المؤلفون: Homare Nakamura, Hiroo Kobayashi, Tadashi Kudo, Yoshio Taguchi

المصدر: NMC Case Report Journal

مصطلحات موضوعية: Neurofibromatosis type I, 030222 orthopedics, Weakness, medicine.medical_specialty, business.industry, Dural ectasia, Case Report, dystrophic type, minor trauma, medicine.disease, Spinal cord, spinal cord injury, Surgery, Lesion, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, Thoracic vertebrae, medicine, medicine.symptom, Traumatic dislocation, business, Spinal cord injury, 030217 neurology & neurosurgery

الوصف: The authors reported a rare case of young women with neurofibromatosis type I (NF-I) who were successfully treated from the traumatic dislocation of a thoracic vertebra caused by a simple fall, and the relevant literature was reviewed. Due to various spinal dystrophic changes, the conventional posterior spinal fusion surgery was modified for the treatment. Spinal deformity is a common feature of NF-1, and a dystrophic lesion, like dural ectasia, provokes weakness in spinal structural. Unexpectedly, only seven similar cases were found. The review suggested that it is mandatory to thoroughly examine the spine in patients with NF-1, and that a good outcome can be expected even for patients with NF-1 in severe neurological condition after acute spinal cord injuries.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::306747b245dbd415a47f5e11fa162466Test
https://doi.org/10.2176/nmccrj.cr.2018-0051Test

المؤلفون: Yoshio, Taguchi, Masahito, Ebina, Seishu, Hashimoto, Takashi, Ogura, Arata, Azuma, Hiroyuki, Taniguchi, Yasuhiro, Kondoh, Moritaka, Suga, Hiroki, Takahashi, Koichiro, Nakata, Yukihiko, Sugiyama, Shoji, Kudoh, Toshihiro, Nukiwa, M, Kawabata

المصدر: Respiratory Investigation. 53:279-287

مصطلحات موضوعية: Adult, Male, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Vital capacity, Pyridones, Vital Capacity, Population, Severity of Illness Index, Gastroenterology, Young Adult, Idiopathic pulmonary fibrosis, FEV1/FVC ratio, Oxygen Consumption, DLCO, Internal medicine, medicine, Humans, Progression-free survival, education, Aged, Retrospective Studies, education.field_of_study, business.industry, Anti-Inflammatory Agents, Non-Steroidal, Therapeutic effect, Pirfenidone, Middle Aged, medicine.disease, Idiopathic Pulmonary Fibrosis, Surgery, Survival Rate, Treatment Outcome, Clinical Trials, Phase III as Topic, Female, business, medicine.drug

الوصف: Background A phase III clinical trial of pirfenidone in patients with idiopathic pulmonary fibrosis (IPF) in Japan has revealed that pirfenidone attenuated the decline in vital capacity (VC) and improved progression-free survival (PFS). We conducted an extended analysis of the pirfenidone trial to investigate its efficacy with respect to IPF severity in the trial population. Methods Patients in the phase III trial were stratified by baseline pulmonary functions including %VC predicted, %diffusion capacity for carbon monoxide predicted, and oxygen saturation by pulse oximetry on exertion and were categorized into mild, moderate, and severe groups of functional impairment. The efficacy of pirfenidone for VC and PFS over 52 weeks was compared among the three sub-populations. Results Of 264 patients, 102 (39%), 90 (34%), and 72 patients (27%) were classified as having mild, moderate, and severe grades of functional impairment, respectively. This classification was associated with arterial oxygen partial pressure at rest and degree of dyspnea at baseline. While pirfenidone attenuated VC decline at all grades of severity, covariance analysis revealed pirfenidone to have better efficacy in the sub-population with mild-grade IPF. Mixed model repeated measures analysis confirmed that pirfenidone markedly attenuated VC decline in patients with mild-grade IPF compared to its effects in patients with moderate or severe IPF. Pirfenidone also improved PFS markedly in patients with mild-grade IPF. Conclusion This extended analysis suggested that pirfenidone exerted better therapeutic effects in patients with milder IPF. Further analysis with a larger population is needed to confirm these results.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8813f4fb28a46786c323a4f3a35d4455Test
https://doi.org/10.1016/j.resinv.2015.06.002Test

