roberta Tarallo
المصدر: Science Advances (2019). doi:10.1126/sciadv.aav5590
info:cnr-pdr/source/autori:Nassa G, Salvati A, Tarallo R, Gigantino V, Alexandrova E, Memoli D, Sellitto A, Rizzo F, Malanga D, Mirante T, Morelli E, Nees M, Åkerfelt M, Kangaspeska S, Nyman TA, Milanesi L, Giurato G, Weisz A./titolo:Inhibition of histone methyltransferase DOT1L silences ER? gene and blocks proliferation of antiestrogen-resistant breast cancer cells/doi:10.1126%2Fsciadv.aav5590/rivista:Science Advances/anno:2019/pagina_da:/pagina_a:/intervallo_pagine:/volume
Science Advancesمصطلحات موضوعية: Methyltransferase, Transcription, Genetic, Estrogen receptor, Mice, Breast cancer, 0302 clinical medicine, Estrogen Receptor Modulators, skin and connective tissue diseases, Research Articles, Cancer, 0303 health sciences, Multidisciplinary, SciAdv r-articles, breast cancer, epigenetics, targeted therapy, bioinformatics, targeted therapy, Chromatin, 3. Good health, Gene Expression Regulation, Neoplastic, 030220 oncology & carcinogenesis, Female, hormones, hormone substitutes, and hormone antagonists, Research Article, Protein Binding, Signal Transduction, Breast Neoplasms, Biology, ta3111, 03 medical and health sciences, Cell Line, Tumor, Animals, Humans, Gene silencing, Gene Silencing, Epigenetics, Cell Proliferation, 030304 developmental biology, epigenetics, endocrine therapy, Estrogen Receptor alpha, Cell Cycle Checkpoints, Histone-Lysine N-Methyltransferase, DOT1L, ta3122, Antiestrogen, Xenograft Model Antitumor Assays, Disease Models, Animal, Drug Resistance, Neoplasm, Cancer research, FOXA1
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12df41a9e947b7606ac2861f63f9f068Test
https://doi.org/10.1126/sciadv.aav5590Test -
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المصدر: Statistics in Biopharmaceutical Research. 8:217-228
مصطلحات موضوعية: 0301 basic medicine, Statistics and Probability, Biometrics, Computer science, Tumor spheroid, Pharmaceutical Science, Principal curves, ta3111, 01 natural sciences, Texture (geology), 010104 statistics & probability, 03 medical and health sciences, Computer vision, 0101 mathematics, Cluster analysis, Throughput (business), ta113, ta112, business.industry, ta1182, Pattern recognition, ta3122, Multicellular organism, 030104 developmental biology, Microscopic imaging, Artificial intelligence, business
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf245302516c24d656824227c26f5812Test
https://doi.org/10.1080/19466315.2016.1146162Test -
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المؤلفون: Jenny Joutsen, Fang Cheng, Mikael C. Puustinen, Johanna K. Björk, Lea Sistonen, Malin Åkerfelt, Matthias Nees
المصدر: Björk, J K, Åkerfelt, M, Joutsen, J, Puustinen, M C, Cheng, F, Sistonen, L & Nees, M 2016, ' Heat-shock factor 2 is a suppressor of prostate cancer invasion ', Oncogene, vol. 35, no. 14, pp. 1770-84 . https://doi.org/10.1038/onc.2015.241Test
Oncogeneمصطلحات موضوعية: Male, 0301 basic medicine, Cancer Research, Biology, medicine.disease_cause, ta3111, Metastasis, Mice, RHO signalling, 03 medical and health sciences, Prostate cancer, SDG 3 - Good Health and Well-being, Cell Line, Tumor, Biomarkers, Tumor, Genetics, medicine, Animals, Humans, metastasis, Neoplasm Invasiveness, Neoplasm Metastasis, HSF1, Cell adhesion, Molecular Biology, Heat-Shock Proteins, Actin, ta1184, ta1182, Prostatic Neoplasms, Cancer, Cell Differentiation, prostate cancer, medicine.disease, Actin cytoskeleton, ta3122, Xenograft Model Antitumor Assays, Cell biology, Gene Expression Regulation, Neoplastic, 030104 developmental biology, Tumor progression, Original Article, Neoplasm Grading, Carcinogenesis, Transcription Factors
