دورية أكاديمية
Involvement and prognosis value of CD8+ T cells in giant cell arteritis
| العنوان: | Involvement and prognosis value of CD8+ T cells in giant cell arteritis |
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| المؤلفون: | Samson, Maxime, Ly, Kim Heang, Tournier, Benjamin, Janikashvili, Nona, Trad, Malika, Ciudad, Marion, Gautheron, Alexandrine, Devilliers, Hervé, Quipourt, Valérie, Maurier, François, Meaux-Ruault, Nadine, Magy-Bertrand, Nadine, Manckoundia, Patrick, Ornetti, Paul, Maillefert, Jean-Francis, Besancenot, François, Ferrand, Christophe, Mesturoux, Laura, Labrousse, François, Fauchais, Anne-Laure, Saas, Philippe, Martin, Laurent, Audia, Sylvain, Bonnotte, Bernard |
| المساهمون: | Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) (RIGHT), Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang Bourgogne-Franche-Comté (EFS BFC)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté COMUE (UBFC)-Université Bourgogne Franche-Comté COMUE (UBFC), Service de médecine interne et immunologie clinique (SOC 1) CHU de Dijon, Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Service de Médecine interne A et polyclinique médicale CHU Limoges, CHU Limoges, Lipides - Nutrition - Cancer (U866) (LNC), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon (ENSBANA), Service de médecine interne et maladies systémiques (SOC 2) CHU de Dijon, Service de médecine gériatrique (CHU de Dijon - Centre gériatrique de Champmaillot - EHPAD), Service de médecine interne, Hôpital Sainte-Blandine-Centre hospitalier régional Metz-Thionville (CHR Metz-Thionville), Service de médecine interne (Med Int - BESANCON), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Cognition, Action, et Plasticité Sensorimotrice Dijon - U1093 (CAPS), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Rhumatologie (CHU de Dijon), Service d'Anatomie Pathologique CHU Limoges, Service de Pathologie CHU de Dijon |
| المصدر: | ISSN: 0896-8411. |
| بيانات النشر: | HAL CCSD Elsevier |
| سنة النشر: | 2016 |
| المجموعة: | Université de Franche-Comté (UFC): HAL |
| مصطلحات موضوعية: | Giant cell arteritis, Cytotoxic T cells, Autoimmune-diseases, Glucocorticoids, Vasculitis, T-lymphocyte, Takayasus-arteritis, Large-Vessel vasculitis, Cd8+ lymphocyte subset, Polymyalgia-rheumatica, Temporal arteritis, Peripheral-blood, Cxcr3, Pathogenesis, Activation, [SDV.IMM]Life Sciences [q-bio]/Immunology |
| الوصف: | IF 7.760 ; International audience ; CD8(+) T cells participate in the pathogenesis of some vasculitides. However, little is known about their role in Giant Cell Arteritis (GCA). This study was conducted to investigate CD8(+) T cell involvement in the pathogenesis of GCA.Analyses were performed at diagnosis and after 3 months of glucocorticoid treatment in 34 GCA patients and 26 age-matched healthy volunteers . Percentages of CD8(+) T-cell subsets, spectratype analysis of the TCR v beta families of CD8(+) T cells, levels of cytokines and chemokines and immunohistochemistry of temporal artery biopsies (TAB) were assessed.Among total CD8+ T cells, percentages of circulating cytotoxic CD8 T lymphocytes (CTL, CD3(+)CD8(+)perforin(+)granzymeB(+)), Tc17 (CD3(+)CD8(+)IL-17(+)), CD63(+)CD8(+) T cells and levels of soluble granzymes A and B were higher in patients than in controls, whereas the percentage of Tc1 cells (CD3(+)CD8(+)IFN-gamma(+)) was similar. Moreover, CD8+ T cells displayed a restricted TCR repertoire in GCA patients. Percentages of circulating CTL, Tc17 and soluble levels of granzymes A and B decreased after treatment. CXCR3 expression on CD8(+) T cells and its serum ligands (CXCL9, -10, -11) were higher in patients. Analyses of TAB revealed high expression of CXCL9 and -10 associated with infiltration by CXCR3(+)CD8(+) T cells expressing granzyme B and TiA1. The intensity of the CD8 T-cell infiltrate in TAB was predictive of the severity of the disease.This study demonstrates the implication and the prognostic value of CD8(+) T-cells in GCA and suggests that CD8(+) T-cells are recruited within the vascular wall through an interaction between CXCR3 and its ligands. (C) 2016 Elsevier Ltd. All rights reserved. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/27236507; hal-01431809; https://u-bourgogne.hal.science/hal-01431809Test; PUBMED: 27236507 |
| DOI: | 10.1016/j.jaut.2016.05.008 |
| الإتاحة: | https://doi.org/10.1016/j.jaut.2016.05.008Test https://u-bourgogne.hal.science/hal-01431809Test |
| رقم الانضمام: | edsbas.7B5064D0 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.jaut.2016.05.008 |
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