المؤلفون: Shoji Kudoh, Toshihiro Nukiwa, Hiroki Takahashi, Koichiro Nakata, Masahito Ebina, Hiroyuki Taniguchi, Takashi Ogura, Arata Azuma, Yasuhiro Kondoh, Yukihiko Sugiyama, Yoshio Taguchi, Moritaka Suga

المصدر: Respiratory Investigation. 53:271-278

مصطلحات موضوعية: Adult, Male, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Exacerbation, Pyridones, Vital Capacity, Idiopathic pulmonary fibrosis, Oxygen Consumption, Risk Factors, Internal medicine, Humans, Medicine, Risk factor, Aged, Proportional Hazards Models, Univariate analysis, business.industry, Proportional hazards model, Anti-Inflammatory Agents, Non-Steroidal, Hazard ratio, Pirfenidone, Middle Aged, respiratory system, medicine.disease, Idiopathic Pulmonary Fibrosis, respiratory tract diseases, Surgery, Pulmonary Alveoli, Clinical Trials, Phase III as Topic, Acute Disease, Multivariate Analysis, Disease Progression, Population study, Female, business, medicine.drug

الوصف: Background Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is a lifethreatening event and one of the important endpoints in clinical trials involving IPF. Despite this, there has been little evaluation of the potential risk factors for AE-IPF in clinical trials. We evaluated the risk factors for AE-IPF in a phase III clinical trial of pirfenidone in Japanese IPF patients. Methods The study population comprised 267 patients. The effects of various baseline characteristics as possible risk factors for AE-IPF during the study, as well as those of a ≥10% decline in percent vital capacity (%VC) within 6 months, were evaluated using Cox׳s proportional hazard model. The ≥10% decline in %VC was calculated in two ways: (1) an absolute decline (e.g. from 60% predicted to 50%); and (2) a relative decline (e.g. from 60% predicted to 54%). Results Over 52 weeks, 14 patients experienced AE-IPF. Univariate analysis using Cox׳s proportional hazards model showed that both relative and absolute ≥10% decline in %VC within 6 months were significant risk factors for AE-IPF. Stepwise multivariate analysis demonstrated that absolute or relative decline in both %VC and alveolar to arterial oxygen pressure difference (AaDO 2 ) were significant risk factors for AE. The model using absolute decline [Hazard Ration (HR)=7.405, p =0.0007] and baseline AaDO 2 (HR=1.063, p =0.0266) had a better fit than the model using relative decline and baseline AaDO 2 . Conclusions Rapid %VC decline (≥10% within 6 months), and high baseline AaDO 2 , may be risk factors for AE-IPF.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eec665536b154904de1bc5af1425a3e3Test
https://doi.org/10.1016/j.resinv.2015.04.005Test

المؤلفون: Hidemichi Ito, Daisuke Wakui, Homare Nakamura, Yoshio Taguchi, Atsushi Kobayashi, Hiroyuki Morishima, Kosuke Oshima, Takashi Matsumori, Tomoaki Terada, Yohtaro Sakakibara

المصدر: Journal of Neuroendovascular Therapy. 7:345-350

مصطلحات موضوعية: medicine.medical_specialty, business.industry, Direct puncture, Carotid-Cavernous Sinus Fistula, Medicine, Neurology (clinical), Radiology, Cardiology and Cardiovascular Medicine, business, Superior ophthalmic vein, Surgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::4e859bcf9531d829045a06f9137a5f7eTest
https://doi.org/10.5797/jnet.7.345Test

المؤلفون: Toru Shindo, Kohei Ikezoe, Kiminobu Tanizawa, Yoshio Taguchi, Seishu Hashimoto, Eisaku Tanaka, Yoichiro Kobashi, Satoshi Noma

المصدر: General Thoracic and Cardiovascular Surgery. 60:595-598

مصطلحات موضوعية: Male, Mesothelioma, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Pleural effusion, Pleural Neoplasms, medicine.medical_treatment, Iatrogenic Disease, Fatal Outcome, Surgical oncology, parasitic diseases, medicine, Humans, Aged, Pleural mesothelioma, business.industry, Pneumothorax, food and beverages, General Medicine, Pleural Diseases, respiratory system, Pleural cavity, Thymectomy, medicine.disease, Pleural Effusion, Malignant, respiratory tract diseases, Surgery, Cardiac surgery, Transplantation, Treatment Outcome, medicine.anatomical_structure, Cardiothoracic surgery, Disease Progression, Tomography, X-Ray Computed, Cardiology and Cardiovascular Medicine, business

