التفاصيل البيبلوغرافية
| العنوان: |
Epigenetic Regulation of Survivin by Bmi1 Is Cell Type Specific During Corticogenesis and in Gliomas. |
| المؤلفون: |
Acquati, Serena, Greco, Azzura, Licastro, Danilo, Bhagat, Heeta, Ceric, Dario, Rossini, Zefferino, Grieve, Joan, Shaked-Rabi, Maya, Henriquez, Nick V., Brandner, Sebastian, Stupka, Elia, Marino, Silvia |
| المصدر: |
Stem Cells; Jan2013, Vol. 31 Issue 1, p190-202, 13p |
| مصطلحات موضوعية: |
GLIOMA treatment, GENETIC regulation, SURVIVIN (Protein), NEURAL stem cells, POLYCOMB group proteins, EMBRYONIC stem cells, GENE expression, OXIDATIVE stress, DNA damage |
| مستخلص: |
Polycomb group proteins are essential regulators of stem cell function during embryonic development and in adult tissue homeostasis. Bmi1, a key component of the Polycomb Repressive Complex 1, is highly expressed in undifferentiated neural stem cells (NSC) as well as in several human cancers including high-grade gliomas-highly aggressive brain tumors. Using a conditional gene activation approach in mice, we show that overexpression of Bmi1 induces repressive epigenetic regulation of the promoter of Survivin, a well-characterized antiapoptotic protein. This phenomenon is cell type-specific and it leads to apoptotic death of progenitor cells exclusively upon commitment toward a neuronal fate. Moreover, we show that this is triggered by increased oxidative stress-induced DNA damage. In contrast, undifferentiated NSC as well as glioma-initiating cells display an open chromatin configuration at the Survivin promoter and do not undergo apoptotic death. These findings raise the possibility that normal and neoplastic stem cells depend on the same mechanism for surviving the hyperproliferative state induced by increased Bmi1 expression. S TEM C ells 2013;31:190-202 [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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