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1086c344a0abcd5eeff393db512281fdTest
http://juuli.fi/Record/0006694915Test -
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المؤلفون: Hannu-Pekka Schukov, Matthias Nees, Janne Heikkilä, Malin Åkerfelt, Sean Robinson, Raija Sormunen, Neslihan Bayramoglu, Johannes Virtanen, Juho Kannala, Mika Kaakinen, Mervi Toriseva, Ville Härmä, Lauri Eklund
المساهمون: Turku Centre for Biotechnology, University of Turku-Åbo Academy University, University of Turku, Laboratoire de Biologie à Grande Échelle (BGE - UMR S1038), Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), VTT Technical Research Centre of Finland (VTT), Machine Vision Group (MVG), University of Oulu, Center for Machine Vision Research (CMV), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)
المصدر: Oncotarget
Oncotarget, Impact journals, 2015, 6 (30), ⟨10.18632/oncotarget.5046⟩
Oncotarget, 2015, 6 (30), ⟨10.18632/oncotarget.5046⟩
Åkerfelt, M, Bayramoglu, N, Robinson, S, Toriseva, M, Schukov, H-P, Härmä, V, Virtanen, J, Sormunen, R, Kaakinen, M, Kannala, J, Eklund, L, Heikkilä, J & Nees, M 2015, ' Automated tracking of tumor-stroma morphology in microtissues identifies functional targets within the tumor microenvironment for therapeutic intervention ', Oncotarget, vol. 6, no. 30, pp. 30035-30056 . https://doi.org/10.18632/oncotarget.5046Testمصطلحات موضوعية: Male, [SDV]Life Sciences [q-bio], focal adhesion kinase (FAK), Cell Culture Techniques, Cell Communication, Prostate cancer, 0302 clinical medicine, Cell Movement, Tumor Microenvironment, ComputingMilieux_MISCELLANEOUS, 0303 health sciences, Microscopy, Confocal, 3D co-culture, invasion, University hospital, 3. Good health, Oncology, Cell Tracking, Research centre, 030220 oncology & carcinogenesis, Collagen, Algorithms, Research Paper, Cancer associated fibroblast, ta3111, Models, Biological, Time-Lapse Imaging, Cell Line, 03 medical and health sciences, Microscopy, Electron, Transmission, SDG 3 - Good Health and Well-being, Cell Line, Tumor, medicine, Humans, Tumor growth, Tumor stroma, Protein Kinase Inhibitors, Cell Proliferation, 030304 developmental biology, ta113, Tumor histology, Tumor microenvironment, cancer associated fibroblast (CAF), business.industry, phenotypic screening, ta1182, Granulocyte-Macrophage Colony-Stimulating Factor, Prostatic Neoplasms, Fibroblasts, ta3122, medicine.disease, Coculture Techniques, Focal Adhesion Protein-Tyrosine Kinases, Cancer research, business
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c93326a6d15c89889a4ac7e1d2f45097Test
https://doi.org/10.18632/oncotarget.5046Test -
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المؤلفون: Mervi Toriseva, Jixi Zhang, Neeraj Prabhakar, Jessica M. Rosenholm, Malin Åkerfelt, Tuomas Näreoja, Matthias Nees, Diti Desai
المصدر: Pharmaceutics
Volume 10
Issue 4
Pharmaceutics, Vol 10, Iss 4, p 237 (2018)مصطلحات موضوعية: intracellular delivery, lcsh:RS1-441, Pharmaceutical Science, Nanoparticle, macromolecular substances, 02 engineering and technology, 010402 general chemistry, ta3111, 01 natural sciences, Article, live-cell imaging, lcsh:Pharmacy and materia medica, Live cell imaging, Organoid, Surface charge, mesoporous silica nanoparticles, Lipid bilayer, ta317, Chemistry, cargo hydrophilicity, Mesoporous silica, 021001 nanoscience & nanotechnology, cargo hydrophobicity, 0104 chemical sciences, Drug delivery, cancer cells, Biophysics, organotypic 3D culture, 0210 nano-technology, cell labeling, Intracellular