الوصف: Buffalo chest refers to the pleuro-pleural communication that results in a single pleural cavity. Iatrogenic buffalo chest can occur following heart or heart-lung transplantation and other major thoracic surgeries. We present the case of malignant pleural mesothelioma in which iatrogenic buffalo chest after extended thymectomy caused bilateral pneumothoraces and contralateral dissemination of the disease. The free communication between bilateral pleural cavities had facilitated the rapid progression of tumor and the consequent bilateral malignant pleural effusions had made the management of disease much more difficult, leading to the early fatal outcome. To our knowledge, this is the first case of buffalo chest that was associated with bilateral malignant pleural effusions.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9db9055ed90b3fe41c6fb18e4b2790f4Test
https://doi.org/10.1007/s11748-012-0053-zTest

المؤلفون: Takashi Matsumori, Yoshio Taguchi, Yohtaro Sakakibara, Hidetaka Onodera, Homare Nakamura, Hirofumi Nakayama

المصدر: Surgery for Cerebral Stroke. 38:119-123

مصطلحات موضوعية: medicine.medical_specialty, Subarachnoid hemorrhage, business.industry, medicine.medical_treatment, Vasospasm, Clipping (medicine), Anatomy, medicine.disease, Temporal lobe, Surgery, Anterior communicating artery, Hematoma, medicine.artery, cardiovascular system, medicine, cardiovascular diseases, business, Craniotomy, Limen insulae

الوصف: We report a case of sylvian hematoma enlarging 3 days after neck clipping for a ruptured anterior communicating artery aneurysm, in the contralateral sylvian fissure to the operative approach. This 65-year-old man was admitted with sudden loss of consciousness by ambulance. Angiography revealed a saccular aneurysm at the anterior communicating artery complex, measuring 2.3×2.4 mm and pointing inferiorly. The aneurysmal neck was successfully clipped by using the right pterional approach. To minimize predictable vasospasm, the hematoma in the left sylvian stem was removed. Postoperative CT scan showed a considerable decrease in hematoma in the basal cistern, but a slight decrease in the vertical portion of the left sylvian fissure. The patient’s consciousness gradually recovered, but deteriorated again 3 days after the operation. CT scan showed a large high-density area in the sylvian fissure suggesting unexpected enlargement of sylvian hematoma. A left fronto-temporal craniotomy was performed. When the subpial hematoma around the sylvial fissure was removed, a large amount of bloody cerebrospinal fluid (CSF) flowed out. The cavity containing bloody fluid was located in the temporal lobe. Postoperative course was uneventful. He recovered well, but moderate sensory aphasia remained. Sylvian hematoma is rarely associated with ruptured anterior communicating artery aneurysms. Furthermore, there has been no report describing delayed onset sylvian hematoma as far as we are aware. The following mechanism was considered to explain this very rare condition. Removal of subarachnoid hematoma in the left sylvian fissure made a recovery of CSF flow up to the limen insulae, but CSF appeared to be blocked from entering the distal sylvian fissure by the thick subpial sylvian hematoma. Instead of normal CSF flow route, CSF may enter into the weakened subpial space to allow accumulation of bloody CSF in the temporal lobe. Subpial hematoma may act as a one-way valve.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::0806c73f3eafa04363fbc54e6065c9faTest
https://doi.org/10.2335/scs.38.119Test

المؤلفون: Daisuke Wakui, Jun Hiramoto, Yohtaro Sakakibara, Hiroshi Yoshida, Kouji Sakai, Hidetaka Onodera, Hidemichi Ito, Yoshio Taguchi

المصدر: Japanese Journal of Neurosurgery. 18:56-61

مصطلحات موضوعية: Pediatrics, medicine.medical_specialty, Fetus, Thesaurus (information retrieval), business.industry, medicine, Surgery, Neurology (clinical), medicine.disease, business, Thrombocytopenic purpura, Hydrocephalus

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::cdf06fafbdffb9ad2c2af5c94662eec2Test
https://doi.org/10.7887/jcns.18.56_1Test

