يعرض 1 - 4 نتائج من 4 نتيجة بحث عن '"Heidemarie Kletzl"', وقت الاستعلام: 1.13s تنقيح النتائج
  1. 1
    Addressing Today's Absorption, Distribution, Metabolism, and Excretion (ADME) Challenges in the Translation of In Vitro ADME Characteristics to Humans: A Case Study of the

    المؤلفون: Stephen, Fowler, Andreas, Brink, Yumi, Cleary, Andreas, Günther, Katja, Heinig, Christophe, Husser, Heidemarie, Kletzl, Nicole, Kratochwil, Lutz, Mueller, Mark, Savage, Cordula, Stillhart, Dietrich, Tuerck, Mohammed, Ullah, Kenichi, Umehara, Agnès, Poirier

    المصدر: Drug metabolism and disposition: the biological fate of chemicals. 50(1)

    مصطلحات موضوعية: Survival of Motor Neuron 2 Protein, Pyrimidines, Pharmaceutical Preparations, RNA Splicing, Animals, Humans, Tissue Distribution, RNA, Messenger, In Vitro Techniques, Azo Compounds

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::4530dce338c940f32f354504129eb183Test
    https://pubmed.ncbi.nlm.nih.gov/34620695Test


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  2. 2
    Discovery of Risdiplam, a Selective Survival of Motor Neuron-2 ( SMN2) Gene Splicing Modifier for the Treatment of Spinal Muscular Atrophy (SMA)

    المؤلفون: Agnès Poirier, Lutz Mueller, Heidemarie Kletzl, Chien-Ping Ko, Stefan Kustermann, Omar Khwaja, Hasane Ratni, Zhihua Feng, Johan Bylund, Bjoern Jacobsen, Michael Reutlinger, Melanie Guérard, Emmanuel Pinard, Sergey Paushkin, John D. Baird, Nikolai Naryshkin, Stefanie Bendels, Anne Marquet, Nora Denk, Xin Zhao, Philippe Jablonski, Martin Ebeling, Luke Green, Friedrich Metzger, Andreas Zeller, Barbara Mueller, Karen S. Chen, Marla Weetall

    المصدر: Journal of medicinal chemistry. 61(15)

    مصطلحات موضوعية: 0301 basic medicine, Drug discovery, Chemistry, Gene splicing, RNA Splicing, Survival of motor neuron, Spinal muscular atrophy, medicine.disease, Bioinformatics, SMA, Clinical trial, Muscular Atrophy, Spinal, Survival of Motor Neuron 2 Protein, 03 medical and health sciences, 030104 developmental biology, Pyrimidines, RNA splicing, Drug Discovery, medicine, Molecular Medicine, Animals, Humans, Dosing, Safety, Azo Compounds

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d9e69d504357bfed8927794453d1858Test
    https://pubmed.ncbi.nlm.nih.gov/30044619Test


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  3. 3
    The oral splicing modifier RG7800 increases full length survival of motor neuron 2 mRNA and survival of motor neuron protein: Results from trials in healthy adults and patients with spinal muscular atrophy

    المؤلفون: Jules A. A. C. Heuberger, Eugenio Mercuri, Katja Heinig, Russell Kinch, Andreas Günther, Irene Gerlach, Wakana Tang, Teodorica L. Bugawan, Omar Khwaja, Geert Jan Groeneveld, W. Birkhoff, Heidemarie Kletzl, Claire L Wood, Hanns Lochmüller, Sebastian Dziadek, Dirk Fischer, Christian Czech, Anne Marquet

    المصدر: Neuromuscular disorders : NMD. 29(1)

    مصطلحات موضوعية: 0301 basic medicine, Adult, Male, Adolescent, animal diseases, Administration, Oral, SMN1, Bioinformatics, spinal muscular atrophy, Muscular Atrophy, Spinal, 03 medical and health sciences, Exon, Young Adult, Settore MED/39 - NEUROPSICHIATRIA INFANTILE, 0302 clinical medicine, Double-Blind Method, medicine, Humans, RNA, Messenger, Child, Genetics (clinical), business.industry, Alternative splicing, Infant, Survival of motor neuron, Spinal muscular atrophy, Motor neuron, Middle Aged, medicine.disease, SMA, Muscle atrophy, nervous system diseases, Survival of Motor Neuron 2 Protein, Alternative Splicing, 030104 developmental biology, medicine.anatomical_structure, Pyrimidines, nervous system, Neurology, Neuromuscular Agents, Child, Preschool, Pyrazines, Pediatrics, Perinatology and Child Health, Female, Neurology (clinical), medicine.symptom, business, 030217 neurology & neurosurgery

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cd3af212d2a80d491e04b1614b29a09Test
    https://pubmed.ncbi.nlm.nih.gov/30553700Test


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  4. 4
    A phase 1 healthy male volunteer single escalating dose study of the pharmacokinetics and pharmacodynamics of risdiplam (RG7916, RO7034067), a SMN2 splicing modifier

    المؤلفون: Yumi Cleary, Katja Heinig, Lutz Müller, Hasane Ratni, Omar Khwaja, Nicolas Frances, Paul Jordan, Agnès Poirier, Birgit Jaber, Tobias Bergauer, Heidemarie Kletzl, Nada Al Kotbi, Stefan Sturm, Anne Marquet, Andreas Günther, Christian Czech, Nikhat Parkar

    المصدر: British journal of clinical pharmacology. 85(1)

    مصطلحات موضوعية: Adult, Male, Adolescent, CYP3A, Itraconazole, RNA Splicing, Administration, Oral, Pharmacology, Placebo, 030226 pharmacology & pharmacy, Muscular Atrophy, Spinal, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Pharmacokinetics, Double-Blind Method, Medicine, Humans, Pharmacology (medical), Drug Interactions, 030212 general & internal medicine, RNA, Messenger, Volunteer, business.industry, Original Articles, Middle Aged, Confidence interval, Healthy Volunteers, Survival of Motor Neuron 2 Protein, Pyrimidines, Tolerability, Neuromuscular Agents, Pharmacodynamics, Area Under Curve, Cytochrome P-450 CYP3A Inhibitors, business, Azo Compounds, medicine.drug

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39a179691a66077906bc034e6725650dTest
    https://pubmed.ncbi.nlm.nih.gov/30302786Test


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