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e676c4f4fc25310fcd346141631dad80Test
http://juuli.fi/Record/0333749318Test -
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المؤلفون: Milena Doroszko, Xiangdong Li, Jukka Kero, Slawomir Wolczynski, Malin Åkerfelt, Nafis A. Rahman, Donata Ponikwicka-Tyszko, Matthias Nees, Ilpo Huhtaniemi, Marcin Chrusciel, Joanna Stelmaszewska, Marco Frentsch
المصدر: Scientific Reports
مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, endocrine system, Angiogenesis, Neovascularization, Physiologic, Biology, ta3111, Article, Umbilical vein, Neovascularization, 03 medical and health sciences, Pregnancy, Internal medicine, Human Umbilical Vein Endothelial Cells, medicine, Humans, ta318, Receptor, Cell Proliferation, Tube formation, Multidisciplinary, 030102 biochemistry & molecular biology, ta1182, ta3141, Transfection, ta3123, Cell biology, HEK293 Cells, 030104 developmental biology, Endocrinology, Gene Expression Regulation, Hormone receptor, embryonic structures, cardiovascular system, Receptors, FSH, Female, 500 Naturwissenschaften und Mathematik::570 Biowissenschaften, Biologie::572 Biochemie, Follicle Stimulating Hormone, medicine.symptom, Wound healing
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8224eb80ab47186a127f79bd96df446Test
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المؤلفون: Kirsi-Marja Oksman-Caldentey, Ville Härmä, Raisa Haavikko, Heiko Rischer, Matthias Nees, Hannu-Pekka Schukov, Johannes Virtanen, Vânia M. Moreira, Enkhee Purev, Ilmari Ahonen, Jari Yli-Kauhaluoma, Sami Alakurtti
المساهمون: Faculty of Pharmacy, Jari Yli-Kauhaluoma / Principal Investigator, Drug Discovery, Division of Pharmaceutical Chemistry and Technology, Pharmaceutical Design and Discovery group, Drug Research Program
المصدر: Härmä, V, Haavikko, R, Virtanen, J, Ahonen, I, Schukov, H-P, Alakurtti, S, Purev, E, Rischer, H, Yli-Kauhaluoma, J, Moreira, V M, Nees, M & Oksman-Caldentey, K-M 2015, ' Optimization of Invasion-Specific Effects of Betulin Derivatives on Prostate Cancer Cells through Lead Development ', PLoS ONE, vol. 10, no. 5, e0126111 . https://doi.org/10.1371/journal.pone.0126111Test
PLoS ONE, Vol 10, Iss 5, p e0126111 (2015)
PLoS ONEمصطلحات موضوعية: Male, EXPRESSION, MIGRATION, Science, Motility, Biology, Cell morphology, ta3111, 3RD-DIMENSION, RS, CULTURE, Prostate cancer, CYP17 INHIBITORS, SDG 3 - Good Health and Well-being, TUMOR SPHEROIDS, Cell Line, Tumor, LNCaP, medicine, Humans, PLASTICITY, Mitosis, Cell Proliferation, Multidisciplinary, Cell growth, ta1182, Epithelial Cells, medicine.disease, Actin cytoskeleton, Triterpenes, 3. Good health, Cell biology, Gene Expression Regulation, Neoplastic, MODEL, Prostatic Neoplasms, Castration-Resistant, Cell culture, 317 Pharmacy, DISCOVERY, ACID, Androgens, Medicine, Protein Kinases, Signal Transduction, Research Article
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc19703b1a804cbf4b9dc5840bc95e23Test
https://cris.vtt.fi/en/publications/63da1049-9218-45d4-bc9b-feed76123726Test -
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المؤلفون: Neslihan Bayramoglu, Janne Heikkilä, Malin Åkerfelt, Mika Kaakinen, Matthias Nees, Lauri Eklund, Juho Kannala
المصدر: ICIP