المؤلفون: Yoshio Taguchi, Shu Endo, Takayasu Miyo, Yohtaro Sakakibara, Ryuta Suzuki, Tsukasa Fujimoto, Ryoichi Nakamura, Matsutaira Tsuyumu, Tatsuo Hayashi, Takashi Sakurai

المصدر: Surgery for Cerebral Stroke. 34:284-288

مصطلحات موضوعية: medicine.medical_specialty, Subarachnoid hemorrhage, business.industry, Hydrochloride, Glasgow Outcome Scale, Significant difference, Fasudil, medicine.disease, nervous system diseases, Surgery, Clinical study, chemistry.chemical_compound, chemistry, Anesthesia, Medicine, cardiovascular diseases, Symptomatic vasospasm, business

الوصف: Symptomatic vasospasm (SVS) can occur after subarachnoid hemorrhage (SAH) and has been considered as a factor associated with negative prognosis in SAH. However, no standard method for preventing SVS is currently available. Various preventive methods have thus been developed and conducted in each institution. To obtain a standardized preventive method for SVS after SAH, the present multi-institutional cooperative clinical study of fasudil hydrochloride was conducted in 5 institutions in Kanagawa Prefecture. Subjects comprised 112 SAH patients Frequency of AVS at 1 week after onset of SAH was 56% in all subjects, with 81% for Oz, 55% for Fa and 41% for Ni. A significant difference was observed between Oz and the other treatment groups. Frequency of SVS for all subjects was 22%, with 23% for Fa, 13% for Ni and 35% for Oz. A significant difference was noted between Ni and Oz groups. In the evaluation of Glasgow outcome scale (GOS) after 3 months, good recovery (GR) was achieved by 64% of all subjects, with 70% for Fa, 68% for Ni and 48% for Oz. A significant difference was identified between Fa and Oz groups. Fasudil hydrochloride is recommended for use as a standard therapeutic drug in SAH treatment.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::cab3176570ba0ec5377e8bbafdb0c2fcTest
https://doi.org/10.2335/scs.34.284Test

المؤلفون: Yoshio Taguchi, Michiko Ide, Kousuke Oshima, Kazuyoshi Uchida, Yohtaro Sakakibara, Toshiaki Chiba

المصدر: Nihon Kyukyu Igakukai Zasshi. 16:13-17

مصطلحات موضوعية: medicine.medical_specialty, business.industry, medicine.artery, Cavernous sinus, Medicine, Radiology, Internal carotid artery, business, Surgery

الوصف: 症例は38歳の男性。鼻出血にて当院救命センターに搬送された。傘で刺されて大量の鼻出血が持続していた。傘の先端は,左の鼻孔より挿入されたようであった。左の全眼筋麻痺と循環血液量減少性ショックであった。救急蘇生をすると突然,大量の拍動性の鼻出血をきたした。CT画像では,硬膜内に異常はみられなかったが,蝶形骨洞壁の左後外側の一部が欠損し,骨片が蝶形骨洞壁に接する左内頸動脈管内に突出していた。脳血管撮影では左内頸動脈は内頸動脈海綿静脈洞瘻のような不完全閉塞であり,左内頸動脈のcavernous portion遠位部の血流は認めなかった。左半球の血流は前交通動脈が十分発達しており保たれているようにみえた。左内頸動脈のトラッピングを後交通動脈の近位部で内頸動脈分岐部の遠位部で行い,鼻出血は完全に停止した。経過良好で受傷6か月後,以前の生活に戻った。このとき眼球異常も完全消失した。本症例は,救急診療において再鼻出血を伴う内頸動脈損傷の治療は注目すべきと思われ,内頸動脈損傷の治療について考察する。

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::1285853de803965415bee703471ad013Test
https://doi.org/10.3893/jjaam.16.13Test

المؤلفون: Masaaki Okada, Yohtaro Sakakibara, Yoshio Taguchi, Akiko Hoshi, Kazuyoshi Uchida

المصدر: Japanese Journal of Neurosurgery. 13:578-582

مصطلحات موضوعية: Thesaurus (information retrieval), Severe head injury, business.industry, Medicine, Surgery, Neurology (clinical), Anatomy, business, Posterior fossa arachnoid cyst

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::6053abd4da9149018b8ce7f111ff05a3Test
https://doi.org/10.7887/jcns.13.578Test