التفاصيل البيبلوغرافية
| العنوان: |
At Embryo Implantation Site IL-35 Secreted by Trophoblast, Polarizing T Cells towards IL-35+ IL-10+ IL-4+ Th2-Type Cells, Could Favour Fetal Allograft Tolerance and Pregnancy Success. |
| المؤلفون: |
Lombardelli, Letizia, Logiodice, Federica, Kullolli, Ornela, Haller, Herman, Agostinis, Chiara, Bulla, Roberta, Rukavina, Daniel, Piccinni, Marie-Pierre |
| المصدر: |
International Journal of Molecular Sciences; May2022, Vol. 23 Issue 9, p4926-4926, 23p |
| مصطلحات موضوعية: |
TROPHOBLAST, EMBRYO implantation, DECIDUA, T cells, CELL physiology, PREGNANCY, HOMOGRAFTS |
| مستخلص: |
We investigated the role of rhIL-35, at low concentrations compatible with those produced by human trophoblast cells (less than 1 ng/mL), on human T helper (Th) cell functions and the presence of decidual IL-35-producing Th cells in human pregnancy. We found that human trophoblast cells produced IL-35 but not IL-4 or IL-10. RhIL-35, at concentrations produced by human trophoblasts, polarized T cells towards IL-35+, IL-10+, IL-4+ Th2-type cells and to Foxp3+ EBI3+ p35+ T reg cells producing IL-35 but not IL-10 and IL-4. Moreover, rhIL-35 at low concentrations did not suppress the proliferation of Th cells but stimulated IL-4 and IL-10 production by established Th clones. In particular, Th1-type clones acquired the capacity to produce IL-4. In addition, purified human trophoblast cell supernatants containing IL-35 upregulated IL-4 and IL-10 production by Th clones. Finally, IL-35+, IL-10+, IL-4+ Th2-type cells, which were found to be induced by low concentrations of IL-35 compatible with those produced by human trophoblasts, are exclusively present in the decidua of a successful pregnancy and at the embryo implantation site, suggesting their stringent dependence on trophoblast cells. Thus, the proximity of Th cells to IL-35-producing trophoblasts could be the determining factor for the differentiation of IL-35+, IL-10+, IL-4+ Th2-type cells that are crucial for human pregnancy success. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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