مصطلحات موضوعية: Pixel, business.industry, GLOH, ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION, Pattern recognition, Filter (signal processing), ta3111, Pipeline (software), Independent component analysis, Image (mathematics), Computer Science::Computer Vision and Pattern Recognition, Histogram, Statistics, Computer vision, Artificial intelligence, Representation (mathematics), business, Mathematics
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f036ab1cf0cff11a4978f6d2b375f20Test
http://juuli.fi/Record/0252566915Test -
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المؤلفون: Esa Kähkönen, Terhi Tallgren, Saeid Alinezhad, Peter J. Boström, Otto Ettala, Kari T. Syvänen, Markku Kallajoki, Pekka Taimen, Ileana Montoya Perez, Kim Pettersson, Hannu J. Aronen, Riina-Minna Väänänen, Matthias Nees, Ivan Jambor
المصدر: Urologic Oncology: Seminars and Original Investigations. 34:255.e15-255.e22
مصطلحات موضوعية: Male, 0301 basic medicine, PCA3, Oncology, medicine.medical_specialty, Oncogene Proteins, Fusion, Urology, Cell Cycle Proteins, ta3111, urologic and male genital diseases, 03 medical and health sciences, Prostate cancer, 0302 clinical medicine, Prostate, Internal medicine, Biopsy, medicine, Humans, Prospective Studies, RNA, Messenger, Prospective cohort study, Aged, Aged, 80 and over, ta3126, medicine.diagnostic_test, business.industry, Prostatic Neoplasms, Cancer, Middle Aged, Prostate-Specific Antigen, ta3122, medicine.disease, Magnetic Resonance Imaging, Prostate-specific antigen, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Neoplasm Grading, Carrier Proteins, business, Primary Gleason Pattern
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::799d7973653a3d180ba4e846ffcb75cbTest
https://doi.org/10.1016/j.urolonc.2015.12.014Test -
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المؤلفون: Olli-Pekka Kallioniemi, Antti Rannikko, Matthias Nees, Tiina Vesterinen, Anna Sankila, J P Mpindi, Pekka Kohonen, Ville Härmä, Mari Björkman, Johannes Virtanen, E Kaivanto, Mikael Lundin, Juha Rantala, Päivi Östling, Tuomas Mirtti
المصدر: Björkman, M, Östling, P, Härmä, V, Virtanen, J, Mpindi, J, Rantala, J K, Mirtti, T, Vesterinen, T, Lundin, M, Sankila, A, Rannikko, A, Kaivanto, E, Kohonen, P, Kallioniemi, O & Nees, M 2011, ' Systematic knockdown of epigenetic enzymes identifies a novel histone demethylase PHF8 overexpressed in prostate cancer with an impact on cell proliferation, migration and invasion ', Oncogene, vol. 31, no. 29, pp. 3444-3456 . https://doi.org/10.1038/onc.2011.512Test
مصطلحات موضوعية: Adult, Male, Cancer Research, Jumonji Domain-Containing Histone Demethylases, Epigenetic regulation of neurogenesis, Biology, ta3111, Histone Deacetylases, Epigenesis, Genetic, 03 medical and health sciences, 0302 clinical medicine, SDG 3 - Good Health and Well-being, Cell Movement, Histone methylation, Genetics, Humans, Neoplasm Invasiveness, Epigenetics, Cancer epigenetics, Molecular Biology, 030304 developmental biology, Epigenomics, Aged, Cell Proliferation, Regulation of gene expression, Aged, 80 and over, Histone Demethylases, 0303 health sciences, Prostatic Neoplasms, Epigenome, Middle Aged, Molecular biology, 3. Good health, Gene Expression Regulation, Neoplastic, Receptors, Androgen, 030220 oncology & carcinogenesis, Gene Knockdown Techniques, Cancer research, biology.protein, Demethylase, Transcription Factors
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d636b391b1408fa7f1a31ed7e81ccce8Test
https://cris.vtt.fi/en/publications/558a95f2-a770-4a25-a5af-6e35304c31f1Test
